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17 条记录 (耗时 0.042 秒)

    Pyranobenzoxadiazole derivatives
    2.
    发明授权
    Pyranobenzoxadiazole derivatives 失效
    苯并恶唑衍生物

    公开(公告)号：US4900752A

    公开(公告)日：1990-02-13

    申请号：US304641

    申请日：1989-02-01

    申请人： Kiyotomo Seto ,  Hiroo Matsumoto ,  Yoshimasa Kamikawaji ,  Kazuhiko Ohrai ,  Kyoko Nakayama ,  Ryozo Sakoda ,  Yukinori Masuda

    发明人： Kiyotomo Seto ,  Hiroo Matsumoto ,  Yoshimasa Kamikawaji ,  Kazuhiko Ohrai ,  Kyoko Nakayama ,  Ryozo Sakoda ,  Yukinori Masuda

    IPC分类号： C07D491/052 ,  A61K31/352 ,  A61K31/41 ,  A61K31/4245 ,  A61P9/02 ,  A61P9/12 ,  A61P11/06 ,  C07D20060101 ,  C07D498/04

    CPC分类号： C07D498/04

    摘要： A compounds of the formula (I): ##STR1## wherein A represents OH or OC(O)CH.sub.3-n X.sub.n, B represents hydrogen atom, or A and B together represent a bond; R.sup.1 represents hydrogen atom, R.sup.2 represents hydrogen atom, C(Z)CH.sub.3-n X.sub.n or C(Z)NHCH.sub.3-n X.sub.n or R.sup.1 and R.sup.2 together represents (CH.sub.2).sub.m, (CH.sub.2).sub.m-1 C(Z), N(R.sup.3)(CH.sub.2).sub.2 C(Z), (CH.sub.2).sub.m-2 NHC(Z) or (CH.sub.2).sub.m-2 OC(Z) in which X represents fluorine atom, chlorine atom, bromine atom, a methyl group or a methoxy group and n represents 0 or an integer of 1 to 3, Z represents oxygem atom or sulfur atom, m represents an integer of 4 or 5 and R.sup.3 represents hydrogen atom or a methyl group, and pharmacological acceptable salts of the compounds which can form salts, processes therefor and pharmaceutical use of the compounds.

    摘要翻译： 本发明包括式（I）的化合物：其中A表示OH或OC（O）CH 3 -n Xn，B表示氢原子，或A和B一起表示键; R 1表示氢原子，R 2表示氢原子，C（Z）CH 3 -n Xn或C（Z）NHCH 3 -n X n或R 1和R 2一起表示（CH 2）m， ）m-1C（Z），N（R 3）（CH 2）2 C（Z），（CH 2）m -NHHC（Z）或（CH 2）m -OOC（Z） 原子，溴原子，甲基或甲氧基，n表示0或1〜3的整数，Z表示氧原子或硫原子，m表示4或5的整数，R 3表示氢原子或 甲基和可以形成盐的化合物的药理学可接受的盐，其制备方法，化合物的药物用途和包含该化合物的组合物。

    Tricyclic benzopyrane compound
    4.
    发明授权
    Tricyclic benzopyrane compound 有权
    三环苯并吡喃化合物

    公开(公告)号：US07964623B2

    公开(公告)日：2011-06-21

    申请号：US12591353

    申请日：2009-11-17

    申请人： Kazuhiko Ohrai ,  Yukohiro Shigeta ,  Osamu Uesugi ,  Takumi Okada ,  Tomoyuki Matsuda

    发明人： Kazuhiko Ohrai ,  Yukohiro Shigeta ,  Osamu Uesugi ,  Takumi Okada ,  Tomoyuki Matsuda

    IPC分类号： A61K31/429 ,  C07D513/06

    CPC分类号： C07D513/04 ,  C07D491/04 ,  C07D515/04

    摘要： This invention relates to benzopyran derivatives of formula (I) or (II), or pharmaceutically acceptable salts thereof wherein R1 and R2 are independently of each other hydrogen atom, C1-6alkyl group or C6-14aryl group, R3 is hydrogen atom or C1-6alkylcarbonyloxy group, or together with R4 forms a bond, R4 is hydrogen atom, or together with R3 forms a bond, m is an integer of 0 to 4, n is an integer of 0 to 4, V is a single bond, CR7R8, NR9, O, S, SO or SO2, R5 is hydrogen atom or C1-6alkyl group, R6 is hydrogen atom, C1-6alkyl group, C3-8cycloalkyl group, C3-8cycloalkenyl group, amino group, C1-6alkylamino group, di-C1-6alkylamino group, C6-14arylamino group, C2-9heteroarylamino group, C6-14aryl group, C2-9heteroaryl group or C2-9heterocyclyl group, A is 5-, 6- or 7-member ring fused with benzene ring, as constituent atom of the ring, oxygen atom, nitrogen atom or sulfur atom may be contained in the number of 1 to 3 alone or in a combination thereof, the number of unsaturated bond in the ring is 1, 2 or 3 including an unsaturated bond of the benzene ring to be fused, carbon atoms constituting the ring may be carbonyl or thiocarbonyl. These compounds are useful as an anti-arrhythmic agent.

