公开(公告)号：US20210403497A1

公开(公告)日：2021-12-30

申请号：US17209639

申请日：2021-03-23

Applicant: Gilead Sciences, Inc.

Inventor： Thomas Butler ,  Aesop Cho ,  Benjamin R. Graetz ,  Choung U. Kim ,  Samuel E. Metobo ,  Oliver L. Saunders ,  Andrew W. Waltman ,  Jie Xu ,  Lijun Zhang

IPC: C07H1/00 ,  C07H19/23

Abstract: Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,2-f][1,2,4]triazinyl heterocycles of Formula I.

公开(公告)号：US20210024494A1

公开(公告)日：2021-01-28

申请号：US16923750

申请日：2020-07-08

Applicant: Gilead Sciences, Inc.

Inventor： Evangelos Aktoudianakis ,  Aesop Cho ,  Michael Graupe ,  Lateshkumar Thakorlal Lad ,  Paulo A. Machicao Tello ,  Jonathan William Medley ,  Samuel E. Metobo ,  Devan Naduthambi ,  Barton W. Phillips ,  Scott Preston Simonovich ,  Peiyuan Wang ,  William J. Watkins ,  Jie Xu ,  Kin Shing Yang ,  Christopher Allen Ziebenhaus

IPC: C07D401/14 ,  A61K31/444 ,  A61K31/497 ,  A61K31/704 ,  A61K31/7068 ,  A61K39/395 ,  C07D471/08

Abstract: Compounds and methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.

公开(公告)号：US20200157094A1

公开(公告)日：2020-05-21

申请号：US16660219

申请日：2019-10-22

Applicant: Gilead Sciences, Inc.

Inventor： Zhimin Du ,  Michael Graupe ,  Paulo A. Machicao Tello ,  Jonathan William Medley ,  Samuel E. Metobo ,  Eric Q. Parkhill ,  Barton W. Phillips ,  Scott P. Simonovich ,  Peiyuan Wang ,  Jie Xu ,  Christopher A. Ziebenhaus

IPC: C07D471/04 ,  C07D513/04 ,  C07D401/12 ,  C07D413/10 ,  C07D217/04 ,  C07D401/14 ,  C07D471/08 ,  C07D487/04 ,  C07D495/04

Abstract: Compounds and methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.

公开(公告)号：US11555029B2

公开(公告)日：2023-01-17

申请号：US16891880

申请日：2020-06-03

Applicant: Gilead Sciences, Inc.

Inventor： Evangelos Aktoudianakis ,  Aesop Cho ,  Zhimin Du ,  Michael Graupe ,  Lateshkumar Thakorlal Lad ,  Paulo A. Machicao Tello ,  Jonathan William Medley ,  Samuel E. Metobo ,  Prasenjit Kumar Mukherjee ,  Devan Naduthambi ,  Eric Q. Parkhill ,  Barton W. Phillips ,  Scott Preston Simonovich ,  Neil H. Squires ,  Peiyuan Wang ,  William J. Watkins ,  Jie Xu ,  Kin Shing Yang ,  Christopher Allen Ziebenhaus

IPC: C07D403/14 ,  A61P31/20 ,  A61P35/02 ,  A61K31/496 ,  C07D519/00 ,  C07D241/20 ,  C07D487/10 ,  C07D405/14 ,  C07D487/08 ,  A61K31/497 ,  C07D491/107 ,  C07D241/18 ,  A61P35/00 ,  C07K16/28

Abstract: Compounds of Formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.

公开(公告)号：US20210053946A1

公开(公告)日：2021-02-25

申请号：US16891880

申请日：2020-06-03

Applicant: Gilead Sciences, Inc.

Inventor： Evangelos Aktoudianakis ,  Aesop Cho ,  Zhimin Du ,  Michael Graupe ,  Lateshkumar Thakorlal Lad ,  Paulo A. Machicao Tello ,  Jonathan William Medley ,  Samuel E. Metobo ,  Prasenjit Kumar Mukherjee ,  Devan Naduthambi ,  Eric Q. Parkhill ,  Barton W. Phillips ,  Scott Preston Simonovich ,  Neil H. Squires ,  Peiyuan Wang ,  William J. Watkins ,  Jie Xu ,  Kin Shing Yang ,  Christopher Allen Ziebenhaus

IPC: C07D403/14 ,  A61P31/20 ,  A61P35/02 ,  A61K31/496 ,  C07D519/00 ,  C07D241/20 ,  C07D487/10 ,  C07D405/14 ,  C07D487/08 ,  A61K31/497 ,  C07D491/107 ,  C07D241/18 ,  A61P35/00

Abstract: Compounds of Formula (I), methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.

