发明授权
- 专利标题: Pyranobenzoxadiazole derivatives
- 专利标题(中): 苯并恶唑衍生物
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申请号: US726897申请日: 1991-07-08
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公开(公告)号: US5272271A公开(公告)日: 1993-12-21
- 发明人: Kiyotomo Seto , Hiroo Matsumoto , Yoshimasa Kamikawaji , Kazuhiko Ohrai , Keisuke Ohdoi , Ryozo Sakoda , Yukinori Masuda
- 申请人: Kiyotomo Seto , Hiroo Matsumoto , Yoshimasa Kamikawaji , Kazuhiko Ohrai , Keisuke Ohdoi , Ryozo Sakoda , Yukinori Masuda
- 申请人地址: JPX Tokyo
- 专利权人: Nissan Chemical Industries, Ltd.
- 当前专利权人: Nissan Chemical Industries, Ltd.
- 当前专利权人地址: JPX Tokyo
- 优先权: JPX2-182525 19900710; JPX3-120279 19910524
- 主分类号: A61K31/41
- IPC分类号: A61K31/41 ; A61P9/06 ; A61P9/08 ; A61P9/10 ; A61P9/12 ; A61P11/00 ; A61P11/08 ; A61P13/02 ; A61P15/00 ; C07D498/04 ; C07F7/18 ; C07D403/04 ; C07D271/12
摘要:
A compound of the formula (I): ##STR1## wherein X.sup.1 and X.sup.2 do not exist or represent oxygen atom; A represents OH or acyloxy group having 1 to 4 carbon atoms; B represents hydrogen atom; A and B together represent a bond; R.sup.1 and R.sup.2 represent hydrogen atom or alkyl group having 1 to 4 carbon atoms, or R.sup.1 and R.sup.2 together represent 1,2-ethylene, 1,3-propylene, 1,4-butylene or 1,5-pentylene, and these alkylene groups may be substituted by alkyl group having 1 to 4 carbon atoms; R.sup.3 represents amido group of the formula: ##STR2## wherein n, R.sup.4, R.sup.5, R.sup.6, R.sup.7. R.sup.8. R.sup.9, R.sup.10 and R.sup.11 represent specific groups, and the pharmacological acceptable salts of the compounds which can form salts have strong activity for lowering blood pressure, and process therefor and pharmaceutical use of the compounds.
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