发明申请
- 专利标题： Compounds useful for inhibiting CHK1
- 专利标题（中）： 可用于抑制CHK1的化合物
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申请号： US11115993申请日： 2005-04-27
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公开(公告)号： US20050245525A1公开(公告)日： 2005-11-03
- 发明人: Kathleen Keegan , Edward Kesicki , John Gaudino , Adam Cook , Scott Cowen , Laurence Burgess
- 申请人： Kathleen Keegan , Edward Kesicki , John Gaudino , Adam Cook , Scott Cowen , Laurence Burgess
- 申请人地址： US WA Bothell
- 专利权人： ICOS CORPORATION
- 当前专利权人： ICOS CORPORATION
- 当前专利权人地址： US WA Bothell
- 主分类号： A61K31/4965
- IPC分类号： A61K31/4965 ; A61K31/497 ; A61K31/498 ; A61K31/5377 ; A61K45/06 ; A61P35/00 ; A61P43/00 ; C07D213/30 ; C07D213/40 ; C07D213/75 ; C07D213/77 ; C07D215/34 ; C07D231/40 ; C07D239/42 ; C07D239/46 ; C07D241/12 ; C07D241/20 ; C07D241/30 ; C07D241/44 ; C07D241/54 ; C07D251/22 ; C07D253/06 ; C07D253/07 ; C07D257/06 ; C07D277/48 ; C07D401/12 ; C07D401/14 ; C07D403/06 ; C07D403/12 ; C07D405/12 ; C07D409/12 ; C07D409/14 ; C07D453/02 ; C07D521/00 ; A61K31/53 ; A61K31/50
摘要：
Aryl- and heteroaryl-substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed.
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