公开(公告)号：US20050020684A1

公开(公告)日：2005-01-27

申请号：US10479262

申请日：2002-05-30

申请人： Dawn Brooks ,  Alan Warshawsky ,  Chahrzad Montrose-Rafezadeh ,  Anne-Reifel Miller ,  Lourdes Prieto ,  Isabel Rojo ,  Jose Alfredo Martin ,  Maria Rosario Gonzales Garcia ,  Alicia Torrado ,  Rafael Crespo ,  Carlos Lamas-Peteira ,  Robert Ardecky ,  Maria Martin-Ortega Finger

发明人： Dawn Brooks ,  Alan Warshawsky ,  Chahrzad Montrose-Rafezadeh ,  Anne-Reifel Miller ,  Lourdes Prieto ,  Isabel Rojo ,  Jose Alfredo Martin ,  Maria Rosario Gonzales Garcia ,  Alicia Torrado ,  Rafael Crespo ,  Carlos Lamas-Peteira ,  Robert Ardecky ,  Maria Martin-Ortega Finger

IPC分类号： C07D295/08 ,  A61K31/19 ,  A61K31/275 ,  A61K31/343 ,  A61K31/352 ,  A61K31/353 ,  A61K31/36 ,  A61K31/381 ,  A61K31/40 ,  A61K31/4035 ,  A61K31/404 ,  A61K31/41 ,  A61K31/4164 ,  A61K31/428 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4453 ,  A61K31/47 ,  A61K31/472 ,  A61K31/495 ,  A61K31/5375 ,  A61K45/00 ,  A61P1/14 ,  A61P3/00 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P9/04 ,  A61P9/12 ,  A61P15/00 ,  C07B61/00 ,  C07C51/09 ,  C07C59/68 ,  C07C59/72 ,  C07C59/90 ,  C07C213/08 ,  C07C217/20 ,  C07C217/84 ,  C07C217/92 ,  C07C219/10 ,  C07C233/25 ,  C07C233/29 ,  C07C233/60 ,  C07C233/75 ,  C07C235/56 ,  C07C235/64 ,  C07C239/12 ,  C07C251/48 ,  C07C255/54 ,  C07D209/08 ,  C07D209/48 ,  C07D213/30 ,  C07D213/64 ,  C07D213/82 ,  C07D215/12 ,  C07D215/14 ,  C07D217/02 ,  C07D233/60 ,  C07D257/04 ,  C07D277/64 ,  C07D295/096 ,  C07D295/10 ,  C07D295/112 ,  C07D295/185 ,  C07D307/79 ,  C07D307/83 ,  C07D307/91 ,  C07D307/93 ,  C07D311/30 ,  C07D311/32 ,  C07D317/20 ,  C07D317/22 ,  C07D317/54 ,  C07D317/64 ,  C07D333/16 ,  C07D333/76 ,  C07D335/02 ,  C07D521/00 ,  C07F7/18 ,  A61K31/195 ,  C07C233/87

CPC分类号： C07D209/48 ,  C07C59/68 ,  C07C59/72 ,  C07C59/90 ,  C07C217/20 ,  C07C217/84 ,  C07C217/92 ,  C07C219/10 ,  C07C233/25 ,  C07C233/29 ,  C07C233/60 ,  C07C233/75 ,  C07C235/56 ,  C07C235/64 ,  C07C239/12 ,  C07C255/54 ,  C07C2601/08 ,  C07D209/08 ,  C07D213/30 ,  C07D215/14 ,  C07D217/02 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D257/04 ,  C07D277/64 ,  C07D295/096 ,  C07D295/112 ,  C07D295/185 ,  C07D307/79 ,  C07D307/83 ,  C07D307/91 ,  C07D307/93 ,  C07D311/30 ,  C07D317/20 ,  C07D317/22 ,  C07D317/54 ,  C07D317/64 ,  C07D333/16 ,  C07D333/76 ,  C07D335/02

