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公开(公告)号：US20090136511A1
公开(公告)日：2009-05-28
申请号：US11662844
申请日：2005-09-16
申请人： Alicia Santos Savio , Ania Cabrales Rico , Osvaldo Reyes Acosta , Haydee Geronimo Perez , Celia Aurora Arrieta Aguero , Silvio Ernesto Perea Rodriguez
发明人： Alicia Santos Savio , Ania Cabrales Rico , Osvaldo Reyes Acosta , Haydee Geronimo Perez , Celia Aurora Arrieta Aguero , Silvio Ernesto Perea Rodriguez
IPC分类号： A61K38/08 , C07K7/06 , A61K39/00 , A61K39/395 , A61P19/02 , A61P17/06 , C07K16/00 , C07H21/00
CPC分类号： C07K14/5443 , A61K38/00 , A61K39/00 , C07K16/244
摘要： Current invention is related to the molecular pharmacology branch particularly to a peptide belonging to the Interleukin-15 sequence (IL-15) which is able to inhibit IL-15 biological activity, analogues or mimetic of such peptides. In the current invention it is shown that the peptide inhibits both IL-15-induced T cells proliferation upon binding to the IL15 receptor α subunit (IL15Rα) and TNFα-mediated apoptosis.Besides, this invention is related to the use of this peptide in the treatment of several pathologies where aberrant IL-15 or IL-15Rα expression is associated to the disease progression.
摘要翻译： 本发明涉及分子药理学分支，特别是涉及能够抑制IL-15生物活性，类似物或模拟这些肽的白细胞介素-15序列（IL-15）的肽。 在本发明中，显示该肽在结合IL15受体α亚基（IL15Rα）和TNFα介导的细胞凋亡时抑制IL-15诱导的T细胞增殖。 此外，本发明涉及该肽用于治疗其中异常IL-15或IL-15Rα表达与疾病进展相关的若干病理学的用途。
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公开(公告)号：US07736638B2
公开(公告)日：2010-06-15
申请号：US11662844
申请日：2005-09-16
申请人： Alicia Santos Savio , Ania Cabrales Rico , Osvaldo Reyes Acosta , Haydee Geronimo Perez , Celia Aurora Arrieta Aguero , Silvio Ernesto Perea Rodriguez
发明人： Alicia Santos Savio , Ania Cabrales Rico , Osvaldo Reyes Acosta , Haydee Geronimo Perez , Celia Aurora Arrieta Aguero , Silvio Ernesto Perea Rodriguez
CPC分类号： C07K14/5443 , A61K38/00 , A61K39/00 , C07K16/244
摘要： Current invention is related to the molecular pharmacology branch particularly to a peptide belonging to the Interleukin-15 sequence (IL-15) which is able to inhibit IL-15 biological activity, analogues or mimetic of such peptides. In the current invention it is shown that the peptide inhibits both IL-15-induced T cells proliferation upon binding to the IL15 receptor a subunit (IL15Rα) and TNFα-mediated apoptosis.Besides, this invention is related to the use of this peptide in the treatment of several pathologies where aberrant IL-15 or IL-15Rα expression is associated to the disease progression.
摘要翻译： 本发明涉及分子药理学分支，特别是涉及能够抑制IL-15生物活性，类似物或模拟这些肽的白细胞介素-15序列（IL-15）的肽。 在本发明中，显示肽结合IL15受体a亚基（IL15Rα）和TNFα介导的细胞凋亡后，抑制IL-15诱导的T细胞增殖。 此外，本发明涉及该肽用于治疗其中异常IL-15或IL-15Rα表达与疾病进展相关的几种病症的用途。
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公开(公告)号：US08420311B2
公开(公告)日：2013-04-16
申请号：US12298808
申请日：2007-04-26
申请人： Vivian Huerta Galindo , Glay Chinea Santiago , Noralvis Fleitas Salazar , Alejandro Miguel Martin Dunn , Monica Sarria Nunez , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Aniel Sanchez Puente , Vladimir Armando Besada Perez , Osvaldo Reyes Acosta , Hilda Elisa Garay Perez , Ania Cabrales Rico , Alexis Musacchio Lasa , Gabriel Ramon Padron Palomares , Luis Javier Gonzalez Lopez
发明人： Vivian Huerta Galindo , Glay Chinea Santiago , Noralvis Fleitas Salazar , Alejandro Miguel Martin Dunn , Monica Sarria Nunez , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Aniel Sanchez Puente , Vladimir Armando Besada Perez , Osvaldo Reyes Acosta , Hilda Elisa Garay Perez , Ania Cabrales Rico , Alexis Musacchio Lasa , Gabriel Ramon Padron Palomares , Luis Javier Gonzalez Lopez
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K14/70596 , C07K14/8107 , C12N2770/24122 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： The present invention is related to a method for blocking the infection of cells by dengue virus, based on interfering the direct interaction of the viral envelope protein with a cellular receptor or its indirect interaction with said cellular receptor through a carrier protein, as well as related uses; wherein said cellular receptor is the alpha-2 macroglobulin receptor, also known as the low density receptor-related protein or as CD91, and said carrier protein is human alpha-2 macroglobulin.
