发明申请
US20090054397A1 PYRAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUND
审中-公开
吡唑化合物和包含该化合物的药物组合物
- 专利标题: PYRAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUND
- 专利标题(中): 吡唑化合物和包含该化合物的药物组合物
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申请号: US12111918申请日: 2008-04-29
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公开(公告)号: US20090054397A1公开(公告)日: 2009-02-26
- 发明人: Norihito Ohi , Nobuaki Sato , Motohiro Soejima , Takashi Doko , Taro Terauchi , Yoshimitsu Naoe , Takafumi Motoki
- 申请人: Norihito Ohi , Nobuaki Sato , Motohiro Soejima , Takashi Doko , Taro Terauchi , Yoshimitsu Naoe , Takafumi Motoki
- 优先权: JP2002-158467 20020531; JP2003-153 20030106
- 主分类号: A61K31/397
- IPC分类号: A61K31/397 ; C07D471/02 ; A61K31/437 ; C07D231/56 ; A61K31/416 ; C07D401/02 ; A61K31/4439 ; C07D249/08 ; A61K31/4245 ; A61P25/00 ; A61K31/5377 ; C07D413/02 ; A61K31/497 ; A61K31/4184 ; A61K31/506 ; C07D271/10 ; A61K31/4196 ; C07D401/14 ; C07D241/36 ; A61K31/4985 ; C07D231/54 ; A61K31/4162
摘要:
The present invention provides a novel compound having an excellent JNK inhibitory effect. That is, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. Wherein R1 designates —(CO)h—(NRa)j—(CRb═CRc)k—Ar (wherein Ra, Rb and Rc each independently designate a hydrogen atom, a halogen atom, hydroxyl group, an optionally substituted C1-6 alkyl group or the like; Cy designates a 5- or 6-membered heteroaryl; and V each independently designate the formula -L-X—Y (wherein L designates a single bond, an optionally substituted C1-6 alkylene group or the like; X designates a single bond or the formula -A- (wherein A designates NR2, O, CO, S, SO or SO2) and so on; and Y designates a hydrogen atom, a halogen atom, nitro group or the like).
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