摘要： Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, —CH2— or —CH2CH2—; W is a substituted or unsubstituted alkylene or a substituted or unsubstituted heteroalkylene linking group from two to ten atoms in length, preferably from two to seven atoms in length. Phenyl Ring A is optionally substituted with up to four substituents in addition to R1 and W, R2 is (CH2)n—CH(OR2)—(CH2)nE, —(CH)═C(OR2)—(CH2)nE, —(CH2)n—CH(Y)—(CH2)mE or (CH)═C(Y)(CH2)mE; wherein E is COOR3, C1-C3 alkylnitrile, carboxamide, sulfonamide, acylsulfonamide or tetrazole and wherein sulfonamide, acylsulfonamide and tetrazole are optionally substituted with one or more substituents independently selected from: C1-C6 alkyl, haloalkyl and aryl-Co-4-alkyl; R2 is H, an aliphatic group, a substituted aliphatic group, haloalkyl, an aromatic group, a substituted aromatic group, —COR4, —COOR4, —CONR5R6, —C(S)R4, —C(S)OR4 or C(S)NR5R6, R3 is H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. Y is O—, CH2—, CH2CH2— or CH═CH— and is bonded to a carbon atom in Phenyl Ring A that is ortho to R1. R4-R6 are independently H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. n and m are independently 0, 1 or 2.

摘要翻译： 公开了由结构式（I）表示的化合物：Ar是取代或未取代的芳基。 Q是共价键，-CH 2 - 或-CH 2 CH 2 - ; W是长度为2至10个原子，优选2至7个长度的取代或未取代的亚烷基或取代或未取代的亚烷基连接基团。 除了R 1和W之外，苯环A任选被至多四个取代基取代，R 2是（CH 2）n -CH（OR 2） - （CH 2）nE， - （CH）= C（OR 2） - （CH 2） - （CH 2）n -CH（Y） - （CH 2）mE或（CH）= C（Y）（CH 2）mE; 其中E是COOR 3，C 1 -C 3烷基腈，甲酰胺，磺酰胺，酰基磺酰胺或四唑，其中磺酰胺，酰基磺酰胺和四唑任选地被一个或多个独立地选自：C 1 -C 6烷基，卤代烷基和芳基-C 1-4 - ; R 2是H，脂族基团，取代的脂族基团，卤代烷基，芳族基团，取代的芳族基团，-COR 4，-COOR 4，-CONR 5 R 6，-C（S）R 4，-C（S）OR 4或C ）NR 5 R 6，R 3为H，脂族基团，取代的脂族基团，芳族基团或取代的芳族基团。 Y是O-，CH 2 - ，CH 2 CH 2 - 或CH = CH-，并且与R 1邻位的苯基环A中的碳原子键合。 R 4 -R 6独立地为H，脂族基团，取代的脂族基团，芳族基团或取代的芳族基团。 n和m独立地为0,1或2。

公开(公告)号：US07192982B2

公开(公告)日：2007-03-20

申请号：US10479262

申请日：2002-05-30

申请人： Dawn Alisa Brooks ,  Alan M. Warshawsky ,  Chahrzad Montrose-Rafezadeh ,  Anne-Reifel Miller ,  Lourdes Prieto ,  Isabel Rojo ,  Jose Alfredo Martin ,  Maria Rosario Gonzales Garcia ,  Alicia Torrado ,  Rafael Ferritto Crespo ,  Carlos Lamas-Peteira ,  Robert J. Ardecky ,  Maria Martin-Ortega Finger

发明人： Dawn Alisa Brooks ,  Alan M. Warshawsky ,  Chahrzad Montrose-Rafezadeh ,  Anne-Reifel Miller ,  Lourdes Prieto ,  Isabel Rojo ,  Jose Alfredo Martin ,  Maria Rosario Gonzales Garcia ,  Alicia Torrado ,  Rafael Ferritto Crespo ,  Carlos Lamas-Peteira ,  Robert J. Ardecky ,  Maria Martin-Ortega Finger

