发明授权
US4588734A Blood pressure lowering n-pyridyl-, n-quinolyl-, and n-piperdyl-n-acyl
amino acid derivatives and method
失效
血压降低正丁基 - 正正喹啉基和正 - 哌啶基-N-酰基氨基酸衍生物及方法
- 专利标题： Blood pressure lowering n-pyridyl-, n-quinolyl-, and n-piperdyl-n-acyl amino acid derivatives and method
- 专利标题（中）： 血压降低正丁基 - 正正喹啉基和正 - 哌啶基-N-酰基氨基酸衍生物及方法
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申请号： US672645申请日： 1984-11-19
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公开(公告)号： US4588734A公开(公告)日： 1986-05-13
- 发明人: John T. Suh , Jerry W. Skiles , Bruce E. Williams , Alfred Schwab
- 申请人： John T. Suh , Jerry W. Skiles , Bruce E. Williams , Alfred Schwab
- 申请人地址： NY Tarrytown
- 专利权人： USV Pharmaceutical Corp.
- 当前专利权人： USV Pharmaceutical Corp.
- 当前专利权人地址： NY Tarrytown
- 主分类号： A61K31/445
- IPC分类号： A61K31/445 ; C07D207/08 ; C07D211/26 ; C07D213/40 ; C07D213/75 ; C07D217/22 ; C07D219/14 ; C07D235/30 ; C07D239/42 ; C07D277/46 ; C07D307/52 ; C07D307/66 ; C07D307/82 ; C07D309/14 ; C07D317/66 ; C07D319/18 ; C07D333/20 ; C07D333/36 ; C07D333/48 ; A61K31/47 ; C07D215/38
摘要：
Compounds of the structure: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are hydrogen, alkyl, alkenyl, alkynyl, phenyl-alkyl, or cycloalkyl,n is an integer from 0 to 4 inclusive,M is heterocyclic or heterocyclic alkyl,Y is hydroxy, alkoxy, amino, or substituted amino, amino-alkanoyl, aryloxy, aminoalkoxy, or hydroxyalkoxy, andR.sub.7 is hydrogen, alkanoyl, carboxylalkanoyl, hydroxyalkanoyl, amino-alkanoyl, cyano, amidino, carbalkoxy, ZS, or ##STR2## wherein Z is hydrogen, alkyl, hydroxyalkyl, aminoalkyl or the radical ##STR3## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, n, M and Y are as described above; and where Y is hydroxy their nontoxic, pharmaceutically acceptable alkali metal, alkaline earth metal, and amine salts.These compounds possess antihypertensive and angiotensin converting enzyme inhibitory activity.
公开/授权文献
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