发明申请
- 专利标题： Interleukin-15 Antagonist Peptide
- 专利标题（中）： 白介素15拮抗肽
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申请号： US11662844申请日： 2005-09-16
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公开(公告)号： US20090136511A1公开(公告)日： 2009-05-28
- 发明人: Alicia Santos Savio , Ania Cabrales Rico , Osvaldo Reyes Acosta , Haydee Geronimo Perez , Celia Aurora Arrieta Aguero , Silvio Ernesto Perea Rodriguez
- 申请人： Alicia Santos Savio , Ania Cabrales Rico , Osvaldo Reyes Acosta , Haydee Geronimo Perez , Celia Aurora Arrieta Aguero , Silvio Ernesto Perea Rodriguez
- 申请人地址： CU Ciudad de La Habana
- 专利权人： CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA
- 当前专利权人： CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA
- 当前专利权人地址： CU Ciudad de La Habana
- 优先权： CU2004-0198 20040917
- 国际申请： PCT/CU05/00007 WO 20050916
- 主分类号： A61K38/08
- IPC分类号： A61K38/08 ; C07K7/06 ; A61K39/00 ; A61K39/395 ; A61P19/02 ; A61P17/06 ; C07K16/00 ; C07H21/00
摘要：
Current invention is related to the molecular pharmacology branch particularly to a peptide belonging to the Interleukin-15 sequence (IL-15) which is able to inhibit IL-15 biological activity, analogues or mimetic of such peptides. In the current invention it is shown that the peptide inhibits both IL-15-induced T cells proliferation upon binding to the IL15 receptor α subunit (IL15Rα) and TNFα-mediated apoptosis.Besides, this invention is related to the use of this peptide in the treatment of several pathologies where aberrant IL-15 or IL-15Rα expression is associated to the disease progression.
公开/授权文献
- US07736638B2 Interleukin-15 antagonist peptide 公开/授权日：2010-06-15
信息查询
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