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    Aromatic benzopyranyl and benzopyranyl compounds; their preparation; and their use in cosmetic compositions and human and veterinary medicine
    4.
    发明授权
    Aromatic benzopyranyl and benzopyranyl compounds; their preparation; and their use in cosmetic compositions and human and veterinary medicine 失效
    芳香族苯并吡喃基和苯并吡喃基化合物; 他们的准备 以及它们在化妆品组合物和人兽药中的应用

    公开(公告)号：US4829080A

    公开(公告)日：1989-05-09

    申请号：US025200

    申请日：1987-03-12

    申请人： Jean Maignan ,  Gerard Lang ,  Gerard Malle ,  Serge Restle ,  Braham Shroot

    发明人： Jean Maignan ,  Gerard Lang ,  Gerard Malle ,  Serge Restle ,  Braham Shroot

    IPC分类号： A61K8/00 ,  A61K8/36 ,  A61K8/41 ,  A61K8/49 ,  A61K31/35 ,  A61K31/352 ,  A61K31/38 ,  A61K31/382 ,  A61P11/00 ,  A61P17/00 ,  A61P27/02 ,  A61P31/00 ,  A61P35/02 ,  A61P37/00 ,  A61Q5/00 ,  C07D311/04 ,  C07D311/58 ,  C07D335/06

    CPC分类号： C07D335/06 ,  C07D311/58

    摘要： An aromatic benzopyranyl or benzothiopyranyl compound of the formula ##STR1## wherein n is 0 or 1,X represents ##STR2## R' represents H, OH, acyloxy or NH.sub.2, R" represents H or alkoxy orR' and R" taken together form an oxo, methano or hydroxyimino radical,R.sub.8 represents H, ##STR3## R.sub.9 represents H, alkyl, mono or polyhydroxyalkyl, aryl, aralkyl, a residue of a sugar or ##STR4## p equals 1, 2 or 3, r' and r" represent H, alkyl, monohydroxyalkyl, polyhydroxyalkyl, aryl, benzyl, the residue of an amino acid or an aminated sugar, or together form a heterocycle,R.sub.1, R.sub.2, R.sub.3 and R.sub.4 represents H or lower alkyl,R.sub.5, R.sub.6 and R.sub.7 represent H or methyl or when n=1, R.sub.5 and R.sub.7 taken together form with the benzene ring a naphthalene ring (R.sub.5 -R.sub.7 .dbd.--CH.dbd.CH--), andthe salts of said compounds as well as their geometric and optical isomers.These compounds are useful in pharmaceutical and cosmetic compositions.

    摘要翻译： 式（I）的芳香族苯并吡喃基或苯并硫代吡喃基化合物，其中n为0或1，X代表R'表示H，OH，酰氧基或NH 2，R“表示H或烷氧基或R'和R “一起形成氧代，亚甲基或羟基亚氨基，R8表示H，R 9表示H，烷基，单或多羟基烷基，芳基，芳烷基，糖残基或p等于1,2或3 ，r'和r“表示H，烷基，单羟基烷基，多羟基烷基，芳基，苄基，氨基酸或胺化糖的残基，或一起形成杂环，R 1，R 2，R 3和R 4表示H或低级烷基， R5，R6和R7表示H或甲基，或当n = 1时，R5和R7与苯环一起形成萘环（R5-R7 = -CH = CH-），所述化合物的盐以及它们的 几何和光学异构体。 这些化合物可用于药物和化妆品组合物。