发明申请
- 专利标题: BENZIMIDAZOLONE DERIVATIVES AS BROMODOMAIN INHIBITORS
- 专利标题(中): 苯并咪唑衍生物作为BROMODOMAIN抑制剂
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申请号: US14774019申请日: 2014-03-27
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公开(公告)号: US20160031868A1公开(公告)日: 2016-02-04
- 发明人: Evangelos Aktoudianakis , Gregory Chin , Britton Kenneth Corkey , Jinfa Du , Kristyna Elbel , Robert H. Jiang , Tetsuya Kobayashi , Ruben Martinez , Samuel E. Metobo , Michael Mish , Sophie Shevick , David Sperandio , Hai Yang , Jeff Zablocki
- 申请人: GILEAD SCIENCES, INC.
- 国际申请: PCT/US2014/032031 WO 20140327
- 主分类号: C07D413/14
- IPC分类号: C07D413/14
摘要:
This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2a, R2b, R3, and X are described herein.
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