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公开(公告)号：US20050020684A1
公开(公告)日：2005-01-27
申请号：US10479262
申请日：2002-05-30
申请人： Dawn Brooks , Alan Warshawsky , Chahrzad Montrose-Rafezadeh , Anne-Reifel Miller , Lourdes Prieto , Isabel Rojo , Jose Alfredo Martin , Maria Rosario Gonzales Garcia , Alicia Torrado , Rafael Crespo , Carlos Lamas-Peteira , Robert Ardecky , Maria Martin-Ortega Finger
发明人： Dawn Brooks , Alan Warshawsky , Chahrzad Montrose-Rafezadeh , Anne-Reifel Miller , Lourdes Prieto , Isabel Rojo , Jose Alfredo Martin , Maria Rosario Gonzales Garcia , Alicia Torrado , Rafael Crespo , Carlos Lamas-Peteira , Robert Ardecky , Maria Martin-Ortega Finger
IPC分类号： C07D295/08 , A61K31/19 , A61K31/275 , A61K31/343 , A61K31/352 , A61K31/353 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/4035 , A61K31/404 , A61K31/41 , A61K31/4164 , A61K31/428 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4453 , A61K31/47 , A61K31/472 , A61K31/495 , A61K31/5375 , A61K45/00 , A61P1/14 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/04 , A61P9/12 , A61P15/00 , C07B61/00 , C07C51/09 , C07C59/68 , C07C59/72 , C07C59/90 , C07C213/08 , C07C217/20 , C07C217/84 , C07C217/92 , C07C219/10 , C07C233/25 , C07C233/29 , C07C233/60 , C07C233/75 , C07C235/56 , C07C235/64 , C07C239/12 , C07C251/48 , C07C255/54 , C07D209/08 , C07D209/48 , C07D213/30 , C07D213/64 , C07D213/82 , C07D215/12 , C07D215/14 , C07D217/02 , C07D233/60 , C07D257/04 , C07D277/64 , C07D295/096 , C07D295/10 , C07D295/112 , C07D295/185 , C07D307/79 , C07D307/83 , C07D307/91 , C07D307/93 , C07D311/30 , C07D311/32 , C07D317/20 , C07D317/22 , C07D317/54 , C07D317/64 , C07D333/16 , C07D333/76 , C07D335/02 , C07D521/00 , C07F7/18 , A61K31/195 , C07C233/87
CPC分类号： C07D209/48 , C07C59/68 , C07C59/72 , C07C59/90 , C07C217/20 , C07C217/84 , C07C217/92 , C07C219/10 , C07C233/25 , C07C233/29 , C07C233/60 , C07C233/75 , C07C235/56 , C07C235/64 , C07C239/12 , C07C255/54 , C07C2601/08 , C07D209/08 , C07D213/30 , C07D215/14 , C07D217/02 , C07D231/12 , C07D233/56 , C07D249/08 , C07D257/04 , C07D277/64 , C07D295/096 , C07D295/112 , C07D295/185 , C07D307/79 , C07D307/83 , C07D307/91 , C07D307/93 , C07D311/30 , C07D317/20 , C07D317/22 , C07D317/54 , C07D317/64 , C07D333/16 , C07D333/76 , C07D335/02
摘要： Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, —CH2— or —CH2CH2—; W is a substituted or unsubstituted alkylene or a substituted or unsubstituted heteroalkylene linking group from two to ten atoms in length, preferably from two to seven atoms in length. Phenyl Ring A is optionally substituted with up to four substituents in addition to R1 and W, R2 is (CH2)n—CH(OR2)—(CH2)nE, —(CH)═C(OR2)—(CH2)nE, —(CH2)n—CH(Y)—(CH2)mE or (CH)═C(Y)(CH2)mE; wherein E is COOR3, C1-C3 alkylnitrile, carboxamide, sulfonamide, acylsulfonamide or tetrazole and wherein sulfonamide, acylsulfonamide and tetrazole are optionally substituted with one or more substituents independently selected from: C1-C6 alkyl, haloalkyl and aryl-Co-4-alkyl; R2 is H, an aliphatic group, a substituted aliphatic group, haloalkyl, an aromatic group, a substituted aromatic group, —COR4, —COOR4, —CONR5R6, —C(S)R4, —C(S)OR4 or C(S)NR5R6, R3 is H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. Y is O—, CH2—, CH2CH2— or CH═CH— and is bonded to a carbon atom in Phenyl Ring A that is ortho to R1. R4-R6 are independently H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. n and m are independently 0, 1 or 2.
