Invention Grant
![1-(chloromethyl)-2,3-dihydro-1H-benzo[E]indole dimer antibody-drug conjugate compounds, and methods of use and treatment](/docs/US/2019-10-15/US10442836B2/abs.jpg.600x600.jpg)
- Patent Title: 1-(chloromethyl)-2,3-dihydro-1H-benzo[E]indole dimer antibody-drug conjugate compounds, and methods of use and treatment
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Application No.: US14305643Application Date: 2014-06-16
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Publication No.: US10442836B2Publication Date: 2019-10-15
- Inventor: John Flygare , Thomas Pillow , Brian Safina , Vishal Verma , Binqing Wei , William Denny , Anna Giddens , Ho Lee , Guo-Liang Lu , Christian Miller , Gordon Rewcastle , Moana Tercel , Muriel Bonnet
- Applicant: Genentech, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Viksnins Harris Padys Malen LLP
- Main IPC: A61K47/68
- IPC: A61K47/68 ; C07K16/28 ; C07D207/40 ; C07D209/60 ; C07K5/062 ; C07D487/04 ; C07D209/62 ; C07D401/14 ; C07D403/14 ; C07F9/6558 ; C07H15/24 ; C07K16/32 ; C07D401/12 ; C07D471/04 ; C07K16/00 ; C07K16/30 ; A61K47/55 ; C07F9/572 ; C07F9/6561
![1-(chloromethyl)-2,3-dihydro-1H-benzo[E]indole dimer antibody-drug conjugate compounds, and methods of use and treatment](/abs-image/US/2019/10/15/US10442836B2/abs.jpg.150x150.jpg)
Abstract:
The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.
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