    摘要翻译： 本发明涉及式（I）或（II）的苯并吡喃衍生物或其药学上可接受的盐，其中R1和R2彼此独立地为氢原子，C1-6烷基或C6-14芳基，R3为氢原子或C1- C 1-6烷基羰基氧基或与R 4一起形成键，R 4为氢原子，或与R 3一起形成键，m为0〜4的整数，n为0〜4的整数，V为单键，CR 7 R 8， NR9，O，S，SO或SO2，R5是氢原子或C1-6烷基，R6是氢原子，C1-6烷基，C3-8环烷基，C3-8环烯基，氨基，C1-6烷基氨基， C 1-6烷基氨基，C 6-14芳基氨基，C 2-9杂芳基氨基，C 6-14芳基，C 2-9杂芳基或C 2-9杂环基，A是与苯环稠合的5-，6-或7-元环作为构成原子 的环，氧原子，氮原子或硫原子可以单独或组合1〜3的数量包含在t中的不饱和键的数量 环是1,2或3，包括待稠合的苯环的不饱和键，构成环的碳原子可以是羰基或硫代羰基。 这些化合物可用作抗心律不齐剂。

    Optically active bidentate phosphine ligand palladium complex
    5.
    发明授权
    Optically active bidentate phosphine ligand palladium complex 失效
    光活性二齿膦配体钯络合物

    公开(公告)号：US5880301A

    公开(公告)日：1999-03-09

    申请号：US894520

    申请日：1997-09-16

    申请人： Masakatsu Shibasaki ,  Mikiko Sodeoka ,  Kazuhiko Ohrai

    发明人： Masakatsu Shibasaki ,  Mikiko Sodeoka ,  Kazuhiko Ohrai

    IPC分类号： B01J31/24 ,  C07F15/00 ,  C07F9/02

    CPC分类号： B01J31/2295 ,  B01J31/2409 ,  B01J31/2414 ,  B01J31/2452 ,  C07F15/0066 ,  B01J2231/4272 ,  B01J2531/0205 ,  B01J2531/0266 ,  B01J2531/824 ,  B01J2531/842

    摘要： The present invention provides a novel optically active bidentate phosphine ligand palladium complex of formula (I) or (II) which can be used for the preparation of optically active .beta.-hydroxyketones: ##STR1## �wherein Y.sup.- represents an anion pair which may form salt; X represents ##STR2## {wherein R.sup.1 represents hydrogen atom, C.sub.1-6 alkyl group, C.sub.1-6 alkoxyl group, cyano group, nitro group, halogen atom or phenyl group, etc.; m represents 1 or 2; when m is 2, two R.sup.1 s may be same or different}; andA and B each independently represents phenyl group or cyclohexyl group {said phenyl group and cyclohexyl group each is unsubstituted or substituted by R.sup.2 (R.sup.2 has the same meaning as defined in R.sup.1)}).

    摘要翻译： PCT No.PCT / JP96 / 00418 Sec。 371日期：1997年9月16日 102（e）日期1997年9月16日PCT提交1996年2月23日PCT公布。 出版物WO96 / 26210 日期：1996年8月29日本发明提供了可用于制备光学活性β-羟基酮的式（I）或（II）的新型光学活性二齿膦配体钯络合物： （II）[其中Y-表示可形成盐的阴离子对; X代表原子，C 1-6烷基，C 1-6烷氧基，氰基，硝基，卤原子或苯基等; m表示1或2; 当m为2时，两个R1可以相同或不同}; A和B各自独立地表示苯基或环己基（所述苯基和环己基各自未被取代或被R 2取代（R 2具有与R 1中定义相同的含义）}）。

    Substituted benzopyran derivatives against arrhythmia
    7.
    发明授权
    Substituted benzopyran derivatives against arrhythmia 失效
    取代苯并吡喃衍生物抗心律失常

