公开(公告)号：US20090136511A1

公开(公告)日：2009-05-28

申请号：US11662844

申请日：2005-09-16

申请人： Alicia Santos Savio ,  Ania Cabrales Rico ,  Osvaldo Reyes Acosta ,  Haydee Geronimo Perez ,  Celia Aurora Arrieta Aguero ,  Silvio Ernesto Perea Rodriguez

发明人： Alicia Santos Savio ,  Ania Cabrales Rico ,  Osvaldo Reyes Acosta ,  Haydee Geronimo Perez ,  Celia Aurora Arrieta Aguero ,  Silvio Ernesto Perea Rodriguez

IPC分类号： A61K38/08 ,  C07K7/06 ,  A61K39/00 ,  A61K39/395 ,  A61P19/02 ,  A61P17/06 ,  C07K16/00 ,  C07H21/00

CPC分类号： C07K14/5443 ,  A61K38/00 ,  A61K39/00 ,  C07K16/244

摘要： Current invention is related to the molecular pharmacology branch particularly to a peptide belonging to the Interleukin-15 sequence (IL-15) which is able to inhibit IL-15 biological activity, analogues or mimetic of such peptides. In the current invention it is shown that the peptide inhibits both IL-15-induced T cells proliferation upon binding to the IL15 receptor α subunit (IL15Rα) and TNFα-mediated apoptosis.Besides, this invention is related to the use of this peptide in the treatment of several pathologies where aberrant IL-15 or IL-15Rα expression is associated to the disease progression.

摘要翻译： 本发明涉及分子药理学分支，特别是涉及能够抑制IL-15生物活性，类似物或模拟这些肽的白细胞介素-15序列（IL-15）的肽。 在本发明中，显示该肽在结合IL15受体α亚基（IL15Rα）和TNFα介导的细胞凋亡时抑制IL-15诱导的T细胞增殖。 此外，本发明涉及该肽用于治疗其中异常IL-15或IL-15Rα表达与疾病进展相关的若干病理学的用途。

公开(公告)号：US07736638B2

公开(公告)日：2010-06-15

申请号：US11662844

申请日：2005-09-16

申请人： Alicia Santos Savio ,  Ania Cabrales Rico ,  Osvaldo Reyes Acosta ,  Haydee Geronimo Perez ,  Celia Aurora Arrieta Aguero ,  Silvio Ernesto Perea Rodriguez

发明人： Alicia Santos Savio ,  Ania Cabrales Rico ,  Osvaldo Reyes Acosta ,  Haydee Geronimo Perez ,  Celia Aurora Arrieta Aguero ,  Silvio Ernesto Perea Rodriguez

IPC分类号： A61K38/20 ,  C12N15/06 ,  C07K14/54 ,  C12N5/02 ,  C12P21/02

CPC分类号： C07K14/5443 ,  A61K38/00 ,  A61K39/00 ,  C07K16/244

摘要： Current invention is related to the molecular pharmacology branch particularly to a peptide belonging to the Interleukin-15 sequence (IL-15) which is able to inhibit IL-15 biological activity, analogues or mimetic of such peptides. In the current invention it is shown that the peptide inhibits both IL-15-induced T cells proliferation upon binding to the IL15 receptor a subunit (IL15Rα) and TNFα-mediated apoptosis.Besides, this invention is related to the use of this peptide in the treatment of several pathologies where aberrant IL-15 or IL-15Rα expression is associated to the disease progression.

摘要翻译： 本发明涉及分子药理学分支，特别是涉及能够抑制IL-15生物活性，类似物或模拟这些肽的白细胞介素-15序列（IL-15）的肽。 在本发明中，显示肽结合IL15受体a亚基（IL15Rα）和TNFα介导的细胞凋亡后，抑制IL-15诱导的T细胞增殖。 此外，本发明涉及该肽用于治疗其中异常IL-15或IL-15Rα表达与疾病进展相关的几种病症的用途。