IPC分类号： A61K37/00 ,  C07C59/00

CPC分类号： C07D209/48 ,  C07C59/68 ,  C07C59/72 ,  C07C59/90 ,  C07C217/20 ,  C07C217/84 ,  C07C217/92 ,  C07C219/10 ,  C07C233/25 ,  C07C233/29 ,  C07C233/60 ,  C07C233/75 ,  C07C235/56 ,  C07C235/64 ,  C07C239/12 ,  C07C255/54 ,  C07C2601/08 ,  C07D209/08 ,  C07D213/30 ,  C07D215/14 ,  C07D217/02 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D257/04 ,  C07D277/64 ,  C07D295/096 ,  C07D295/112 ,  C07D295/185 ,  C07D307/79 ,  C07D307/83 ,  C07D307/91 ,  C07D307/93 ,  C07D311/30 ,  C07D317/20 ,  C07D317/22 ,  C07D317/54 ,  C07D317/64 ,  C07D333/16 ,  C07D333/76 ,  C07D335/02

摘要： Disclosed is a compound represented by Structural Formula (I): Ar is a substituted or unsubstituted aromatic group. Q is a covalent bond, —CH2— or —CH2CH2—; W is a substituted or unsubstituted alkylene or a substituted or unsubstituted heteroalkylene linking group from two to ten atoms in length, preferably from two to seven atoms in length. Phenyl Ring A is optionally substituted with up to four substituents in addition to R1 and W, R1 is (CH2)n—CH(OR2)—(CH2)mE1, —(CH)═C(OR2)—(CH2)mE, —(CH2)n—CH(Y)—(CH2)mE or (CH)═C(Y)—(CH2)mE; wherein E is COOR3, C1–C3 alkylnitrile, carboxamide, sulfonamide, acylsulfonamide or tetrazole and wherein sulfonamide, acylsulfonamide and tetrazole are optionally substituted with one or more substituents independently selected from: C1–C6 alkyl, haloalkyl and aryl-C0-4-alkyl; R2 is H, an aliphatic group, a substituted aliphatic group, haloalkyl, an aromatic group, a substituted aromatic group, —COR4, —COOR4, —CONR5R6, —C(S)R4, —C(S)OR4 or C(S)NR5R6, R3 is H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. Y is O—, CH2—, —CH2CH2— or CH═CH— and is bonded to a carbon atom in Phenyl Ring A that is ortho to R1. R4–R6 are independently H, an aliphatic group, a substituted aliphatic group, an aromatic group or a substituted aromatic group. n and m are independently 0, 1 or 2

公开(公告)号：US20070066683A1

公开(公告)日：2007-03-22

申请号：US10596256

申请日：2004-12-08

申请人： Rafael Ferritto Crespo ,  Maria Martin-Ortega Finger

发明人： Rafael Ferritto Crespo ,  Maria Martin-Ortega Finger

IPC分类号： A61K31/195 ,  C07C237/20

CPC分类号： C07C235/08 ,  C07C235/20

摘要： The present invention is directed to a novel compound, its composition and use of a compound having a structural formula (I), or a pharmaceutically acceptable salt, solvate, hydrate or stereoisomers thereof, which is useful in treating or preventing disorders mediated by a peroxisome proliferator activated receptor (PPAR) such as syndrome X, type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, arteriosclerosis, and other disorders related to syndrome X and cardiovascular diseases.

摘要翻译： 本发明涉及一种新型化合物，其组合物和具有结构式（I）化合物或其药学上可接受的盐，溶剂合物，水合物或立体异构体的组合物和用途，其可用于治疗或预防由过氧化物酶体介导的病症 增殖激活受体（PPAR）如X综合征，II型糖尿病，高血糖症，高脂血症，肥胖症，凝血病，高血压，动脉硬化以及与X和心血管疾病相关的其他疾病。