Methods, systems, and media for interacting with content using a second screen device are provided. In some implementations, the method comprises: receiving, from a remote media streaming device, a request to present media content items; sending, over the Internet, interactive content to the media streaming device as a stream of video; causing the interactive content to be presented by the media streaming device; causing a notification to be sent to a computing device associated with the media streaming device indicating that the content being presented by the media streaming device is interactive content; receiving instructions from the computing device to control how an object depicted in the interactive content is presented; updating the interactive content based on the instructions; sending the updated interactive content to the media streaming device as a stream of video; and causing the updated interactive content to be presented by the media streaming device.