发明授权
US5382579A Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals
失效
三氮唑-1,4-二氮杂衍生物及其在药物中的应用
- 专利标题： Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals
- 专利标题（中）： 三氮唑-1,4-二氮杂衍生物及其在药物中的应用
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申请号： US751632申请日： 1991-08-26
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公开(公告)号： US5382579A公开(公告)日： 1995-01-17
- 发明人: Kazuo Okano , Shuhei Miyazawa , Richard S. J. Clark , Shinya Abe , Tetsuya Kawahara , Naoyuki Shimomura , Osamu Asano , Hiroyuki Yoshimura , Mitsuaki Miyamoto , Yoshimori Sakuma , Kenzo Muramoto , Hiroshi Obaishi , Koukichi Harada , Hajime Tsunoda , Satoshi Katayama , Kouji Yamada , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
- 申请人： Kazuo Okano , Shuhei Miyazawa , Richard S. J. Clark , Shinya Abe , Tetsuya Kawahara , Naoyuki Shimomura , Osamu Asano , Hiroyuki Yoshimura , Mitsuaki Miyamoto , Yoshimori Sakuma , Kenzo Muramoto , Hiroshi Obaishi , Koukichi Harada , Hajime Tsunoda , Satoshi Katayama , Kouji Yamada , Shigeru Souda , Yoshimasa Machida , Kouichi Katayama , Isao Yamatsu
- 申请人地址： JPX Tokyo
- 专利权人： Eisai Co., Ltd.
- 当前专利权人： Eisai Co., Ltd.
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX63-275460 19881031; JPX63-297068 19881124; JPX63-318016 19881216; JPX63-331622 19881228
- 主分类号： C07D495/14
- IPC分类号： C07D495/14 ; C07D495/22 ; C07F9/6561 ; A61K31/55
摘要：
A triazolo-1,4-azepine compound of the below given formulas and a pharmacologically acceptable salt thereof are disclosed and useful in the pharmaceutical field, especially to allergic diseases. ##STR1## in which R1 and R2 are hydrogen or an alkyl, R3 is hydrogen or a halogen, R4 is hydrogen or an alkyl, X is --OCO--, --NHCO--, --CO-- or others and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.