公开(公告)号：US20240165227A1

公开(公告)日：2024-05-23

申请号：US18499540

申请日：2023-11-01

申请人： Gilead Sciences, Inc.

发明人： Tianling Chen ,  Renu Jain ,  Michelle R. Kuhne ,  Dorothée Saddier Axe ,  Brian M. Weist

IPC分类号： A61K39/395 ,  A61K31/282 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/513 ,  A61K31/519 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7068 ,  A61K33/243 ,  A61K39/00 ,  A61P35/00

CPC分类号： A61K39/3955 ,  A61K31/282 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/513 ,  A61K31/519 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7068 ,  A61K33/243 ,  A61P35/00 ,  A61K2039/505

摘要： The present disclosure relates to methods of treating cancer in a subject by administrating an effective amount of an anti-CCR8 antibody, a chemotherapeutic agent (e.g., cisplatin, gemcitabine, docetaxel), and a PD1 inhibitor or PD-L1 inhibitor to the subject. In some embodiments, the chemotherapeutic agent is administered at a lower dose than in a standard of care chemotherapeutic regimen that does not comprise an anti-CCR8 antibody.

公开(公告)号：US20230295111A1

公开(公告)日：2023-09-21

申请号：US18297316

申请日：2023-04-07

申请人： Gilead Sciences, Inc.

发明人： Gayatri Balan ,  Peter A. Blomgren ,  Chen Chen ,  Julian A. Codelli ,  Zhimin Du ,  Musong Kim ,  Dorothée Saddier Axe ,  Gregg M. Schwarzwalder ,  Rhiannon Thomas-Tran ,  Michael T. Tudesco ,  Chandrasekar Venkataramani ,  William J. Watkins ,  Brian M. Weist ,  Suet C. Yeung ,  Helen Yu

IPC分类号： C07D401/04

CPC分类号： C07D401/04 ,  C07B2200/05

摘要： The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zinc Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2 and/or IKZF4, including cancer.

公开(公告)号：US20230373950A1

公开(公告)日：2023-11-23

申请号：US18184335

申请日：2023-03-15

申请人： Gilead Sciences, Inc.

发明人： Gayatri Balan ,  Peter A. Blomgren ,  Chen Chen ,  Julian A. Codelli ,  Zhimin Du ,  Musong Kim ,  Dorothée Saddier Axe ,  Gregg M. Schwarzwalder ,  Rhiannon Thomas-Tran ,  Michael T. Tudesco ,  Chandrasekar Venkataramani ,  William J. Watkins ,  Brian M. Weist ,  Suet C. Yeung ,  Helen Yu

IPC分类号： C07D401/04

CPC分类号： C07D401/04 ,  C07B2200/05

摘要： The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zinc Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2 and/or IKZF4, including cancer.

公开(公告)号：US11897862B2

公开(公告)日：2024-02-13

申请号：US18297316

申请日：2023-04-07

申请人： Gilead Sciences, Inc.

发明人： Gayatri Balan ,  Peter A. Blomgren ,  Chen Chen ,  Julian A. Codelli ,  Zhimin Du ,  Musong Kim ,  Dorothée Saddier Axe ,  Gregg M. Schwarzwalder ,  Rhiannon Thomas-Tran ,  Michael T. Tudesco ,  Chandrasekar Venkataramani ,  William J. Watkins ,  Brian M. Weist ,  Suet C. Yeung ,  Helen Yu

IPC分类号： C07D401/04

CPC分类号： C07D401/04 ,  C07B2200/05 ,  C07D401/04 ,  C07B2200/05

摘要： The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zinc Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2 and/or IKZF4, including cancer.