摘要:
A composition having BACE 1 inhibitory activity containing a compound represented by the formula (I): wherein ring A is an optionally substituted heterocyclic group; E is lower alkylene; X is S; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; or its pharmaceutically acceptable salt thereof.
摘要:
A method for the manufacture of an adhesive suitable for use with polyvinylfluoride sheets which includes the steps of copolymerizing a vinyl compound and a vinyl compound having an epoxy group and then treating the copolymer thus produced with aqueous ammonia to aminate the epoxy group.
摘要:
A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.
摘要:
A process for the production of 4-thiazolylmethyl derivatives are provided. A process for the production of the compound represented by the formula (I): wherein R1 is hydrogen or halogen and Hal is halogen, which comprises reacting 4-methylthiazole with N-halosuccinimide in a solvent in the presence of a radical initiator.
摘要:
The present invention relates to a cover film for hard copy printing paper which can easily form a colorless and transparent protecting layer on the surface of, for example, a printing paper on which a color picture image is printed. The cover film for hard copy printing paper is such one that the cover film for hard copy printing paper is formed on the surface of a hard copy printing paper on which the printing is carried out by the sublimation transfer method and the cover film is designed to include at least one layer the glass transition temperature of which is selected to be higher than 40.degree. C. and whose water absorbing ratio (ASTM D570) is selected to be lower than 2%, whereby even under high temperature and high humidity, the bad influence exerted by the movement of a dye can be removed.
摘要:
An electrically conductive adhesive sheet is disclosed which has an electrically conducting property across a thickness thereof and an electrically insulating property along a sheet surface direction. The electrically conductive adhesive sheet comprises an electrically insulating adhesive material and electrically conductive metal powder uniformly dispersed therein. The metal powder has a melting point lower than a certain working temperature, and is flattened by application of pressure between a pair of conductors between which the adhesive sheet is provided. The adhesive material is molten at the certain working temperature and is flown by application of pressure. The adhesive sheet is useful to electrically connect a pair of circuit boards each having a plurality of conductor patterns thereon by bonding corresponding ones through the metal powder as molten, while keeping the neighboring patterns insulated. The circuit board is mechanically integrated simultaneously by the adhesive sheet. The circuit board and the connection structure using such an adhesive sheet as above are also disclosed.
摘要:
A cover film for a sublimation transfer type hard copy of the present invention is a cover film which is melt bonded by heat on the surface of a hard copy printing paper in which a picture image is formed on the surface thereof by selectively transferring a sublimation dye. The cover film includes a resinous layer containing a metal compound selected from Al, Mg, Ca and Sn. This cover film is capable of producing magenta color of high color saturation by arbitrarily controlling the coloring of reddish dye to be shifted to the blue side and can also protect the surface of the printing paper.Furthermore, the present invention relates to a cover film which is melt bonded by heat on the surface of a hard copy printing paper in which a picture image is formed on the surface thereof by selectively transferring a sublimation dye. This cover film includes a layer mainly formed of a phosphor whitener and a resin to increase a whiteness degree of a portion which is not colored so that a picture image is made clear and which can prevent the color of dye from being faded.
摘要:
A pharmaceutical composition for treating Alzheimer's disease containing a compound represented by the general formula (I); wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene, etc.; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b are each independently a hydrogen atom, halogen, hydroxy, etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 1 to 3; and R5 is a hydrogen atom, optionally substituted lower alkyl, etc.; its pharmaceutically acceptable salt, or a solvate thereof as an active ingredient.
摘要:
A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR1; R1 is a hydrogen atom or lower alkyl; R2a, R2b, R3a, R3b, R4a and R4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.
摘要:
The present invention relates to an ink ribbon for sublimation transfer type hard copy which is used to produce as a hard copy a still picture image such as a picture image taken by a video camera, a television picture image and so on. The ink ribbon for sublimation transfer type hard copy of this invention comprises a heat-resistant plastic film base or a plastic film base having formed thereon a heat-resistant treating layer and coating layer of sublimation dye formed on the plastic film base. According to this ink ribbon for sublimation transfer type hard copy, it is possible to protect the film base from being shrunk and producing a bubble spot therein due to heat generated upon transfer, etc. Accordingly, a quality of a transferred picture image can be improved.