Technologies disclosed herein provide cryptographic computing. An example method comprises executing a first instruction of a first software entity to receive a first input operand indicating a first key associated with a first memory compartment of a plurality of memory compartments stored in a first memory unit, and execute a cryptographic algorithm in a core of a processor to compute first encrypted contents based at least in part on the first key. Subsequent to computing the first encrypted contents in the core, the first encrypted contents are stored at a memory location in the first memory compartment of the first memory unit. More specific embodiments include, prior to storing the first encrypted contents at the memory location in the first memory compartment and subsequent to computing the first encrypted contents in the core, moving the first encrypted contents into a level one (L1) cache outside a boundary of the core.