公开(公告)号：US3810898A

公开(公告)日：1974-05-14

申请号：US24560772

申请日：1972-04-19

申请人： BOEHRINGER MANNHEIM GMBH

发明人： WITTE ERNST-CHRISTIAN ,  STACH KURT ,  THIEL MAX ,  ROESCH ANDRONIKI ,  ROESCH EGON

IPC分类号： C07D309/16 ,  A61K31/35 ,  A61K31/351 ,  A61K31/352 ,  A61K31/495 ,  A61P3/00 ,  A61P29/00 ,  A61P37/08 ,  C07D309/32 ,  C07D311/16 ,  C07D51/70

CPC分类号： C07D311/16 ,  Y10S514/87

摘要： CERTAIN NOVEL 4-(W-(COUMARIN-7-YLOXY)-ALKYL)-PIPERAZINE COMPOUNDS OF THE FORMULA:

3-R1,4-R2,7-((4-R3-PIPERAZINO)-(CH2)N-O-)-2H-CHROMEN-2-ONE

WHEREIN R1 IS HYDROGEN ATOM OR A LOWER ALKYL; R2 IS LOWER ALKYL; R3 IS AN UNSUBSTITUTED OR SUBSTITUTED PHENYL OR BENZYL RADICAL, THE SUBSTITUENTS, WHEN PRESENT, BEING HALOGEN OR LOWER ALKYL OR ALKOXY GROUPS, AND N IS 1, 2 OR 3, AND THE PHARMACOLOGICALLY COMPATIBLE SALTS THEREOF; HAVE OUTSTANDING ANTI-OEDEMATOUS ACTIVITY AND REDUCE INCREASED CAPILLARY PERMEABILITY.

公开(公告)号：US3912756A

公开(公告)日：1975-10-14

申请号：US45025474

申请日：1974-03-11

申请人： BOEHRINGER MANNHEIM GMBH

发明人： WOLFF HANS PETER ,  WITTE ERNST-CHRISTIAN ,  STACH KURT ,  STORK HARALD ,  ROESCH EGON

IPC分类号： C07D209/42 ,  C07D213/82 ,  C07D215/48 ,  C07D221/16 ,  C07D231/14 ,  C07D231/16 ,  C07D261/18 ,  C07D277/20 ,  C07D277/56 ,  C07D333/38 ,  C07D209/18 ,  C07D213/56

CPC分类号： C07D213/82 ,  C07D209/42 ,  C07D215/48 ,  C07D221/16 ,  C07D231/14 ,  C07D261/18 ,  C07D277/56 ,  C07D333/38 ,  Y10S514/824

摘要： Novel phenoxyalkyl-carboxylic acid derivatives of the formula

wherein R1 and R2, which may be the same or different, are hydrogen or methyl; N IS 1 OR 2; Z is hydroxyl or alkoxy; and Y is a 5- or 6-membered heterocyclic ring containing, as hetero atoms, 1 or 2 sulfur, oxygen or nitrogen atoms, which heterocyclic ring may be substituted by halogen atoms or lower alkyl, alkoxy or alkoxyalkoxy radicals and may also contain a fused benzene nucleus, which can be substituted by halogen atoms or alkoxy or an alkylene radical; AND THE PHARMOCOLOGICALLY COMPATIBLE SALTS THEREOF, ARE OUTSTANDINGLY EFFECTIVE AS SERUM LIPID DEPRESSANTS AND ARE THUS EFFECTIVE THERAPEUTIC AGENTS IN THE TREATMENT OF ATHEROSCLEROSIS.

摘要翻译： 式R1 | Y-CO-NH-（CH2）n -O-C-CO-Z | R2的新型苯氧基烷基 - 羧酸衍生物，其中可以相同或不同的R 1和R 2是氢或甲基; N IS 1 OR 2; Z是羟基或烷氧基; Y为5或6元杂环，杂环为1或2个硫，氧或氮原子，该杂环可被卤素原子或低级烷基，烷氧基或烷氧基烷氧基取代，也可含有 稠合的苯核，其可以被卤素原子或烷氧基或亚烷基取代; 并且其药理学兼容的盐，作为血清脂质沉着剂是非常有效的，并且是有效的治疗药物治疗甲状腺功能亢进症。