发明授权
- 专利标题： Coumarin-7-yloxy-alkyl piperazine compounds
- 专利标题（中）： COUMARIN-7-YLOXY-ALKYL PIPERAZINE化合物
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申请号： US24560772申请日： 1972-04-19
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公开(公告)号： US3810898A公开(公告)日： 1974-05-14
- 发明人: WITTE ERNST-CHRISTIAN , STACH KURT , THIEL MAX , ROESCH ANDRONIKI , ROESCH EGON
- 申请人： BOEHRINGER MANNHEIM GMBH
- 专利权人： Boehringer Mannheim Gmbh
- 当前专利权人： Boehringer Mannheim Gmbh
- 优先权： DE2123924 1971-05-14
- 主分类号： C07D309/16
- IPC分类号： C07D309/16 ; A61K31/35 ; A61K31/351 ; A61K31/352 ; A61K31/495 ; A61P3/00 ; A61P29/00 ; A61P37/08 ; C07D309/32 ; C07D311/16 ; C07D51/70
摘要：
CERTAIN NOVEL 4-(W-(COUMARIN-7-YLOXY)-ALKYL)-PIPERAZINE COMPOUNDS OF THE FORMULA:
3-R1,4-R2,7-((4-R3-PIPERAZINO)-(CH2)N-O-)-2H-CHROMEN-2-ONE
WHEREIN R1 IS HYDROGEN ATOM OR A LOWER ALKYL; R2 IS LOWER ALKYL; R3 IS AN UNSUBSTITUTED OR SUBSTITUTED PHENYL OR BENZYL RADICAL, THE SUBSTITUENTS, WHEN PRESENT, BEING HALOGEN OR LOWER ALKYL OR ALKOXY GROUPS, AND N IS 1, 2 OR 3, AND THE PHARMACOLOGICALLY COMPATIBLE SALTS THEREOF; HAVE OUTSTANDING ANTI-OEDEMATOUS ACTIVITY AND REDUCE INCREASED CAPILLARY PERMEABILITY.
3-R1,4-R2,7-((4-R3-PIPERAZINO)-(CH2)N-O-)-2H-CHROMEN-2-ONE
WHEREIN R1 IS HYDROGEN ATOM OR A LOWER ALKYL; R2 IS LOWER ALKYL; R3 IS AN UNSUBSTITUTED OR SUBSTITUTED PHENYL OR BENZYL RADICAL, THE SUBSTITUENTS, WHEN PRESENT, BEING HALOGEN OR LOWER ALKYL OR ALKOXY GROUPS, AND N IS 1, 2 OR 3, AND THE PHARMACOLOGICALLY COMPATIBLE SALTS THEREOF; HAVE OUTSTANDING ANTI-OEDEMATOUS ACTIVITY AND REDUCE INCREASED CAPILLARY PERMEABILITY.
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