发明授权
- 专利标题: Triazole antifungal agents
- 专利标题(中): 三唑抗真菌药物
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申请号: US392686申请日: 1989-08-11
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公开(公告)号: US5116844A公开(公告)日: 1992-05-26
- 发明人: Roger P. Dickinson , Kenneth Richardson
- 申请人: Roger P. Dickinson , Kenneth Richardson
- 申请人地址: NY New York
- 专利权人: Pfizer Inc.
- 当前专利权人: Pfizer Inc.
- 当前专利权人地址: NY New York
- 优先权: GBX8819308 19880813
- 主分类号: C07D401/06
- IPC分类号: C07D401/06 ; A61K31/34 ; A61K31/41 ; A61K31/4196 ; A61K31/44 ; A61K31/4427 ; A61K31/443 ; A61K31/495 ; A61K31/50 ; A61K31/53 ; A61P17/00 ; A61P31/04 ; A61P31/10 ; C07D213/02 ; C07D213/06 ; C07D213/30 ; C07D213/50 ; C07D237/08 ; C07D237/10 ; C07D237/12 ; C07D239/26 ; C07D239/30 ; C07D241/12 ; C07D249/08 ; C07D401/10 ; C07D403/06 ; C07D403/10 ; C07D405/06 ; C07D521/00
摘要:
The invention provides antifungal agents of the formula: ##STR1## and their pharmaceutically acceptable salts, wherein R is phenyl optionally substituted by 1 to 3 substituents each independently selected from halo and CF.sub.3 ;R.sup.1 is C.sub.1 -C.sub.4 alkyl;R.sup.2 is H or C.sub.1 -C.sub.4 alkyl; and"Het", which is attached to the adjacent carbon atom by a ring carbon atom, is selected from pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl and triazinyl, "Het" being optionally substituted by C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, halo, CF.sub.3, CN, NO.sub.2, NH.sub.2, --NH(C.sub.1 -C.sub.4 alkanoyl) or --NHCO.sub.2 (C.sub.1 -C.sub.4 alkyl).
公开/授权文献
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