发明授权
- 专利标题: Acylphenol derivatives, useful as anti-inflammatory agents and pain suppressants
- 专利标题(中): 酰基酚衍生物,可用作抗炎剂和止痛剂
-
申请号: US317601申请日: 1989-03-01
-
公开(公告)号: US4927835A公开(公告)日: 1990-05-22
- 发明人: Masahiro Kise , Yoshihiko Yoshimoto , Hiroshi Fujisawa , Yasuo Sasaki , Shoji Yasufuku
- 申请人: Masahiro Kise , Yoshihiko Yoshimoto , Hiroshi Fujisawa , Yasuo Sasaki , Shoji Yasufuku
- 申请人地址: JPX
- 专利权人: Nippon Shinyaku Co., Ltd.
- 当前专利权人: Nippon Shinyaku Co., Ltd.
- 当前专利权人地址: JPX
- 优先权: JPX63-51977 19880304
- 主分类号: A61K31/13
- IPC分类号: A61K31/13 ; A61K31/34 ; A61K31/341 ; A61K31/38 ; A61K31/381 ; A61K31/40 ; A61K31/445 ; A61K31/495 ; A61K31/535 ; A61K31/5375 ; A61K31/54 ; A61P29/00 ; C07C20060101 ; C07C225/16 ; C07C225/18 ; C07D207/32 ; C07D207/333 ; C07D211/40 ; C07D295/10 ; C07D295/112 ; C07D307/46 ; C07D307/56 ; C07D333/22
摘要:
Compounds of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof, wherein: R.sup.1 is cycloalkyl of 5 to 7 carbon atoms; aryl of 6 to 10 carbon atoms unsubstituted or substituted by straight or branched chain alkyl of 1 to 4 carbon atoms, halo or trifluoromethyl; or ##STR2## wherein A is oxygen, sulfur or NR.sup.5, wherein R.sup.5 is hydrogen, straight or branched chain alkyl of 1 to 4 carbon atoms or halo, and R.sup.6 is hydrogen, straight or branched chain alkyl of 1 to 4 carbon atoms or halo;R.sup.2 is straight or branched chain alkyl of 1 to 4 carbon atoms or cycloalkyl of 5 to 7 carbon atoms; andR.sup.3 and R.sup.4 are the same or different and each is hydrogen; straight or branched chain alkyl of 1 to 8 carbon atoms unsubstituted or substituted by hydroxy, acyloxy of 2 to 5 carbon atoms, carboxyl or carbamoyl;are useful for treating pain, inflammation and fever in humans and animals.
公开/授权文献
- US6026771A Variable actuation of engine valves 公开/授权日:2000-02-22
信息查询