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公开(公告)号：US11642361B2
公开(公告)日：2023-05-09
申请号：US17077267
申请日：2020-10-22
Applicant: Gilead Sciences, Inc.
Inventor： Jinfa Du , Dhanapalan Nagarathnam , Michael Joseph Sofia , Peiyuan Wang
IPC: A61K31/7076 , A61K31/7072 , A61K31/706 , A61K31/7064 , C07H19/04 , C07H19/20 , C07H19/06 , C07H19/10 , A61K45/06 , C07H17/02 , C07D417/14 , A61K31/7068 , C07H19/073
CPC classification number: A61K31/7072 , A61K31/706 , A61K31/7064 , A61K31/7076 , A61K45/06 , C07D417/14 , C07H17/02 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/20 , A61K31/7068 , C07H19/073 , Y02A50/30
Abstract: Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure:
Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.-
公开(公告)号：US20160031868A1
公开(公告)日：2016-02-04
申请号：US14774019
申请日：2014-03-27
Applicant: GILEAD SCIENCES, INC.
Inventor： Evangelos Aktoudianakis , Gregory Chin , Britton Kenneth Corkey , Jinfa Du , Kristyna Elbel , Robert H. Jiang , Tetsuya Kobayashi , Ruben Martinez , Samuel E. Metobo , Michael Mish , Sophie Shevick , David Sperandio , Hai Yang , Jeff Zablocki
IPC: C07D413/14
CPC classification number: C07D413/14 , C07D413/04 , C07D417/14
Abstract: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2a, R2b, R3, and X are described herein.
Abstract translation: 本申请涉及可用作含溴结构域的蛋白质（包括含溴结构域蛋白质的蛋白质4（BRD4））的抑制剂或其它方式调节其含有活性的蛋白质的化学化合物，以及含有这些化合物的组合物和制剂，以及 使用和制造这些化合物。 化合物包括其中R1a，R1b，R2a，R2b，R3和X在本文中描述的式（I）的化合物。
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公开(公告)号：US12161625B2
公开(公告)日：2024-12-10
申请号：US18059806
申请日：2022-11-29
Applicant: Gilead Sciences, Inc.
Inventor： Jinfa Du , Joshua A. Kaplan , Thorsten A. Kirschberg , Tetsuya Kobayashi , Scott E. Lazerwith , Rick Andrew Lee , Jonathan William Medley , Michael L. Mitchell , Philip Anthony Morganelli , Hyung-Jung Pyun , Sophia L. Shevick , Neil H. Squires , William J. Watkins
IPC: A61K31/403 , A61K31/03 , A61K31/16 , A61K31/38 , A61K31/4192 , A61P31/20 , C07D487/04 , C07D519/00
Abstract: This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.
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公开(公告)号：US20160376261A1
公开(公告)日：2016-12-29
申请号：US15239422
申请日：2016-08-17
Applicant: Gilead Sciences, Inc.
Inventor： Evangelos Aktoudianakis , Gregory Chin , Britton Kenneth Corkey , Jinfa Du , Kristyna Elbel , Robert H. Jiang , Tetsuya Kobayashi , Rick Lee , Ruben Martinez , Samuel E. Metobo , Michael Mish , Manuel Munoz , Sophie Shevick , David Sperandio , Hai Yang , Jeff Zablocki
IPC: C07D413/04 , C07D453/02 , C07D417/14 , C07D413/14 , C07D471/04
CPC classification number: C07D413/04 , C07D413/14 , C07D417/14 , C07D453/02 , C07D471/04
Abstract: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2a, R2b, R3, R4a, R4b, and R5 are described herein.
Abstract translation: 其中R1a，R1b，R2a，R2b，R3，R4a，R4b和R5如本文所述。
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公开(公告)号：US20140336190A1
公开(公告)日：2014-11-13
申请号：US14273147
申请日：2014-05-08
Applicant: Gilead Sciences, Inc.
Inventor： Evangelos Aktoudianakis , Gregory Chin , Britton Kenneth Corkey , Jinfa Du , Kristyna Elbel , Robert H. Jiang , Tetsuya Kobayashi , Rick Lee , Ruben Martinez , Samuel E. Metobo , Michael Mish , Manuel Munoz , Sophie Shevick , David Sperandio , Hai Yang , Jeff Zablocki
IPC: C07D471/04 , C07D413/14 , C07D417/14 , C07D413/04
CPC classification number: C07D413/04 , C07D413/14 , C07D417/14 , C07D453/02 , C07D471/04
Abstract: This application relates to chemical compounds which may act as inhibitors of; or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2, R2b, R3, R4a, R4b, and R5 are described herein.
