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19 条记录 (耗时 0.043 秒)

    1H-indazole compounds
    6.
    发明授权
    1H-indazole compounds 失效
    1H-吲唑化合物

    公开(公告)号：US07541376B2

    公开(公告)日：2009-06-02

    申请号：US11202234

    申请日：2005-08-12

    申请人： Hitoshi Oinuma ,  Norihito Ohi ,  Nobuaki Sato ,  Motohiro Soejima ,  Hidenori Seshimo ,  Taro Terauchi ,  Takashi Doko ,  Naohiro Kohmura

    发明人： Hitoshi Oinuma ,  Norihito Ohi ,  Nobuaki Sato ,  Motohiro Soejima ,  Hidenori Seshimo ,  Taro Terauchi ,  Takashi Doko ,  Naohiro Kohmura

    IPC分类号： A61K31/40 ,  C07D231/56

    CPC分类号： C07D231/56

    摘要： The present invention provides a novel 1H-indazole compound having an excellent JNK inhibitory action. More specifically, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. Wherein R1 is a C6-C14 aromatic cyclic hydrocarbon group etc.; R2, R4 and R5 each independently represent a hydrogen atom, a halogen atom, a cyano group etc.; L is a single bond, or a C1-C6 alkylene group etc.; X is a single bond, or a group represented by —CO—NH— or —NH—CO—, etc.; and Y is a C3-C8 cycloalkyl group, a C6-C14 aromatic cyclic hydrocarbon group or a 5- to 14-membered aromatic heterocyclic group etc.

    摘要翻译： 本发明提供了具有优异JNK抑制作用的新颖的1H-吲唑化合物。 更具体地，它提供由下式表示的化合物，其盐或它们的水合物。 其中R1是C6-C14芳族环烃基等; R2，R4和R5各自独立地表示氢原子，卤素原子，氰基等; L是单键或C1-C6亚烷基等; X是单键，或由-CO-NH-或-NH-CO-等表示的基团; Y为C3-C8环烷基，C6-C14芳族环状烃基或5〜14元芳香族杂环基等。

    1H-indazole compounds
    7.
    发明授权
    1H-indazole compounds 失效
    1H-吲唑化合物

    公开(公告)号：US07776890B2

    公开(公告)日：2010-08-17

    申请号：US12426818

    申请日：2009-04-20

    申请人： Hitoshi Oinuma ,  Norihito Ohi ,  Nobuaki Sato ,  Motohiro Soejima ,  Hidenori Seshimo ,  Taro Terauchi ,  Takashi Doko ,  Naohiro Kohmura

    发明人： Hitoshi Oinuma ,  Norihito Ohi ,  Nobuaki Sato ,  Motohiro Soejima ,  Hidenori Seshimo ,  Taro Terauchi ,  Takashi Doko ,  Naohiro Kohmura

    IPC分类号： A61K31/44 ,  C07D23/56

    CPC分类号： C07D231/56

    摘要： The present invention provides a novel 1H-indazole compound having an excellent JNK inhibitory action. More specifically, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. Wherein R1 is a C6-C14 aromatic cyclic hydrocarbon group etc.; R2, R4 and R5 each independently represent a hydrogen atom, a halogen atom, a cyano group etc.; L is a single bond, or a C1-C6 alkylene group etc.; X is a single bond, or a group represented by —CO—NH— or —NH—CO—, etc.; and Y is a C3-C8 cycloalkyl group, a C6-C14 aromatic cyclic hydrocarbon group or a 5- to 14-membered aromatic heterocyclic group etc.

    摘要翻译： 本发明提供了具有优异JNK抑制作用的新颖的1H-吲唑化合物。 更具体地，它提供由下式表示的化合物，其盐或它们的水合物。 其中R1是C6-C14芳族环烃基等; R2，R4和R5各自独立地表示氢原子，卤素原子，氰基等; L是单键或C1-C6亚烷基等; X是单键，或由-CO-NH-或-NH-CO-等表示的基团; Y为C3-C8环烷基，C6-C14芳族环状烃基或5〜14元芳香族杂环基等。

    1H-indazole compound
    8.
    发明授权
    1H-indazole compound 失效
    1H-吲唑化合物

    公开(公告)号：US06982274B2

    公开(公告)日：2006-01-03

    申请号：US10469399

    申请日：2002-04-15

    申请人： Hitoshi Oinuma ,  Norihito Ohi ,  Nobuaki Sato ,  Motohiro Soejima ,  Hidenori Seshimo ,  Taro Terauchi ,  Takashi Doko ,  Naohiro Kohmura

    发明人： Hitoshi Oinuma ,  Norihito Ohi ,  Nobuaki Sato ,  Motohiro Soejima ,  Hidenori Seshimo ,  Taro Terauchi ,  Takashi Doko ,  Naohiro Kohmura

    IPC分类号： A61K31/44 ,  C07D23/56 ,  A61P25/00

    CPC分类号： C07D231/56

    摘要： The present invention provides a novel 1H-indazole compound having an excellent JNK inhibitory action. More specifically, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. Wherein R1 is a C6-C14 aromatic cyclic hydrocarbon group etc.; R2, R4 and R5 each independently represent a hydrogen atom, a halogen atom, a cyano group etc.; L is a single bond, or a C1-C6 alkylene group etc.; X is a single bond, or a group represented by —CO—NH— or —NH—CO—, etc.; and Y is a C3-C8 cycloalkyl group, a C6-C14 aromatic cyclic hydrocarbon group or a 5- to 14-membered aromatic heterocyclic group etc.

    摘要翻译： 本发明提供了具有优异JNK抑制作用的新颖的1H-吲唑化合物。 更具体地，它提供由下式表示的化合物，其盐或它们的水合物。 其中R 1是C 6 -C 14芳族环状烃基等; R 2，R 4和R 5各自独立地表示氢原子，卤素原子，氰基等; L是单键或C 1 -C 6亚烷基等; X是单键，或由-CO-NH-或-NH-CO-等表示的基团; 和Y是C 3 -C 8环烷基，C 6 -C 14芳族环状烃基 或5〜14元芳香族杂环基等