发明授权
- 专利标题： Guanidine derivatives
- 专利标题（中）： 胍衍生物
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申请号： US77476申请日： 1993-06-15
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公开(公告)号： US5393760A公开(公告)日： 1995-02-28
- 发明人: Jean Ackermann , David Banner , Klaus Gubernator , Paul Hadvary , Kurt Hilpert , Klaus Muller , Ludvik Labler , Gerard Schmid , Thomas B. Tschopp , Hans P. Wessel , Beat Wirz
- 申请人： Jean Ackermann , David Banner , Klaus Gubernator , Paul Hadvary , Kurt Hilpert , Klaus Muller , Ludvik Labler , Gerard Schmid , Thomas B. Tschopp , Hans P. Wessel , Beat Wirz
- 申请人地址： NJ Nutley
- 专利权人： Hoffmann-La Roche Inc.
- 当前专利权人： Hoffmann-La Roche Inc.
- 当前专利权人地址： NJ Nutley
- 优先权： CHX2250/90 19900705; CHX1315/91 19910502
- 主分类号： A61K31/445
- IPC分类号： A61K31/445 ; A61K31/4427 ; A61K31/4433 ; A61K31/47 ; A61K31/535 ; A61K31/5375 ; A61K31/55 ; A61P7/02 ; A61P35/00 ; C07D20060101 ; C07D211/20 ; C07D211/22 ; C07D211/26 ; C07D211/60 ; C07D265/30 ; C07D265/32 ; C07D401/12 ; C07D401/14 ; C07D409/12 ; C07D409/14 ; C07D413/12
摘要：
Compounds of the formula ##STR1## wherein L, M, R, T and X are set forth in the description, as well as hydrates or solvates thereof, which inhibit thrombin-induced platelet aggregation and clotting of fibrinogen in plasma, are described. The compounds of formula I are prepared by amidination or, depending on whether L is NH or O, by amide formation or esterification.