摘要:
Multifunctional compounds are provided, comprising two or more functional moieties selected from: (i) a moiety that imparts an iron chelator function; (ii) a moiety that imparts a neuroprotective function; (iii) a moiety that imparts combined antiapoptotic, neuroprotective and/or neurorestorative functions; (iv) a moiety that imparts brain MAO inhibition, preferably with little or no MAO inhibition in liver and small intestine; (v) a moiety that imparts cholinesterase inhibitory function; and (vi) a moiety that imparts an N-methyl-D-aspartic acid receptor (NMDAR) inhibition, and pharmaceutically acceptable salts and optical isomers thereof. The multifunctional compounds are useful in the treatment or prevention of diseases, disorders or conditions that can be prevented and/or treated by iron chelation therapy, and/or neuroprotection and/or neurorestoration, and/or apoptosis inhibition and/or MAO inhibition and/or cholinesterase inhibition and/or NMADR inhibition. The present invention encompasses compounds of the formulas I to VI.
摘要:
The invention is substituted quinoline intermediates useful in the synthesis of the herbicide 2-(4-isopropyl-4-methyl 5-oxo 2-imidazolidinyl)-5-methoxymethylnicotinic acid and a process for preparing the herbicide intermediate 3-methoxymethyl-7- or 8-hydroxyquinoline.
摘要:
Novel tris-(polyalkoxyalkylated) isocyanurate compounds are described having the formula: ##STR1## wherein x is an integer from 2-10; Y is either a hydrogen or methyl group; and R is an alkyl group having from 1-4 carbon atoms. The use of these isocyanurate compounds as functional fluids, including hydraulic-type and heat transfer-type fluids, is also described. Such functional fluids have superior fire resistance properties.
摘要:
Novel compounds which upon heating are converted into the corresponding phenol which is a catalyst for the trimerization of compounds having isocyanato groups to form isocyanurates have the formula: ##SPC1##In whichn represents an integer of from 1 to 4A represents an aromatic hydrocarbon group obtained by removing the NCO group from a monomeric aromatic monoisocyanate containing 6 - 14 carbon atoms,R.sub.1 and R.sub.2 may be the same or different and represent a C.sub.1 to C.sub.6 alkyl group or a polymethylene chain containing 4 to 8 carbon atoms which together with a nitrogen atom form a heterocyclic ring,R.sub.3 may be hydrogen, chlorine, bromine or a C.sub.1 - C.sub.18 -alkyl group.
摘要:
Disclosure is provided for carbamate compounds that prevent, remove and/or inhibit the formation of biofilms, compositions including these compounds, devices including these compounds, and methods of using the same.
摘要:
Aryl- and heteroaryl-substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed.
WHEREIN R1 is hydrogen, C1-C4 alkyl, C3-C5 alkenyl or C3-C5 alkinyl, R2 is hydrogen, C1-C4 alkyl or optionally substituted C1-C6 acyl, R3 is hydrogen, C1-C6 alkyl optionally substituted by C1-C4 alkoxy groups or cyano, C3-C5 alkenyl or C3-C5 alkinyl, R4 and R5 are each hydrogen or C1-C4 alkyl, R6 and R7 are each hydrogen or C1-C4 alkyl or together are a further bond between the C atoms to which they are attached in the heterocyclic ring, and R8 is hydrogen, C1-C4 alkyl or halogen, The compound being in the form of the free base or of an acid addition salt thereof, processes for their manufacture and use as agents for pest control.