    公开(公告)号：US07041700B2

    公开(公告)日：2006-05-09

    申请号：US10479118

    申请日：2002-06-17

    申请人： Yoshio Ohara ,  Kazuhiko Ohrai ,  Kazufumi Yanagihara ,  Yukihiro Shigeta ,  Toru Tsukagoshi ,  Toru Yamashita

    发明人： Yoshio Ohara ,  Kazuhiko Ohrai ,  Kazufumi Yanagihara ,  Yukihiro Shigeta ,  Toru Tsukagoshi ,  Toru Yamashita

    IPC分类号： A61K31/35

    CPC分类号： C07D311/68

    摘要： This invention relates to benzopyran derivatives of the formula (1) or the formula (2) wherein R1 and R2 represent independently of each other hydrogen atom or C1-6alkyl group, R3 represents hydroxyl group or C1-6 alkylcarbonyloxy group, R4 represents hydrogen atom or C1-6 alkyl group, R5 represents C1-6 alkyl group substituted with C6-14 aryl group or heteroaryl group, R6 represents C1-6 alkyl group, C1-6 alkoxy group, halogen atom, nitro group, C(O)NH2, C(O)NHR8 or C(O)NR8R9, or pharmaceutically acceptable salts thereof. These compounds are useful as an antiarrhythmic agent

    摘要翻译： 本发明涉及式（1）或式（2）的苯并吡喃衍生物，其中R 1和R 2各自独立地表示氢原子或C 1-6个烷基，R 3表示羟基或C 1-6烷基羰基氧基，R 4表示氢原子或 C 1-6烷基，R 5表示被C 6-14烷基取代的C 1-6烷基。 芳基或杂芳基，R 6表示C 1-6烷基，C 1-6烷氧基，卤素原子，硝基， C（O）NH 2，C（O）NHR 8或C（O）NR 8 R 9， ，或其药学上可接受的盐。 这些化合物可用作抗心律失常药

    Tricyclic benzopyrane compound
    9.
    发明申请
    Tricyclic benzopyrane compound 有权
    三环苯并吡喃化合物

    公开(公告)号：US20100069374A1

    公开(公告)日：2010-03-18

    申请号：US12591353

    申请日：2009-11-17

    申请人： Kazuhiko Ohrai ,  Yukohiro Shigeta ,  Osamu Uesugi ,  Takumi Okada ,  Tomoyuki Matsuda

    发明人： Kazuhiko Ohrai ,  Yukohiro Shigeta ,  Osamu Uesugi ,  Takumi Okada ,  Tomoyuki Matsuda

    IPC分类号： A61K31/542 ,  A61K31/5383 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/436 ,  A61K31/429 ,  A61K31/424 ,  A61K31/4188 ,  A61K31/4162 ,  A61K31/407 ,  C07D513/04 ,  C07D498/04 ,  C07D491/052 ,  A61P9/06

    CPC分类号： C07D513/04 ,  C07D491/04 ,  C07D515/04

    摘要： This invention relates to benzopyran derivatives of formula (I) or (II), or pharmaceutically acceptable salts thereof wherein R1 and R2 are independently of each other hydrogen atom, C1-6alkyl group or C6-14aryl group, R3 is hydrogen atom or C1-6alkylcarbonyloxy group, or together with R4 forms a bond, R4 is hydrogen atom, or together with R3 forms a bond, m is an integer of 0 to 4, n is an integer of 0 to 4, V is a single bond, CR7R8, NR9, O, S, SO or SO2, R5 is hydrogen atom or C1-6alkyl group, R6 is hydrogen atom, C1-6alkyl group, C3-8cycloalkyl group, C3-8cycloalkenyl group, amino group, C1-6alkylamino group, di-C1-6alkylamino group, C6-14arylamino group, C2-9heteroarylamino group, C6-14aryl group, C2-9heteroaryl group or C2-9heterocyclyl group, A is 5-, 6- or 7-member ring fused with benzene ring, as constituent atom of the ring, oxygen atom, nitrogen atom or sulfur atom may be contained in the number of 1 to 3 alone or in a combination thereof, the number of unsaturated bond in the ring is 1, 2 or 3 including an unsaturated bond of the benzene ring to be fused, carbon atoms constituting the ring may be carbonyl or thiocarbonyl. These compounds are useful as an anti-arrhythmic agent.

