发明申请
- 专利标题: Modulators of peroxisome proliferator activated receptors
- 专利标题(中): 过氧化物酶体增殖物激活受体的调节剂
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申请号: US10479262申请日: 2002-05-30
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公开(公告)号: US20050020684A1公开(公告)日: 2005-01-27
- 发明人: Dawn Brooks , Alan Warshawsky , Chahrzad Montrose-Rafezadeh , Anne-Reifel Miller , Lourdes Prieto , Isabel Rojo , Jose Alfredo Martin , Maria Rosario Gonzales Garcia , Alicia Torrado , Rafael Crespo , Carlos Lamas-Peteira , Robert Ardecky , Maria Martin-Ortega Finger
- 申请人: Dawn Brooks , Alan Warshawsky , Chahrzad Montrose-Rafezadeh , Anne-Reifel Miller , Lourdes Prieto , Isabel Rojo , Jose Alfredo Martin , Maria Rosario Gonzales Garcia , Alicia Torrado , Rafael Crespo , Carlos Lamas-Peteira , Robert Ardecky , Maria Martin-Ortega Finger
- 国际申请: PCT/US02/16950 WO 20020530
- 主分类号: C07D295/08
- IPC分类号: C07D295/08 ; A61K31/19 ; A61K31/275 ; A61K31/343 ; A61K31/352 ; A61K31/353 ; A61K31/36 ; A61K31/381 ; A61K31/40 ; A61K31/4035 ; A61K31/404 ; A61K31/41 ; A61K31/4164 ; A61K31/428 ; A61K31/4402 ; A61K31/4406 ; A61K31/4409 ; A61K31/4453 ; A61K31/47 ; A61K31/472 ; A61K31/495 ; A61K31/5375 ; A61K45/00 ; A61P1/14 ; A61P3/00 ; A61P3/04 ; A61P3/06 ; A61P3/10 ; A61P9/00 ; A61P9/04 ; A61P9/12 ; A61P15/00 ; C07B61/00 ; C07C51/09 ; C07C59/68 ; C07C59/72 ; C07C59/90 ; C07C213/08 ; C07C217/20 ; C07C217/84 ; C07C217/92 ; C07C219/10 ; C07C233/25 ; C07C233/29 ; C07C233/60 ; C07C233/75 ; C07C235/56 ; C07C235/64 ; C07C239/12 ; C07C251/48 ; C07C255/54 ; C07D209/08 ; C07D209/48 ; C07D213/30 ; C07D213/64 ; C07D213/82 ; C07D215/12 ; C07D215/14 ; C07D217/02 ; C07D233/60 ; C07D257/04 ; C07D277/64 ; C07D295/096 ; C07D295/10 ; C07D295/112 ; C07D295/185 ; C07D307/79 ; C07D307/83 ; C07D307/91 ; C07D307/93 ; C07D311/30 ; C07D311/32 ; C07D317/20 ; C07D317/22 ; C07D317/54 ; C07D317/64 ; C07D333/16 ; C07D333/76 ; C07D335/02 ; C07D521/00 ; C07F7/18 ; A61K31/195 ; C07C233/87
摘要:
Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, —CH2— or —CH2CH2—; W is a substituted or unsubstituted alkylene or a substituted or unsubstituted heteroalkylene linking group from two to ten atoms in length, preferably from two to seven atoms in length. Phenyl Ring A is optionally substituted with up to four substituents in addition to R1 and W, R2 is (CH2)n—CH(OR2)—(CH2)nE, —(CH)═C(OR2)—(CH2)nE, —(CH2)n—CH(Y)—(CH2)mE or (CH)═C(Y)(CH2)mE; wherein E is COOR3, C1-C3 alkylnitrile, carboxamide, sulfonamide, acylsulfonamide or tetrazole and wherein sulfonamide, acylsulfonamide and tetrazole are optionally substituted with one or more substituents independently selected from: C1-C6 alkyl, haloalkyl and aryl-Co-4-alkyl; R2 is H, an aliphatic group, a substituted aliphatic group, haloalkyl, an aromatic group, a substituted aromatic group, —COR4, —COOR4, —CONR5R6, —C(S)R4, —C(S)OR4 or C(S)NR5R6, R3 is H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. Y is O—, CH2—, CH2CH2— or CH═CH— and is bonded to a carbon atom in Phenyl Ring A that is ortho to R1. R4-R6 are independently H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. n and m are independently 0, 1 or 2.
公开/授权文献
- US07192982B2 Modulators of peroxisome proliferator activated receptors 公开/授权日:2007-03-20