公开(公告)号：US20240182476A1

公开(公告)日：2024-06-06

申请号：US18450646

申请日：2023-08-16

Applicant: GILEAD SCIENCES, INC. ,  CARNA BIOSCIENCES, INC.

Inventor： Masaaki Sawa ,  Mai Arai ,  Ryoko Nakai ,  Hirokazu Matsumoto ,  Catherine Pugh ,  Eric Hu ,  Juan Guerrero ,  Jesse Jacobsen ,  Jonathan William Medley ,  Jie Xu ,  Latesh Lad ,  Leena Patel ,  Michael Graupe ,  Qingming Zhu ,  Stephen Holmbo ,  Tetsuya Kobayashi ,  Will Watkins ,  Yasamin Moazami ,  Suet C. Yeung ,  Julian A. Codelli ,  Heath A. Weaver

IPC: C07D487/04 ,  A61K31/395 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/55 ,  A61K31/553 ,  A61K31/695 ,  A61K31/704 ,  A61K31/7068 ,  A61K35/15 ,  A61K35/17 ,  A61K39/395 ,  A61K45/06 ,  C07D519/00 ,  C07F7/18

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/55 ,  A61K31/553 ,  A61K31/5545 ,  A61K31/695 ,  A61K31/704 ,  A61K31/7068 ,  A61K35/15 ,  A61K35/17 ,  A61K39/3955 ,  A61K45/06 ,  C07D519/00 ,  C07F7/1804

Abstract: The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.

公开(公告)号：US20230270719A1

公开(公告)日：2023-08-31

申请号：US18059806

申请日：2022-11-29

Applicant: Gilead Sciences, Inc.

Inventor： Jinfa Du ,  Joshua A. Kaplan ,  Thorsten A. Kirschberg ,  Tetsuya Kobayashi ,  Scott E. Lazerwith ,  Rick Andrew Lee ,  Jonathan William Medley ,  Michael L. Mitchell ,  Philip Anthony Morganelli ,  Hyung-Jung Pyun ,  Sophia L. Shevick ,  Neil H. Squires ,  William J. Watkins

IPC: A61K31/403 ,  C07D487/04 ,  C07D519/00 ,  A61P31/20 ,  A61K31/03 ,  A61K31/16 ,  A61K31/38 ,  A61K31/4192

CPC classification number: A61K31/403 ,  C07D487/04 ,  C07D519/00 ,  A61P31/20 ,  A61K31/03 ,  A61K31/16 ,  A61K31/38 ,  A61K31/4192

Abstract: This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.

公开(公告)号：US20230148157A1

公开(公告)日：2023-05-11

申请号：US17862896

申请日：2022-07-12

Applicant: Gilead Sciences, Inc.

Inventor： David Alan Gutierrez ,  Tetsuya Kobayashi ,  Scott E. Lazerwith ,  Rick Andrew Lee ,  Philip Anthony Morganelli ,  Hyung-Jung Pyun

IPC: C07D487/04 ,  A61P31/20

CPC classification number: C07D487/04 ,  A61P31/20

Abstract: This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.

公开(公告)号：US11420974B2

公开(公告)日：2022-08-23

申请号：US17070236

申请日：2020-10-14

Applicant: GILEAD SCIENCES, INC.

Inventor： David Alan Gutierrez ,  Tetsuya Kobayashi ,  Scott E. Lazerwith ,  Rick Andrew Lee ,  Philip Anthony Morganelli ,  Hyung-Jung Pyun

IPC: C07D487/04 ,  A61P31/20

Abstract: This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.

公开(公告)号：US20210171543A1

公开(公告)日：2021-06-10

申请号：US17094447

申请日：2020-11-10

Applicant: Gilead Sciences, Inc.

Inventor： Hang Chu ,  Juan A. Guerrero ,  Anna E. Hurtley ,  Lan Jiang ,  Darryl Kato ,  Tetsuya Kobayashi ,  David W. Lin ,  Jonathan William Medley ,  Devan Naduthambi ,  Vickie H. Tsui ,  Chandrasekar Venkataramani ,  William J. Watkins ,  Hong Yang ,  QingMing Zhu

IPC: C07D513/18 ,  C07D519/00 ,  C07D513/20 ,  C07D513/08 ,  C07D513/22 ,  A61K45/06 ,  C07K16/28

Abstract: The present disclosure generally relates to compounds of Formula (I) and pharmaceutical compositions that may be used in methods of treating cancer.

公开(公告)号：US20200331870A1

公开(公告)日：2020-10-22

申请号：US16857021

申请日：2020-04-23

Applicant: Gilead Sciences, Inc.

