发明申请
- 专利标题： AMINODIHYDROTHIAZINE DERIVATIVES
- 专利标题（中）： 氨基酸衍生物
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申请号： US12089409申请日： 2006-10-23
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公开(公告)号： US20090082560A1公开(公告)日： 2009-03-26
- 发明人: Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
- 申请人： Naotake Kobayashi , Kazuo Ueda , Naohiro Itoh , Shinji Suzuki , Gaku Sakaguchi , Akira Kato , Akira Yukimasa , Akihiro Hori , Yuji Koriyama , Hidekazu Haraguchi , Ken Yasui , Yasuhiko Kanda
- 申请人地址： JP Osaka-shi, Osaka
- 专利权人： Shionogi & Co., Ltd.
- 当前专利权人： Shionogi & Co., Ltd.
- 当前专利权人地址： JP Osaka-shi, Osaka
- 优先权： JP2005-309642 20051025; JP2006-076636 20060320
- 国际申请： PCT/JP2006/321015 WO 20061023
- 主分类号： C07D267/06
- IPC分类号： C07D267/06 ; C07D417/12 ; C07D279/06 ; C07D277/18
摘要：
A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.
公开/授权文献
- US08173642B2 Aminodihydrothiazine derivatives 公开/授权日：2012-05-08
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