发明申请
- 专利标题: Design of artificial genes for use as controls in gene expression analysis systems
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申请号: US11013179申请日: 2004-12-15
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公开(公告)号: US20050095640A1公开(公告)日: 2005-05-05
- 发明人: Hrissi Samartzidou , Leah Turner , Steven Daniel , Thomas Houts
- 申请人: Hrissi Samartzidou , Leah Turner , Steven Daniel , Thomas Houts
- 专利权人: Amersham Biosciences Corp.
- 当前专利权人: Amersham Biosciences Corp.
- 主分类号: C12N15/09
- IPC分类号: C12N15/09 ; C07H21/02 ; C07H21/04 ; C12P19/34 ; C12Q1/68
摘要:
Method of producing controls for use in gene expression analysis systems such as macroarrays, real-time PCR, northern blots, SAGE and microarrays. The controls are generated either from near-random sequence of DNA, or from inter- or intragenic regions of a genome. Ten specific control sequences are also disclosed. Also presented are methods of using these controls, including as negative controls, positive controls, and as calibrators of a gene expression analysis system.