摘要翻译： 本发明涉及一种基于干扰病毒包膜蛋白与细胞受体的直接相互作用或其通过载体蛋白与所述细胞受体的间接相互作用而阻断登革热病毒感染细胞的方法，以及相关的 用途; 其中所述细胞受体是α-2巨球蛋白受体，也称为低密度受体相关蛋白或CD91，所述载体蛋白是人α-2巨球蛋白。
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4.发明申请CHIMERICAL PEPTIDIC MOLECULES WITH ANTIVIRAL PROPERTIES AGAINST THE VIRUSES OF THE FLAVIVIRIDAE FAMILY 有权具有抗FLAVIVIRIDIDE家族病毒抗性特性的二肽分子公开(公告)号：US20100273702A1
公开(公告)日：2010-10-28
申请号：US12513085
申请日：2007-10-30
申请人： Glay Chinea Santiago , Vivian Juerta Galindo , Alejandro Miguel Martin Dunn , Noralvis Fleitas Salazar , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Mónica Srria Nüñez , Alexis Musacchio Lasa , Osvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Ania Cabrales Rico
发明人： Glay Chinea Santiago , Vivian Juerta Galindo , Alejandro Miguel Martin Dunn , Noralvis Fleitas Salazar , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Mónica Srria Nüñez , Alexis Musacchio Lasa , Osvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Ania Cabrales Rico
CPC分类号： A61K47/48315 , A61K38/00 , A61K47/645 , C07K14/005 , C07K2319/04 , C07K2319/10 , C12N2770/24022 , C12N2770/24122 , C12N2770/24222 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： The present invention is relative to chimerical peptides, whose primary structure holds at least one segment which inhibits the activation of the NS3 protease of a virus from the Flaviviridae family, they also contain a cell penetrating segment and they are capable of inhibiting or attenuate the viral infection. This invention is also relative to pharmaceutical compounds which contain these chimerical peptides for the prevention and/or treatment of the infection caused by a virus of the Flaviviridae family.
摘要翻译： 本发明是相对于嵌合肽，其主要结构保持至少一个片段，其抑制来自黄病毒科的病毒的NS3蛋白酶的活化，它们还含有细胞穿透片段，并且它们能够抑制或减弱病毒 感染。 本发明还涉及含有这些嵌合肽用于预防和/或治疗由黄病毒科病毒引起的感染的药物化合物。
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5.发明申请公开(公告)号：US20110212105A1
公开(公告)日：2011-09-01
申请号：US12298808
申请日：2007-04-26
申请人： Vivian Huerta Galindo , Glay Chinea Santiago , Noralvis Fleitas Salazar , Alejandro Miguel Martín Dunn , Mónica Sarría Núñez , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Aniel Sánchez Puente , Vladimir Armando Besada Pérez , Osvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Ania Cabrales Rico , Alexis Musacchio Lasa , Gabriel Ramón Padrón Palomares , Luis Javier González López
发明人： Vivian Huerta Galindo , Glay Chinea Santiago , Noralvis Fleitas Salazar , Alejandro Miguel Martín Dunn , Mónica Sarría Núñez , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Aniel Sánchez Puente , Vladimir Armando Besada Pérez , Osvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Ania Cabrales Rico , Alexis Musacchio Lasa , Gabriel Ramón Padrón Palomares , Luis Javier González López
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K14/70596 , C07K14/8107 , C12N2770/24122 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： The present invention is related to a method for blocking the infection of cells by dengue virus, based on interfering the direct interaction of the viral envelope protein with a cellular receptor or its indirect interaction with said cellular receptor through a carrier protein, as well as related uses; wherein said cellular receptor is the alpha-2 macroglobulin receptor, also known as the low density receptor-related protein or as CD91, and said carrier protein is human alpha-2 macroglobulin.
摘要翻译： 本发明涉及一种基于干扰病毒包膜蛋白与细胞受体的直接相互作用或其通过载体蛋白与所述细胞受体的间接相互作用而阻断登革热病毒感染细胞的方法，以及相关的 用途; 其中所述细胞受体是α-2巨球蛋白受体，也称为低密度受体相关蛋白或CD91，所述载体蛋白是人α-2巨球蛋白。
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