Invention Application
- Patent Title: Prodrugs of phosphonate nucleotide analogues
- Patent Title (中): 膦酸酯核苷酸类似物的前药
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Application No.: US11031250Application Date: 2005-01-06
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Publication No.: US20050124583A1Publication Date: 2005-06-09
- Inventor: Mark Becker , Harlan Chapman , Tomas Clhlar , Eugene Elsenberg , Gong-Xin He , Michael Kernan , William Lee , Ernest Prisbe , John Rohloff , Mark Sparacino
- Applicant: Mark Becker , Harlan Chapman , Tomas Clhlar , Eugene Elsenberg , Gong-Xin He , Michael Kernan , William Lee , Ernest Prisbe , John Rohloff , Mark Sparacino
- Main IPC: A61K31/664
- IPC: A61K31/664 ; A61K31/675 ; A61P31/12 ; A61P31/18 ; A61P35/00 ; C07F9/6561 ; C07H19/10 ; C07H19/20 ; C07H21/00 ; C12Q1/18 ; G01N33/15 ; G01N33/50 ; G01N33/53
Abstract:
A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided.
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