公开(公告)号：US3810898A

公开(公告)日：1974-05-14

申请号：US24560772

申请日：1972-04-19

申请人： BOEHRINGER MANNHEIM GMBH

发明人： WITTE ERNST-CHRISTIAN ,  STACH KURT ,  THIEL MAX ,  ROESCH ANDRONIKI ,  ROESCH EGON

IPC分类号： C07D309/16 ,  A61K31/35 ,  A61K31/351 ,  A61K31/352 ,  A61K31/495 ,  A61P3/00 ,  A61P29/00 ,  A61P37/08 ,  C07D309/32 ,  C07D311/16 ,  C07D51/70

CPC分类号： C07D311/16 ,  Y10S514/87

摘要： CERTAIN NOVEL 4-(W-(COUMARIN-7-YLOXY)-ALKYL)-PIPERAZINE COMPOUNDS OF THE FORMULA:

3-R1,4-R2,7-((4-R3-PIPERAZINO)-(CH2)N-O-)-2H-CHROMEN-2-ONE

WHEREIN R1 IS HYDROGEN ATOM OR A LOWER ALKYL; R2 IS LOWER ALKYL; R3 IS AN UNSUBSTITUTED OR SUBSTITUTED PHENYL OR BENZYL RADICAL, THE SUBSTITUENTS, WHEN PRESENT, BEING HALOGEN OR LOWER ALKYL OR ALKOXY GROUPS, AND N IS 1, 2 OR 3, AND THE PHARMACOLOGICALLY COMPATIBLE SALTS THEREOF; HAVE OUTSTANDING ANTI-OEDEMATOUS ACTIVITY AND REDUCE INCREASED CAPILLARY PERMEABILITY.

公开(公告)号：US3917596A

公开(公告)日：1975-11-04

申请号：US39436673

申请日：1973-09-04

申请人： BOEHRINGER MANNHEIM GMBH

发明人： WINTER WERNER ,  THIEL MAX ,  STACH KURT ,  SCHAUMANN WOLFGANG ,  ROESCH ANDRONIKI

IPC分类号： C07D473/34 ,  A61K20060101 ,  A61K31/52 ,  C07D20060101 ,  C07D241/04 ,  C07D295/04 ,  C07D295/12

CPC分类号： C07D473/00 ,  Y10S514/87

摘要： A 9-((4-phenyl-piperazino)-alkyl)-adenine of the formula

wherein A is a lower alkylene radical, and R is a hydrogen or halogen atom or a lower alkoxy radical, or a salt thereof with a pharmacologically compatible acid, which compounds are characterized by marked anti-edematous activity as well as by activity in reducing capillary permeability.

摘要翻译： 式NH 2 |（I）| | A-NN的9 - [（4-苯基 - 哌嗪子基） - 烷基] - 腺嘌呤其中A是低级亚烷基，R是氢或卤素原子或低级烷氧基 ，或其盐与药理学上相容的酸，该化合物的特征在于明显的抗水肿活性以及降低毛细血管通透性的活性。

公开(公告)号：US3919226A

公开(公告)日：1975-11-11

申请号：US47879974

申请日：1974-06-12

申请人： BOEHRINGER MANNHEIM GMBH

发明人： THIEL MAX ,  FRIEBE WALTER-GUNAR ,  STACH KURT ,  ROESCH EGON ,  ROESCH ANDRONIKI

IPC分类号： C07D473/34 ,  A61K31/41 ,  A61K31/52 ,  C07D241/04 ,  C07D295/12 ,  C07D403/12 ,  C07D473/32

CPC分类号： C07D473/00 ,  Y10S514/87

摘要： WHEREIN R1 is hydrogen or lower alkyl; R2 is phenyl or benzyl, optionally substituted by halogen, lower alkyl or lower alkoxy; and A is lower alkylene optionally substituted by a hydroxyl group; AND THE PHARMACOLOGICALLY COMPATIBLE SALTS THEREOF; HAVE OUTSTANDING ANTI-OEDEMA, ANTI-INFLAMMATORY AND ANTI-ALLERGIC ACTIVITY.

New purine compounds of the formula

摘要翻译： 式WHEREIN R1的新嘌呤化合物是氢或低级烷基; R2是苯基或苄基，任选被卤素，低级烷基或低级烷氧基取代; A是任选被羟基取代的低级亚烷基; 及其药理学兼容性; 具有抗病毒，抗炎和抗过敏活性。