公开(公告)号：US11479752B2

公开(公告)日：2022-10-25

申请号：US16162921

申请日：2018-10-17

Applicant: Indiana University Research and Technology Corporation

Inventor： Burcin Ekser

IPC: C12N5/00 ,  B33Y80/00 ,  C12N5/071 ,  G01N33/50 ,  B33Y10/00 ,  B33Y70/00 ,  A61L27/38

Abstract: Provided herein are synthetic, three-dimensional (3D) bioprinted tissue constructs comprising porcine cells and methods of producing and using the same. The synthetic 3D bioprinted tissue constructs are fabricated by bioprinting spheroids comprising porcine cells, including genetically engineered cells, on a microneedle mold and fusing the spheroids to form an engineered tissue construct. Also provided are methods of using scaffold-free 3D bioprinted tissue constructs for applications related to drug screening and toxicity screening.

公开(公告)号：US20220220435A1

公开(公告)日：2022-07-14

申请号：US17689251

申请日：2022-03-08

Applicant: Indiana University Research and Technology Corporation

Inventor： Burcin Ekser

IPC: C12N5/00 ,  B33Y80/00 ,  C12N5/071 ,  G01N33/50 ,  B33Y10/00 ,  B33Y70/00 ,  A61L27/38

Abstract: Provided herein are synthetic, three-dimensional (3D) bioprinted tissue constructs comprising porcine cells and methods of producing and using the same. The synthetic 3D bioprinted tissue constructs are fabricated by bioprinting spheroids comprising porcine cells, including genetically engineered cells, on a microneedle mold and fusing the spheroids to form an engineered tissue construct. Also provided are methods of using scaffold-free 3D bioprinted tissue constructs for applications related to drug screening and toxicity screening.

公开(公告)号：US12207629B2

公开(公告)日：2025-01-28

申请号：US17684207

申请日：2022-03-01

Applicant: Indiana University Research and Technology Corporation

Inventor： Burcin Ekser ,  Ping Li

IPC: C12N5/071 ,  A01K67/0278 ,  A61K35/12 ,  A61P43/00 ,  C12N9/10 ,  C12N15/90

Abstract: Provided herein are genetically modified pigs, porcine organs, tissue, and cells having a reduced propensity to cause a rejection response in a human subject following xenotransplantation. In particular, provided herein are genetically modified pigs lacking nonGal xenoantigens, and porcine cells, tissues, and organs obtained from such genetically modified pigs that are suitable for transplantation into a human. Also provided herein are methods of improving a rejection related symptom in a human subject.

公开(公告)号：US20220183262A1

公开(公告)日：2022-06-16

申请号：US17684207

申请日：2022-03-01

Applicant: Indiana University Research and Technology Corporation

Inventor： Burcin Ekser

IPC: A01K67/027 ,  A61K35/12 ,  A61P43/00

Abstract: Provided herein are genetically modified pigs, porcine organs, tissue, and cells having a reduced propensity to cause a rejection response in a human subject following xenotransplantation. In particular, provided herein are genetically modified pigs lacking nonGal xenoantigens, and porcine cells, tissues, and organs obtained from such genetically modified pigs that are suitable for transplantation into a human. Also provided herein are methods of improving a rejection related symptom in a human subject.

公开(公告)号：US20190119626A1

公开(公告)日：2019-04-25

申请号：US16162921

申请日：2018-10-17

Applicant: Indiana University Research and Technology Corporation

Inventor： Burcin Ekser

IPC: C12N5/00 ,  G01N33/50 ,  A61L27/38 ,  B33Y10/00 ,  B33Y70/00

Abstract: Provided herein are synthetic, three-dimensional (3D) bioprinted tissue constructs comprising porcine cells and methods of producing and using the same. The synthetic 3D bioprinted tissue constructs are fabricated by bioprinting spheroids comprising porcine cells, including genetically engineered cells, on a microneedle mold and fusing the spheroids to form an engineered tissue construct. Also provided are methods of using scaffold-free 3D bioprinted tissue constructs for applications related to drug screening and toxicity screening.