    摘要翻译： 本发明涉及式（I）或（II）的苯并吡喃衍生物或其药学上可接受的盐，其中R1和R2彼此独立地为氢原子，C1-6烷基或C6-14芳基，R3为氢原子或C1- C 1-6烷基羰基氧基或与R 4一起形成键，R 4为氢原子，或与R 3一起形成键，m为0〜4的整数，n为0〜4的整数，V为单键，CR 7 R 8， NR9，O，S，SO或SO2，R5是氢原子或C1-6烷基，R6是氢原子，C1-6烷基，C3-8环烷基，C3-8环烯基，氨基，C1-6烷基氨基， C 1-6烷基氨基，C 6-14芳基氨基，C 2-9杂芳基氨基，C 6-14芳基，C 2-9杂芳基或C 2-9杂环基，A是与苯环稠合的5-，6-或7-元环作为构成原子 的环，氧原子，氮原子或硫原子可以单独或组合1〜3的数量包含在t中的不饱和键的数量 环是1,2或3，包括待稠合的苯环的不饱和键，构成环的碳原子可以是羰基或硫代羰基。 这些化合物可用作抗心律不齐剂。

    Tricyclic Benzopyrane Compound as Anti-Arrhythmic Agents
    10.
    发明申请
    Tricyclic Benzopyrane Compound as Anti-Arrhythmic Agents 有权
    三环苯并吡喃复合物作为抗心律不齐剂

    公开(公告)号：US20080004262A1

    公开(公告)日：2008-01-03

    申请号：US10590975

    申请日：2005-03-23

    申请人： Kazuhiko Ohrai ,  Yukohiro Shigeta ,  Osamu Uesugi ,  Takumi Okada ,  Tomoyuki Matsuda

    发明人： Kazuhiko Ohrai ,  Yukohiro Shigeta ,  Osamu Uesugi ,  Takumi Okada ,  Tomoyuki Matsuda

    IPC分类号： A61K31/436 ,  A61K31/403 ,  A61K31/495 ,  A61K31/517 ,  A61K31/538 ,  A61P9/06 ,  C07D209/56 ,  C07D221/02 ,  C07D235/02 ,  C07D241/36 ,  C07D265/38 ,  C07D515/12

    CPC分类号： C07D513/04 ,  C07D491/04 ,  C07D515/04

    摘要： This invention relates to benzopyran derivatives of formula (I) or (II), or pharmaceutically acceptable salts thereof wherein R1 and R2 are independently of each other hydrogen atom, C1-6alkyl group or C6-14aryl group, R3 is hydrogen atom or C1-6alkylcarbonyloxy group, or together with R4 forms a bond, R4 is hydrogen atom, or together with R3 forms a bond, m is an integer of 0 to 4, n is an integer of 0 to 4, V is a single bond, CR7R8, NR9, O, S, SO or SO2, R5 is hydrogen atom or C1-6alkyl group, R6 is hydrogen atom, C1-6alkyl group, C3-8cycloalkyl group, C3-8cycloalkenyl group, amino group, C1-6alkylamino group, di-C1-6alkylamino group, C6-14arylamino group, C2-9heteroarylamino group, C6-14aryl group, C2-9heteroaryl group or C2-9heterocyclyl group, A is 5-, 6- or 7-member ring fused with benzene ring, as constituent atom of the ring, oxygen atom, nitrogen atom or sulfur atom may be contained in the number of 1 to 3 alone or in a combination thereof, the number of unsaturated bond in the ring is 1, 2 or 3 including an unsaturated bond of the benzene ring to be fused, carbon atoms constituting the ring may be carbonyl or thiocarbonyl. These compounds are useful as an anti-arrhythmic agent.

    摘要翻译： 本发明涉及式（I）或（II）的苯并吡喃衍生物或其药学上可接受的盐，其中R 1和R 2彼此独立地为氢原子，C C 1-6烷基或C 6-14芳基，R 3是氢原子或C 1-6 >烷基羰氧基，或与R 4连接形成键，R 4是氢原子，或与R 3 3一起形成键，m 为0〜4的整数，n为0〜4的整数，V为单键，CR 7，R 8，NR 9， >，O，S，SO或SO 2，R 5是氢原子或C 1-6烷基，R 6 C 1-6烷基，C 3-8环烷基，C 3-8环烯基，C 3-8环烷基，C 3-6环烷基， 氨基，C 1-6烷基氨基，二-C 1-6烷基氨基，C 6-14芳基氨基，C 2-9个杂芳基氨基，C 6-14-14芳基，C 2-9 - 杂芳基 A或C 2-9杂环基，A是与苯环稠合的5-，6-或7-元环，作为环的构成原子，氧原子，氮原子或硫原子可以 单独或以其组合存在1〜3的数量，环中的不饱和键数为1,2或3，包括要被稠合的苯环的不饱和键，构成环的碳原子可以是羰基 或硫代羰基。 这些化合物可用作抗心律不齐剂。