公开(公告)号：US12207629B2

公开(公告)日：2025-01-28

申请号：US17684207

申请日：2022-03-01

Applicant: Indiana University Research and Technology Corporation

Inventor： Burcin Ekser ,  Ping Li

IPC: C12N5/071 ,  A01K67/0278 ,  A61K35/12 ,  A61P43/00 ,  C12N9/10 ,  C12N15/90

Abstract: Provided herein are genetically modified pigs, porcine organs, tissue, and cells having a reduced propensity to cause a rejection response in a human subject following xenotransplantation. In particular, provided herein are genetically modified pigs lacking nonGal xenoantigens, and porcine cells, tissues, and organs obtained from such genetically modified pigs that are suitable for transplantation into a human. Also provided herein are methods of improving a rejection related symptom in a human subject.