Invention Application
US20150165063A1 1-(CHLOROMETHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE DIMER ANTIBODY-DRUG CONJUGATE COMPOUNDS, AND METHODS OF USE AND TREATMENT
审中-公开
1-（氯代乙基）-2,3-二氢-1H-苯并[E]吲哚类抗生素联合化合物，以及使用和治疗方法
![1-(CHLOROMETHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE DIMER ANTIBODY-DRUG CONJUGATE COMPOUNDS, AND METHODS OF USE AND TREATMENT](/docs/US/2015-06-18/US20150165063A1/abs.jpg.600x600.jpg)
- Patent Title: 1-(CHLOROMETHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE DIMER ANTIBODY-DRUG CONJUGATE COMPOUNDS, AND METHODS OF USE AND TREATMENT
- Patent Title (中): 1-（氯代乙基）-2,3-二氢-1H-苯并[E]吲哚类抗生素联合化合物，以及使用和治疗方法
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Application No.: US14305643Application Date: 2014-06-16
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Publication No.: US20150165063A1Publication Date: 2015-06-18
- Inventor: John Flygare , Thomas Pillow , Brian Safina , Vishal Verma , Binqing Wei , William Denny , Anna Giddens , Ho Lee , Guo-Liang Lu , Christian Miller , Gordon Rewcastle , Moana Tercel , Muriel Bonnet
- Applicant: Genentech, Inc.
- Main IPC: A61K47/48
- IPC: A61K47/48 ; C07K16/18 ; C07K16/32 ; C07D401/14 ; C07K5/062 ; C07F9/6558 ; C07D403/14 ; C07H15/24 ; C07K16/28 ; C07D209/62
![1-(CHLOROMETHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE DIMER ANTIBODY-DRUG CONJUGATE COMPOUNDS, AND METHODS OF USE AND TREATMENT](/abs-image/US/2015/06/18/US20150165063A1/abs.jpg.150x150.jpg)
Abstract:
The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.
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