发明授权
US4144329A Antitumor antibiotics MA 144-M.sub.1 and MA 144-M.sub.2
失效
抗肿瘤抗生素MA 144-M {HD 1 {B和MA 144-M {HD 2
- 专利标题： Antitumor antibiotics MA 144-M.sub.1 and MA 144-M.sub.2
- 专利标题（中）： 抗肿瘤抗生素MA 144-M {HD 1 {B和MA 144-M {HD 2
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申请号： US780730申请日： 1977-03-24
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公开(公告)号： US4144329A公开(公告)日： 1979-03-13
- 发明人: Hamao Umezawa , Tomio Takeuchi , Hiroshi Naganawa , Masaaki, all of Ishizuka , Norio Shibamoto , Toshikazu Oki , Taiji Inui
- 申请人： Hamao Umezawa , Tomio Takeuchi , Hiroshi Naganawa , Masaaki, all of Ishizuka , Norio Shibamoto , Toshikazu Oki , Taiji Inui
- 申请人地址： JPX Tokyo
- 专利权人： Zaidan Hojin Biseibutsu Kagaku KenkyuKai
- 当前专利权人： Zaidan Hojin Biseibutsu Kagaku KenkyuKai
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX51-39688 19760407
- 主分类号： A61K31/70
- IPC分类号： A61K31/70 ; A61K31/7028 ; A61K31/7034 ; A61K31/704 ; A61P31/04 ; A61P35/00 ; C07H15/252 ; C12P19/56 ; A61K31/71 ; C07H17/08
摘要：
New antitumor agents designated MA 144-M.sub.1 and MA 144-M.sub.2, which are anthracycline glycosides and inhibit the growth of gram-positive bacteria, e.g. Staphyococcus aureaus, Bacillus subtilis and Sarcina lutea, and inhibit the growth of animal tumors such as leukemia L 1210, P 388 and sarcoma 180 are produced by fermentation of MA 144-producing strains of streptomyces and by the chemical or enzymatic conversion of aclacinomycin A or cinerubin A.
公开/授权文献
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