发明申请
- 专利标题： ANTI-VEGF ANTIBODIES
- 专利标题（中）： 抗VEGF抗体
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申请号： US12021232申请日： 2008-01-28
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公开(公告)号： US20080187534A1公开(公告)日： 2008-08-07
- 发明人: Manuel Baca , James A. Wells , Leonard G. Presta , Henry B. Lowman , Yvonne Man-Yee Chen
- 申请人： Manuel Baca , James A. Wells , Leonard G. Presta , Henry B. Lowman , Yvonne Man-Yee Chen
- 申请人地址： US CA South San Francisco
- 专利权人： Genentech, Inc.
- 当前专利权人： Genentech, Inc.
- 当前专利权人地址： US CA South San Francisco
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; C07K16/00 ; C07H21/04 ; C12N15/00 ; C12N5/00 ; C12P21/04
摘要：
Humanized and variant anti-VEGF antibodies and various uses therefor are disclosed. The anti-VEGF antibodies have strong binding affinities for VEGF; inhibit VEGF-induced proliferation of endothelial cells in vitro; and inhibit tumor growth in vivo.
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