专利检索 ap:("Mark Becker" OR "Harlan Chapman" OR "Tomas Clhlar" OR "Eugene Elsenberg" OR "Gong-Xin He" OR "Michael Kernan" OR "William Lee" OR "Ernest Prisbe" OR "John Rohloff" OR "Mark Sparacino") AND inv:"Harlan Chapman" 第 1 页

1.

发明申请
Prodrugs of phosphonate nucleotide analogues 审中-公开
标题翻译：膦酸酯核苷酸类似物的前药

公开(公告)号：US20050124583A1

公开(公告)日：2005-06-09

申请号：US11031250

申请日：2005-01-06

申请人： Mark Becker , Harlan Chapman , Tomas Clhlar , Eugene Elsenberg , Gong-Xin He , Michael Kernan , William Lee , Ernest Prisbe , John Rohloff , Mark Sparacino

发明人： Mark Becker , Harlan Chapman , Tomas Clhlar , Eugene Elsenberg , Gong-Xin He , Michael Kernan , William Lee , Ernest Prisbe , John Rohloff , Mark Sparacino

IPC分类号： A61K31/664 , A61K31/675 , A61P31/12 , A61P31/18 , A61P35/00 , C07F9/6561 , C07H19/10 , C07H19/20 , C07H21/00 , C12Q1/18 , G01N33/15 , G01N33/50 , G01N33/53

CPC分类号： C07H19/10 , C07F9/65616 , C07H19/20 , C07H21/00 , C12Q1/18 , G01N33/5011

摘要： A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided.

摘要翻译： 一种新的方法导致鉴定用于逆转录病毒或肝炎病毒治疗的PMPA的新型混合酯酰胺化物，包括具有如本文所定义的取代基的结构（5a）的化合物。提供这些新化合物在药学上可接受的赋形剂中的组合物及其在治疗和预防中的用途。

2.

发明申请
Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same 审中-公开
标题翻译：膦酸酯核苷酸类似物的前体药物及其制备方法

公开(公告)号：US20060024659A1

公开(公告)日：2006-02-02

申请号：US10785497

申请日：2004-02-24

申请人： Mark Becker , Harlan Chapman , Tomas Cihlar , Eugene Eisenberg , Gong-Xin He , Michael Kernan , William Lee , Ernest Prisbe , John Rohloff , Mark Sparacino

发明人： Mark Becker , Harlan Chapman , Tomas Cihlar , Eugene Eisenberg , Gong-Xin He , Michael Kernan , William Lee , Ernest Prisbe , John Rohloff , Mark Sparacino

IPC分类号： C12Q1/00 , C12Q1/70

CPC分类号： C07H19/10 , C07F9/65616 , C07H19/20 , C07H21/00 , C12Q1/18 , G01N33/5011

摘要： A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided.

摘要翻译： 一种新的方法导致鉴定用于逆转录病毒或肝炎病毒治疗的PMPA的新型混合酯酰胺化物，包括具有如本文所定义的取代基的结构（5a）的化合物。提供这些新化合物在药学上可接受的赋形剂中的组合物及其在治疗和预防中的用途。