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公开(公告)号:US20230039553A1
公开(公告)日:2023-02-09
申请号:US17243911
申请日:2021-04-29
发明人: Mark J. Bartlett , Gregory F. Chin , Michael O. Clarke , Jennifer L. Cosman , Deeba Ensan , Bindu Goyal , Stephen Ho , Hon C. Hui , Richard L. Mackman , Michael R. Mish , Scott D. Schroeder , Nathan D. Shapiro , Dustin S. Siegel , Doris T. Tang , Hai Yang
IPC分类号: C07D487/04 , C07D519/00 , A61K45/06 , C07K16/28
摘要: The present disclosure provides pyrimidine dione compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors. The compounds can be used alone or in combination with other anti-cancer agents.
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公开(公告)号:US20210284670A1
公开(公告)日:2021-09-16
申请号:US17178463
申请日:2021-02-18
发明人: Gregory F. Chin , Byoung-Kwon Chun , Michael O. Clarke , Bindu Goyal , Hon C. Hui , Petr Jansa , Richard L. Mackman , Dustin S. Siegel , Hai Yang
IPC分类号: C07F9/6561 , A61P31/14
摘要: The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, Ebola, Zika, West Nile, Dengue, and HCV.
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公开(公告)号:US20180298011A1
公开(公告)日:2018-10-18
申请号:US15923726
申请日:2018-03-16
发明人: Kerim Babaoglu , Constantine G. Boojamra , Eugene J. Eisenberg , Hon Chung Hui , Richard L. Mackman , Jay P. Parrish , Michael Sangi , Oliver L. Saunders , Dustin Siegel , David Sperandio , Hai Yang
IPC分类号: C07D487/04 , A61K45/06 , C07F9/6561 , C07D519/00 , A61K31/519 , C07D495/04 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/675 , C07D513/04
摘要: The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.
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公开(公告)号:US09951065B2
公开(公告)日:2018-04-24
申请号:US15153527
申请日:2016-05-12
发明人: Mark J. Bartlett , Julian Andrew Codelli , Britton Kenneth Corkey , Jennifer Leigh Cosman , Kristyna Elbel , Jennifer Alissa Loyer-Drew , David Sperandio , Joshua Van Veldhuizen , Hai Yang , Suet Chung Yeung
IPC分类号: C07D235/06 , C07D235/24 , C07D295/125 , C07D401/12 , C07D471/04 , A61K45/06 , C07D235/08 , A61K31/4184 , A61K31/5377 , A61K31/454 , A61K31/437 , A61K31/506 , A61K31/497 , A61K31/55 , A61K31/541 , A61K31/439 , C07D405/12 , C07D405/14 , C07D471/08 , A61K31/553 , C07D235/30 , C07D235/14 , C07D401/04 , C07D235/12 , A61K31/444 , A61K31/4545 , A61K31/538 , A61K31/5386 , A61K31/438 , C07D403/12 , A61K31/4439 , C07D413/12 , A61K31/496 , C07D487/04 , A61K31/4725 , C07D235/28 , C07D235/16 , C07D409/12
CPC分类号: C07D471/04 , A61K31/4184 , A61K31/437 , A61K31/438 , A61K31/439 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4545 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5386 , A61K31/541 , A61K31/55 , A61K31/553 , A61K45/06 , C07D235/06 , C07D235/08 , C07D235/12 , C07D235/14 , C07D235/16 , C07D235/24 , C07D235/28 , C07D235/30 , C07D295/125 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D471/08 , C07D487/04
摘要: The present disclosure provides indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors of Formula I: or pharmaceutically acceptable salts thereof, in which X, L, n, m, R1, R2a, R2b, Rn, Rm, and Rt are as defined herein, as well as pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts thereof, and methods of using the same to treat conditions mediated by IDO1.
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公开(公告)号:US09504689B2
公开(公告)日:2016-11-29
申请号:US14635830
申请日:2015-03-02
发明人: Dustin Siegel , David Sperandio , Hai Yang , Michael Sangi , Jay P. Parrish , Hon Chung Hui
IPC分类号: A61K31/519 , A61K31/5377 , C07D487/04 , C07D519/00 , C07D471/04 , A61K45/06 , A61K31/4545 , A61K31/5025 , A61K31/53
CPC分类号: C07D487/04 , A61K31/4545 , A61K31/5025 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D519/00
摘要: Compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections are provided. The compounds and compositions are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.
