Invention Grant
- Patent Title: Identification of porcine xenoantigens
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Application No.: US17684207Application Date: 2022-03-01
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Publication No.: US12207629B2Publication Date: 2025-01-28
- Inventor: Burcin Ekser , Ping Li
- Applicant: Indiana University Research and Technology Corporation
- Applicant Address: US IN Indianapolis
- Assignee: Indiana University Research and Technology Corporation
- Current Assignee: Indiana University Research and Technology Corporation
- Current Assignee Address: US IN Indianapolis
- Agency: Quarles & Brady, LLP
- Main IPC: C12N5/071
- IPC: C12N5/071 ; A01K67/0278 ; A61K35/12 ; A61P43/00 ; C12N9/10 ; C12N15/90
Abstract:
Provided herein are genetically modified pigs, porcine organs, tissue, and cells having a reduced propensity to cause a rejection response in a human subject following xenotransplantation. In particular, provided herein are genetically modified pigs lacking nonGal xenoantigens, and porcine cells, tissues, and organs obtained from such genetically modified pigs that are suitable for transplantation into a human. Also provided herein are methods of improving a rejection related symptom in a human subject.
Public/Granted literature
- US20220183262A1 Identification of Porcine Xenoantigens Public/Granted day:2022-06-16
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