公开(公告)号：US5955481A

公开(公告)日：1999-09-21

申请号：US18843

申请日：1998-02-04

申请人： Yoshio Ohara ,  Mikio Suzuki ,  Nobuhide Miyachi ,  Katsuhiro Kato ,  Keisuke Ohdoi ,  Tetsuya Kobayashi ,  Ken-ichi Shikada ,  Takeshi Naito ,  Takashi Yotsumoto

发明人： Yoshio Ohara ,  Mikio Suzuki ,  Nobuhide Miyachi ,  Katsuhiro Kato ,  Keisuke Ohdoi ,  Tetsuya Kobayashi ,  Ken-ichi Shikada ,  Takeshi Naito ,  Takashi Yotsumoto

IPC分类号： C07D417/06 ,  C07D417/14 ,  A61K31/42 ,  A61K31/425

CPC分类号： C07D417/06 ,  C07D417/14

摘要： The present invention provides novel pyridine type thiazolidines and their salts, expressed by the following formula (I): ##STR1##

摘要翻译： 本发明提供新的吡啶型噻唑烷及其盐，由下式（I）表示：

公开(公告)号：US5272271A

公开(公告)日：1993-12-21

申请号：US726897

申请日：1991-07-08

申请人： Kiyotomo Seto ,  Hiroo Matsumoto ,  Yoshimasa Kamikawaji ,  Kazuhiko Ohrai ,  Keisuke Ohdoi ,  Ryozo Sakoda ,  Yukinori Masuda

发明人： Kiyotomo Seto ,  Hiroo Matsumoto ,  Yoshimasa Kamikawaji ,  Kazuhiko Ohrai ,  Keisuke Ohdoi ,  Ryozo Sakoda ,  Yukinori Masuda

IPC分类号： A61K31/41 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  A61P11/00 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  C07D498/04 ,  C07F7/18 ,  C07D403/04 ,  C07D271/12

CPC分类号： C07D498/04 ,  C07F7/1856

摘要： A compound of the formula (I): ##STR1## wherein X.sup.1 and X.sup.2 do not exist or represent oxygen atom; A represents OH or acyloxy group having 1 to 4 carbon atoms; B represents hydrogen atom; A and B together represent a bond; R.sup.1 and R.sup.2 represent hydrogen atom or alkyl group having 1 to 4 carbon atoms, or R.sup.1 and R.sup.2 together represent 1,2-ethylene, 1,3-propylene, 1,4-butylene or 1,5-pentylene, and these alkylene groups may be substituted by alkyl group having 1 to 4 carbon atoms; R.sup.3 represents amido group of the formula: ##STR2## wherein n, R.sup.4, R.sup.5, R.sup.6, R.sup.7. R.sup.8. R.sup.9, R.sup.10 and R.sup.11 represent specific groups, and the pharmacological acceptable salts of the compounds which can form salts have strong activity for lowering blood pressure, and process therefor and pharmaceutical use of the compounds.