公开(公告)号：US10899735B2

公开(公告)日：2021-01-26

申请号：US16388517

申请日：2019-04-18

Applicant: Gilead Sciences, Inc

Inventor： Evangelos Aktoudianakis ,  Aesop Cho ,  Zhimin Du ,  Michael Graupe ,  Lateshkumar Thakorlal Lad ,  Paulo A. Machicao Tello ,  Jonathan William Medley ,  Samuel E. Metobo ,  Prasenjit Kumar Mukherjee ,  Devan Naduthambi ,  Eric Q. Parkhill ,  Barton W. Phillips ,  Scott Preston Simonovich ,  Neil H. Squires ,  Peiyuan Wang ,  William J. Watkins ,  Jie Xu ,  Kin Shing Yang ,  Christopher Allen Ziebenhaus

IPC: C07D401/10 ,  A61K31/444 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D487/10 ,  C07D519/00 ,  C07K16/28

Abstract: Compounds and methods of using said compounds singly or in combination with additional agents and compositions of said compounds for the treatment of cancer are disclosed.

公开(公告)号：US20210017170A1

公开(公告)日：2021-01-21

申请号：US16911643

申请日：2020-06-25

Applicant: Gilead Sciences, Inc.

Inventor： Evangelos Aktoudianakis ,  Andrea Ambrosi ,  Sylvie M. Asselin ,  Florence J. Bachrach ,  Pavel R. Badalov ,  Gregory F. Chin ,  Stephen P. Lathrop ,  Willard Lew ,  Richard L. Mackman ,  Jeffrey E. Merit ,  Samuel E. Metobo ,  Michael R. Mish ,  Beau P. Pritchett ,  Hyung-Jung Pyun ,  Christopher S. Regens ,  Tiago Vieira ,  Xianghong Wang ,  Adam B. Weinstein ,  Todd A. Wenderski ,  Zehua Zheng

IPC: C07D471/04 ,  C07D213/81 ,  C07D413/04

Abstract: The present disclosure provides methods for preparing (R)-2-((2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino)-2-methylhexan-1-ol or a salt thereof and related key intermediates.

公开(公告)号：US20170342068A1

公开(公告)日：2017-11-30

申请号：US15596844

申请日：2017-05-16

Applicant: Gilead Sciences, Inc.

Inventor： Evangelos Aktoudianakis ,  Eda Canales ,  Elbert Chin ,  Kevin S. Currie ,  Ashley Anne Katana ,  Darryl Kato ,  John O. Link ,  Samuel E. Metobo ,  Roland D. Saito ,  Zheng-Yu Yang

IPC: C07D471/04

CPC classification number: C07D471/04 ,  A61K31/5025

Abstract: The present disclosure generally relates to compounds and pharmaceutical compositions which may be used in methods of treating a hepatitis B virus infection.

公开(公告)号：US20160376261A1

公开(公告)日：2016-12-29

申请号：US15239422

申请日：2016-08-17

Applicant: Gilead Sciences, Inc.

Inventor： Evangelos Aktoudianakis ,  Gregory Chin ,  Britton Kenneth Corkey ,  Jinfa Du ,  Kristyna Elbel ,  Robert H. Jiang ,  Tetsuya Kobayashi ,  Rick Lee ,  Ruben Martinez ,  Samuel E. Metobo ,  Michael Mish ,  Manuel Munoz ,  Sophie Shevick ,  David Sperandio ,  Hai Yang ,  Jeff Zablocki

IPC: C07D413/04 ,  C07D453/02 ,  C07D417/14 ,  C07D413/14 ,  C07D471/04

CPC classification number: C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  C07D453/02 ,  C07D471/04

Abstract: This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R1a, R1b, R2a, R2b, R3, R4a, R4b, and R5 are described herein.

Abstract translation: 其中R1a，R1b，R2a，R2b，R3，R4a，R4b和R5如本文所述。

公开(公告)号：US20160289229A1

公开(公告)日：2016-10-06

申请号：US15059070

申请日：2016-03-02

Applicant: Gilead Sciences, Inc.

Inventor： Evangelos Aktoudianakis ,  Gregory Chin ,  Richard L. Mackman ,  Samuel E. Metobo ,  Michael R. Mish ,  Hyung-jung Pyun ,  Jeff Zablocki

IPC: C07D471/04

CPC classification number: A61K31/517 ,  C07D239/84 ,  C07D401/04 ,  C07D471/04

Abstract: The present disclosure relates generally to toll like receptor modulator compounds, such as diamino pyrido[3,2 D]pyrimidine compounds and pharmaceutical compositions which, among other things, modulate toll-like receptors (e.g. TLR-8), and methods of making and using them.

Abstract translation: 本公开内容一般涉及诸如二氨基吡啶并[3,2 D]嘧啶化合物等受体调节剂化合物和除其他外调节toll样受体（例如TLR-8）的药物组合物，以及制备和 使用它们。