发明授权
US4980509A Aromatic polycyclic derivatives, their process of preparation and their use in human and veterinary medicine and in cosmetics 失效
芳香族多环衍生物,其制备方法及其在人兽药和化妆品中的应用

Aromatic polycyclic derivatives, their process of preparation and their
use in human and veterinary medicine and in cosmetics
摘要:
An aromatic polycyclic compound has the formula ##STR1## wherein R represents --SO.sub.3 H, SO.sub.2 NHR.sub.3, ##STR2## --SO.sub.2 R.sub.3, --SOR.sub.3 or --SR.sub.3, R.sub.3 represents lower alkyl, monohydroxyalkyl, polyhydroxyalkyl, aminoalkyl, carboxyalkyl, aminocarboxyalkyl or alkoxyalkyl,R' represents hydrogen, lower alkyl, lower alkoxy, hydroxy, C.sub.1 -C.sub.4 acyloxy or amino,R" represents hydrogen, lower alkyl or lower alkoxy, orR' and R", taken together, form an oxo, methano or hydroxyimino radical,R.sub.1 represents hydrogen or lower alkyl,n is 0 or 1,when n=1, R.sub.2 represents hydrogen or lower alkyl, or R.sub.1 and R.sub.2, taken together form a vinylene radical, andAr represents an aromatic radical selected from ##STR3## wherein R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10 and R.sub.11 represent hydrogen or lower alkyl, at least one of R.sub.4 and/or R.sub.5 being other than hydrogen, and at least two of R.sub.8 -R.sub.11 being other than hydrogen,A represents methylene or dimethylene substituted or not by lower alkyl; when A represents dimethylene, R.sub.8 and R.sub.10 together can form a methylene or dimethylene radical,and the salts of the compound of formula I as well as their geometric and optical isomers.These compounds are useful in human and veterinary medicines and in cosmetic compositions.
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