Inventor： Hang Chu ,  Juan A. Guerrero ,  Anna E. Hurtley ,  Tae H. Hwang ,  Lan Jiang ,  Darryl Kato ,  Tetsuya Kobayashi ,  John E. Knox ,  Scott E. Lazerwith ,  Xiaofen Li ,  David W. Lin ,  Jonathan W. Medley ,  Michael L. Mitchell ,  Devan Naduthambi ,  Zachary Newby ,  Neil H. Squires ,  Vickie H. Tsui ,  Chandrasekar Venkataramani ,  William J. Watkins ,  Hong Yang

IPC: C07D267/20 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

Abstract: The present disclosure generally relates to compounds and pharmaceutical compositions that may be used in methods of treating cancer.

公开(公告)号：US20190292187A1

公开(公告)日：2019-09-26

申请号：US16284812

申请日：2019-02-25

Applicant: Gilead Sciences, Inc.

Inventor： David Alan Gutierrez ,  Tetsuya Kobayashi ,  Scott E. Lazerwith ,  Rick Andrew Lee ,  Philip Anthony Morganelli ,  Hyung-Jung Pyun

IPC: C07D487/04 ,  A61P31/20

Abstract: This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.

公开(公告)号：US09655944B2

公开(公告)日：2017-05-23

申请号：US15185273

申请日：2016-06-17

Applicant: Gilead Sciences, Inc.

Inventor： Kyla Bjornson ,  Eda Canales ,  Jeromy J. Cottell ,  Kapil K. Karki ,  Ashley A. Katana ,  Darryl Kato ,  Tetsuya Kobayashi ,  John O. Link ,  Ruben Martinez ,  Barton W. Phillips ,  Hyung-jung Pyun ,  Michael Sangi ,  Adam J. Schrier ,  Dustin Siegel ,  James G. Taylor ,  Chinh V. Tran ,  Teresa A. Trejo Martin ,  Randall W. Vivian ,  Zheng-Yu Yang ,  Jeff Zablocki ,  Sheila Zipfel

IPC: A61K38/21 ,  A61K38/06 ,  C07D498/16 ,  A61K31/4985 ,  C07D498/22 ,  A61K31/4745 ,  A61K31/506 ,  A61K31/519 ,  A61K45/06 ,  C07K5/087 ,  C07K5/08 ,  C07K5/083 ,  A61K38/00

CPC classification number: A61K31/498 ,  A61K31/10 ,  A61K31/401 ,  A61K31/4745 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/519 ,  A61K38/00 ,  A61K38/06 ,  A61K38/21 ,  A61K45/06 ,  C07D241/36 ,  C07D403/14 ,  C07D498/16 ,  C07D498/22 ,  C07K5/08 ,  C07K5/0808 ,  C07K5/0812 ,  C07K5/0827 ,  A61K2300/00

Abstract: Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.

公开(公告)号：US20150175655A1

公开(公告)日：2015-06-25

申请号：US14412331

申请日：2013-07-02

Applicant: Gilead Sciences, Inc.

Inventor： Kyla Bjornson ,  Eda Canales ,  Jeromy J. Cottell ,  Kapil Kumar Karki ,  Ashley Anne Katana ,  Darryl Kato ,  Tetsuya Kobayashi ,  John O. Link ,  Ruben Martinez ,  Barton W. Phillips ,  Hyung-Jung Pyun ,  Michael Sangi ,  Adam James Schrier ,  Dustin Siegel ,  James G. Taylor ,  Chinh Viet Tran ,  Teresa Alejandra Trejo Martin ,  Randall W. Vivian ,  Zheng-Yu Yang ,  Jeff Zablocki ,  Sheila Zipfel

IPC: C07K5/08 ,  A61K38/06 ,  A61K45/06

Abstract: Compounds of Formula I are disclosed, As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.

Abstract translation: 公开了式I的化合物，以及其药学上可接受的盐。 还公开了使用所述化合物和含有所述化合物的药物组合物的方法。

公开(公告)号：US12161625B2

公开(公告)日：2024-12-10

申请号：US18059806

申请日：2022-11-29

Applicant: Gilead Sciences, Inc.

Inventor： Jinfa Du ,  Joshua A. Kaplan ,  Thorsten A. Kirschberg ,  Tetsuya Kobayashi ,  Scott E. Lazerwith ,  Rick Andrew Lee ,  Jonathan William Medley ,  Michael L. Mitchell ,  Philip Anthony Morganelli ,  Hyung-Jung Pyun ,  Sophia L. Shevick ,  Neil H. Squires ,  William J. Watkins

IPC: A61K31/403 ,  A61K31/03 ,  A61K31/16 ,  A61K31/38 ,  A61K31/4192 ,  A61P31/20 ,  C07D487/04 ,  C07D519/00

Abstract: This application relates generally to certain substituted pyrrolizine compounds, and pharmaceutical compositions which inhibit HBV replication, and methods of making and using them.