Abstract translation: 本申请涉及可用作抑制剂的化合物; 或其它可能调节含溴结构域的蛋白质（包括含有溴结构域的蛋白质4（BRD4））的活性，以及含有这些化合物的组合物和制剂，以及使用和制备这些化合物的方法。 化合物包括其中R1a，R1b，R2，R2b，R3，R4a，R4b和R5如本文所述的式（I）化合物。
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Patent Agency Ranking
公开(公告)号：US12121529B2
公开(公告)日：2024-10-22
申请号：US18511973
申请日：2023-11-16
Applicant: Gilead Sciences, Inc.
Inventor： Jinfa Du , Dhanapalan Nagarathnam , Michael Joseph Sofia , Peiyuan Wang
IPC: A61K31/7072 , A61K31/706 , A61K31/7064 , A61K31/7076 , A61K45/06 , C07D417/14 , C07H17/02 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/20 , A61K31/7068 , C07H19/073
CPC classification number: A61K31/7072 , A61K31/706 , A61K31/7064 , A61K31/7076 , A61K45/06 , C07D417/14 , C07H17/02 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/20 , A61K31/7068 , C07H19/073 , Y02A50/30
Abstract: Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure:
Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.-
公开(公告)号：US20200061024A1
公开(公告)日：2020-02-27
申请号：US16403247
申请日：2019-05-03
Applicant: GILEAD SCIENCES, INC.
Inventor： Jinfa Du , Joshua A. Kaplan , Thorsten A. Kirschberg , Tetsuya Kobayashi , Scott E. Lazerwith , Rick Andrew Lee , Jonathan William Medley , Michael L. Mitchell , Philip Anthony Morganelli , Hyung-Jung Pyun , Sophia L. Shevick , Neil H. Squires , William J. Watkins
IPC: A61K31/403 , A61K31/4192 , A61K31/38 , A61K31/16 , A61K31/03 , A61P31/20 , C07D519/00 , C07D487/04
Abstract: This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.
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公开(公告)号：US20180282316A1
公开(公告)日：2018-10-04
申请号：US16001832
申请日：2018-06-06
Applicant: Gilead Sciences, Inc.
Inventor： Evangelos Aktoudianakis , Gregory Chin , Britton Kenneth Corkey , Jinfa Du , Kristyna M. Elbel , Robert H. Jiang , Tetsuya Kobayashi , Rick Andrew Lee , Ruben Martinez , Samuel E. Metobo , Michael R. Mish , Manuel Munoz , Sophia L. Shevick , David Sperandio , Hai Yang , Jeff Zablocki
IPC: C07D413/04 , C07D453/02 , C07D417/14 , C07D471/04 , C07D413/14
Abstract: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2a, R2b, R3, R4a, R4b, and R5 are described herein.
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公开(公告)号：US09458145B2
公开(公告)日：2016-10-04
申请号：US14273147
申请日：2014-05-08
Applicant: Gilead Sciences, Inc.
Inventor： Evangelos Aktoudianakis , Gregory Chin , Britton Kenneth Corkey , Jinfa Du , Kristyna Elbel , Robert H. Jiang , Tetsuya Kobayashi , Rick Lee , Ruben Martinez , Samuel E. Metobo , Michael Mish , Manuel Munoz , Sophie Shevick , David Sperandio , Hai Yang , Jeff Zablocki
IPC: C07D471/04 , C07D417/14 , C07D413/14 , C07D413/04
CPC classification number: C07D413/04 , C07D413/14 , C07D417/14 , C07D453/02 , C07D471/04
Abstract: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2a, R2b, R3, R4a, R4b, and R5 are described herein.
Abstract translation: 本申请涉及可用作抑制剂的化合物; 或其它可能调节含溴结构域的蛋白质（包括含有溴结构域的蛋白质4（BRD4））的活性，以及含有这些化合物的组合物和制剂，以及使用和制备这些化合物的方法。 化合物包括其中R1a，R1b，R2，R2b，R3，R4a，R4b和R5如本文所述的式（I）化合物。
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公开(公告)号：US09255089B2
公开(公告)日：2016-02-09
申请号：US14227736
申请日：2014-03-27
Applicant: Gilead Sciences, Inc.
Inventor： Evangelos Aktoudianakis , Gregory Chin , Britton Kenneth Corkey , Jinfa Du , Kristyna Elbel , Robert H. Jiang , Tetsuya Kobayashi , Ruben Martinez , Samuel E. Metobo , Michael R. Mish , Sophie Shevick , David Sperandio , Hai Yang , Jeff Zablocki
IPC: C07D413/14 , C07D413/04 , C07D417/14
CPC classification number: C07D413/14 , C07D413/04 , C07D417/14
Abstract: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2a, R2b, R3, and X are described herein.
Abstract translation: 本申请涉及可用作含溴结构域的蛋白质（包括含溴结构域蛋白质的蛋白质4（BRD4））的抑制剂或其它方式调节其含有活性的蛋白质的化学化合物，以及含有这些化合物的组合物和制剂，以及 使用和制造这些化合物。 化合物包括其中R1a，R1b，R2a，R2b，R3和X在本文中描述的式（I）的化合物。
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