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公开(公告)号:US20160031868A1
公开(公告)日:2016-02-04
申请号:US14774019
申请日:2014-03-27
发明人: Evangelos Aktoudianakis , Gregory Chin , Britton Kenneth Corkey , Jinfa Du , Kristyna Elbel , Robert H. Jiang , Tetsuya Kobayashi , Ruben Martinez , Samuel E. Metobo , Michael Mish , Sophie Shevick , David Sperandio , Hai Yang , Jeff Zablocki
IPC分类号: C07D413/14
CPC分类号: C07D413/14 , C07D413/04 , C07D417/14
摘要: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2a, R2b, R3, and X are described herein.
摘要翻译: 本申请涉及可用作含溴结构域的蛋白质(包括含溴结构域蛋白质的蛋白质4(BRD4))的抑制剂或其它方式调节其含有活性的蛋白质的化学化合物,以及含有这些化合物的组合物和制剂,以及 使用和制造这些化合物。 化合物包括其中R1a,R1b,R2a,R2b,R3和X在本文中描述的式(I)的化合物。
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公开(公告)号:US08980878B2
公开(公告)日:2015-03-17
申请号:US13865069
申请日:2013-04-17
发明人: Dustin Siegel , David Sperandio , Hai Yang , Michael Sangi , Jay P. Parrish , Hon Chung Hui
IPC分类号: A61K31/00 , C07D413/00
CPC分类号: C07D487/04 , A61K31/4545 , A61K31/5025 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D519/00
摘要: Compounds and pharmaceutically acceptable salts and esters and compositions thereof, for treating viral infections are provided. The compounds and compositions are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.
摘要翻译: 提供了用于治疗病毒感染的化合物及其药学上可接受的盐和酯及其组合物。 化合物和组合物可用于治疗肺炎链球菌病毒感染。 提供的化合物,组合物和方法特别可用于治疗人呼吸道合胞病毒感染。
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公开(公告)号:US08809330B2
公开(公告)日:2014-08-19
申请号:US14069685
申请日:2013-11-01
发明人: Kerim Babaoglu , Constantine G. Boojamra , Eugene J. Eisenberg , Hon Chung Hui , Richard L. Mackman , Jay P. Parrish , Michael Sangi , Oliver L. Saunders , Dustin Siegel , David Sperandio , Hai Yang
IPC分类号: A61P31/14
CPC分类号: C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D495/04 , C07D513/04 , C07D519/00 , C07F9/65616
摘要: The invention provides compounds of Formula I or Formula II: or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.
摘要翻译: 本发明提供了本文所述的式I或式II化合物或其药学上可接受的盐或酯。 其化合物及其组合物可用于治疗肺炎链球菌病毒感染。 提供的化合物,组合物和方法特别可用于治疗人呼吸道合胞病毒感染。
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公开(公告)号:US20220356196A1
公开(公告)日:2022-11-10
申请号:US17176497
申请日:2021-02-16
发明人: Daniel H. Byun , Gregory F. Chin , Byoung-kwon Chun , Michael O. Clarke , Bindu Goyal , Hon C. Hui , Petr Jansa , Richard L. Mackman , Michael R. Mish , Dustin S. Siegel , David Sperandio , Hai Yang , Lijun Zhang
IPC分类号: C07F9/6561
摘要: The present disclosure provides compounds for treating a variety of diseases, such as respiratory syncytial virus (RSV), HRV, hMPV, ebola, Zika, West Nile, Dengue, and HCV.
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公开(公告)号:US20220241281A1
公开(公告)日:2022-08-04
申请号:US17496962
申请日:2021-10-08
发明人: Gregory Chin , Michael O`Neil Hanrahan Clarke , Xiaochun Han , Tim Hansen , Yunfeng Eric Hu , Dmitry Koltun , Ryan McFadden , Michael R. Mish , Eric Q. Parkhill , David Sperandio , Lianhong Xu , Hai Yang
IPC分类号: A61K31/519 , A61K45/06 , C07D471/04 , C07D471/10 , C07D487/04 , C07D519/00
摘要: The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula I, processes for preparing compounds of Formula I, therapeutic methods for treating cancers.
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