摘要翻译： 公开了由结构式（I）表示的化合物：Ar是取代或未取代的芳基。 Q是共价键，-CH 2 - 或-CH 2 CH 2 - ; W是长度为2至10个原子，优选2至7个长度的取代或未取代的亚烷基或取代或未取代的亚烷基连接基团。 除了R 1和W之外，苯环A任选被至多四个取代基取代，R 2是（CH 2）n -CH（OR 2） - （CH 2）nE， - （CH）= C（OR 2） - （CH 2） - （CH 2）n -CH（Y） - （CH 2）mE或（CH）= C（Y）（CH 2）mE; 其中E是COOR 3，C 1 -C 3烷基腈，甲酰胺，磺酰胺，酰基磺酰胺或四唑，其中磺酰胺，酰基磺酰胺和四唑任选地被一个或多个独立地选自：C 1 -C 6烷基，卤代烷基和芳基-C 1-4 - ; R 2是H，脂族基团，取代的脂族基团，卤代烷基，芳族基团，取代的芳族基团，-COR 4，-COOR 4，-CONR 5 R 6，-C（S）R 4，-C（S）OR 4或C ）NR 5 R 6，R 3为H，脂族基团，取代的脂族基团，芳族基团或取代的芳族基团。 Y是O-，CH 2 - ，CH 2 CH 2 - 或CH = CH-，并且与R 1邻位的苯基环A中的碳原子键合。 R 4 -R 6独立地为H，脂族基团，取代的脂族基团，芳族基团或取代的芳族基团。 n和m独立地为0,1或2。
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公开(公告)号：US07192982B2
公开(公告)日：2007-03-20
申请号：US10479262
申请日：2002-05-30
申请人： Dawn Alisa Brooks , Alan M. Warshawsky , Chahrzad Montrose-Rafezadeh , Anne-Reifel Miller , Lourdes Prieto , Isabel Rojo , Jose Alfredo Martin , Maria Rosario Gonzales Garcia , Alicia Torrado , Rafael Ferritto Crespo , Carlos Lamas-Peteira , Robert J. Ardecky , Maria Martin-Ortega Finger
发明人： Dawn Alisa Brooks , Alan M. Warshawsky , Chahrzad Montrose-Rafezadeh , Anne-Reifel Miller , Lourdes Prieto , Isabel Rojo , Jose Alfredo Martin , Maria Rosario Gonzales Garcia , Alicia Torrado , Rafael Ferritto Crespo , Carlos Lamas-Peteira , Robert J. Ardecky , Maria Martin-Ortega Finger
CPC分类号： C07D209/48 , C07C59/68 , C07C59/72 , C07C59/90 , C07C217/20 , C07C217/84 , C07C217/92 , C07C219/10 , C07C233/25 , C07C233/29 , C07C233/60 , C07C233/75 , C07C235/56 , C07C235/64 , C07C239/12 , C07C255/54 , C07C2601/08 , C07D209/08 , C07D213/30 , C07D215/14 , C07D217/02 , C07D231/12 , C07D233/56 , C07D249/08 , C07D257/04 , C07D277/64 , C07D295/096 , C07D295/112 , C07D295/185 , C07D307/79 , C07D307/83 , C07D307/91 , C07D307/93 , C07D311/30 , C07D317/20 , C07D317/22 , C07D317/54 , C07D317/64 , C07D333/16 , C07D333/76 , C07D335/02
摘要： Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, —CH2— or —CH2CH2—; W is a substituted or unsubstituted alkylene or a substituted or unsubstituted heteroalkylene linking group from two to ten atoms in length, preferably from two to seven atoms in length. Phenyl Ring A is optionally substituted with up to four substituents in addition to R1 and W, R1 is (CH2)n—CH(OR2)—(CH2)mE1, —(CH)═C(OR2)—(CH2)mE, —(CH2)n—CH(Y)—(CH2)mE or (CH)═C(Y)—(CH2)mE; wherein E is COOR3, C1–C3 alkylnitrile, carboxamide, sulfonamide, acylsulfonamide or tetrazole and wherein sulfonamide, acylsulfonamide and tetrazole are optionally substituted with one or more substituents independently selected from: C1–C6 alkyl, haloalkyl and aryl-C0-4-alkyl; R2 is H, an aliphatic group, a substituted aliphatic group, haloalkyl, an aromatic group, a substituted aromatic group, —COR4, —COOR4, —CONR5R6, —C(S)R4, —C(S)OR4 or C(S)NR5R6, R3 is H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. Y is O—, CH2—, —CH2CH2— or CH═CH— and is bonded to a carbon atom in Phenyl Ring A that is ortho to R1. R4–R6 are independently H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. n and m are independently 0, 1 or 2
