Invention Application
US20120077270A1 Control of Gene Expression Using a Complex of an Oligonucleotide and a Regulatory Peptide
审中-公开
使用寡核苷酸和调节肽的复合物控制基因表达
- Patent Title: Control of Gene Expression Using a Complex of an Oligonucleotide and a Regulatory Peptide
- Patent Title (中): 使用寡核苷酸和调节肽的复合物控制基因表达
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Application No.: US13251627Application Date: 2011-10-03
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Publication No.: US20120077270A1Publication Date: 2012-03-29
- Inventor: Stephen Hart , Simak Ali , Boris Tumi PuFong , Andrew C.G. Porter , Laki Buluwela , Satu Vainikka , John David Jenkinson , Patrick Kanda
- Applicant: Stephen Hart , Simak Ali , Boris Tumi PuFong , Andrew C.G. Porter , Laki Buluwela , Satu Vainikka , John David Jenkinson , Patrick Kanda
- Applicant Address: GB London
- Assignee: IMPERIAL COLLEGE INNOVATIONS LIMITED
- Current Assignee: IMPERIAL COLLEGE INNOVATIONS LIMITED
- Current Assignee Address: GB London
- Priority: GB0124391.4 20011011
- Main IPC: C12N5/071
- IPC: C12N5/071 ; C07K1/00 ; C07K14/00 ; C12N5/04 ; C12N1/20
Abstract:
A method for suppressing the expression of a selected gene in a cell, the method comprising introducing into the cell a molecule comprising (1) a nucleic acid binding portion which binds to a site or associated with the selected gene which site is present in a genome and (2) an expression repressor portion, wherein the nucleic acid binding portion comprises an oligonucleotide or oligonucleotide mimic or analogue, and wherein the repressor portion comprises a polypeptide or peptidomimetic. Molecules for use in the methods of the invention are provided. The repressor may be a portion of a histone deacetylase or DNA methylase or polypeptide capable of recruiting a histone deacetylase or DNA methylase.
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