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公开(公告)号：US20070276138A1
公开(公告)日：2007-11-29
申请号：US11637223
申请日：2006-12-11
申请人： Dawn Brooks , Alan Warshawsky , Chahrzad Montrose-Rafezadeh , Anne Reifel-Miller , Lourdes Prieto , Isabel Rojo , Jose Martin , Maria Gonzales Garcia , Alicia Torrado , Rafael Crespo , Carlos Lamas-Peteira , Robert Ardecky , Maria Finger
发明人： Dawn Brooks , Alan Warshawsky , Chahrzad Montrose-Rafezadeh , Anne Reifel-Miller , Lourdes Prieto , Isabel Rojo , Jose Martin , Maria Gonzales Garcia , Alicia Torrado , Rafael Crespo , Carlos Lamas-Peteira , Robert Ardecky , Maria Finger
IPC分类号： C07D265/30 , C07C233/87 , C07D207/02 , C07D209/04 , C07D209/32 , C07D211/40 , C07D277/62 , C07D307/87 , C07D317/06 , C07D333/76 , C07D333/08 , C07D333/02 , C07D317/70 , C07D311/30 , C07D307/02 , C07D215/20 , C07D217/02 , C07D233/02 , C07D241/04 , C07D257/04
CPC分类号： C07D209/48 , C07C59/68 , C07C59/72 , C07C59/90 , C07C217/20 , C07C217/84 , C07C217/92 , C07C219/10 , C07C233/25 , C07C233/29 , C07C233/60 , C07C233/75 , C07C235/56 , C07C235/64 , C07C239/12 , C07C255/54 , C07C2601/08 , C07D209/08 , C07D213/30 , C07D215/14 , C07D217/02 , C07D231/12 , C07D233/56 , C07D249/08 , C07D257/04 , C07D277/64 , C07D295/096 , C07D295/112 , C07D295/185 , C07D307/79 , C07D307/83 , C07D307/91 , C07D307/93 , C07D311/30 , C07D317/20 , C07D317/22 , C07D317/54 , C07D317/64 , C07D333/16 , C07D333/76 , C07D335/02
摘要： Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, —CH2— or —CH2CH2—; W is a substituted or unsubstituted alkylene or a substituted or unsubstituted heteroalkylene linking group from two to ten atoms in length, preferably from two to seven atoms in length. Phenyl Ring A is optionally substituted with up to four substituents in addition to R1 and W. R1 is —(CH2)n—CH(OR2)—(CH2)mE, —(CH)═C(OR2)—(CH2)mE, —(CH2)n—CH(Y)—(CH2)mE or —(CH)═C(Y)—(CH2)mE; wherein E is COOR3, C1-C3-alkylnitrile, carboxamide, sulfonamide, acylsulfonamide or tetrazole and wherein sulfonamide, acylsulfonamide and tetrazole are optionally substituted with one or more substituents independently selected from: C1-C6 alkyl, haloalkyl and aryl-C0-4-alkyl; R2 is —H, an aliphatic group, a substituted aliphatic group, haloalkyl, an aromatic group, a substituted aromatic group, —COR4, —COOR4, —CONR5R6, —C(S)R4, —C(S)OR4 or —C(S)NR5R6. R3 is —H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. Y is —O—, —CH2—, —CH2CH2— or —CH═CH— and is bonded to a carbon atom in Phenyl Ring A that is ortho to R1. R4-R6 are independently —H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. n and m are independently 0, 1 or 2.
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