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公开(公告)号：US5532232A
公开(公告)日：1996-07-02
申请号：US343168
申请日：1994-11-22
申请人： Jean Ackermann , David Banner , Klaus Gubernator , Paul Hadvary , Kurt Hilpert , Klaus Muller , Ludvik Labler , Gerard Schmid , Thomas B. Tschopp , Hans P. Wessel , Beat Wirz
发明人： Jean Ackermann , David Banner , Klaus Gubernator , Paul Hadvary , Kurt Hilpert , Klaus Muller , Ludvik Labler , Gerard Schmid , Thomas B. Tschopp , Hans P. Wessel , Beat Wirz
IPC分类号： A61K31/445 , A61K31/4427 , A61K31/4433 , A61K31/47 , A61K31/535 , A61K31/5375 , A61K31/55 , A61P7/02 , A61P35/00 , C07D20060101 , C07D211/20 , C07D211/22 , C07D211/26 , C07D211/60 , C07D265/30 , C07D265/32 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/14 , C07D413/12
CPC分类号： C07D265/30 , C07D211/22 , C07D211/26 , C07D211/60 , C07D265/32 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , Y10S514/822
摘要： Compounds of the formula ##STR1## wherein L, M, R, T and X are set forth in the description, as well as hydrates or solvates thereof, which inhibit thrombin-induced platelet aggregation and clotting of fibrinogen in plasma, are described. The compounds of formula I are prepared by amidination or, depending on whether L is NH or O, by amide formation or esterification.
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公开(公告)号：US5393760A
公开(公告)日：1995-02-28
申请号：US77476
申请日：1993-06-15
申请人： Jean Ackermann , David Banner , Klaus Gubernator , Paul Hadvary , Kurt Hilpert , Klaus Muller , Ludvik Labler , Gerard Schmid , Thomas B. Tschopp , Hans P. Wessel , Beat Wirz
发明人： Jean Ackermann , David Banner , Klaus Gubernator , Paul Hadvary , Kurt Hilpert , Klaus Muller , Ludvik Labler , Gerard Schmid , Thomas B. Tschopp , Hans P. Wessel , Beat Wirz
IPC分类号： A61K31/445 , A61K31/4427 , A61K31/4433 , A61K31/47 , A61K31/535 , A61K31/5375 , A61K31/55 , A61P7/02 , A61P35/00 , C07D20060101 , C07D211/20 , C07D211/22 , C07D211/26 , C07D211/60 , C07D265/30 , C07D265/32 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/14 , C07D413/12
CPC分类号： C07D265/30 , C07D211/22 , C07D211/26 , C07D211/60 , C07D265/32 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , Y10S514/822
摘要： Compounds of the formula ##STR1## wherein L, M, R, T and X are set forth in the description, as well as hydrates or solvates thereof, which inhibit thrombin-induced platelet aggregation and clotting of fibrinogen in plasma, are described. The compounds of formula I are prepared by amidination or, depending on whether L is NH or O, by amide formation or esterification.
摘要翻译： 描述了其描述中描述的L，M，R，T和X以及其中抑制凝血酶诱导的血小板聚集和血浆中纤维蛋白原凝血的水合物或溶剂化物的式ⅠA化合物。 式I的化合物通过酰胺化或通过酰胺形成或酯化作用取决于L是NH或O来制备。
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公开(公告)号：US5260307A
公开(公告)日：1993-11-09
申请号：US719429
申请日：1991-06-24
申请人： Jean Ackermann , David Banner , Klaus Gubernator , Paul Hadvary , Kurt Hilpert , Klaus Muller , Ludvik Labler , Gerard Schmid , Thomas B. Tschopp , Hans P. Wessel , Beat Wirz
发明人： Jean Ackermann , David Banner , Klaus Gubernator , Paul Hadvary , Kurt Hilpert , Klaus Muller , Ludvik Labler , Gerard Schmid , Thomas B. Tschopp , Hans P. Wessel , Beat Wirz
IPC分类号： A61K31/445 , A61K31/4427 , A61K31/4433 , A61K31/47 , A61K31/535 , A61K31/5375 , A61K31/55 , A61P7/02 , A61P35/00 , C07D20060101 , C07D211/20 , C07D211/22 , C07D211/26 , C07D211/60 , C07D265/30 , C07D265/32 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/14 , C07D413/12
CPC分类号： C07D265/30 , C07D211/22 , C07D211/26 , C07D211/60 , C07D265/32 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , Y10S514/822
摘要： Compounds of the formula ##STR1## wherein L, M, R, T and X are set forth in the description, as well as hydrates or solvates thereof, which inhibit thrombin-induced platelet aggregation and clotting of fibrinogen in plasma, are described. The compounds of formula I are prepared by amidination or, depending on whether L is NH or O, by amide formation or esterification.
摘要翻译： 描述了其描述中描述的L，M，R，T和X以及其中抑制凝血酶诱导的血小板聚集和血浆中纤维蛋白原凝血的水合物或溶剂化物的式ⅠA化合物。 式I的化合物通过酰胺化或通过酰胺形成或酯化作用取决于L是NH或O来制备。
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公开(公告)号：US5763436A
公开(公告)日：1998-06-09
申请号：US715038
申请日：1996-09-17
申请人： Jean Ackermann , David Banner , Klaus Gubernator , Paul Hadvary , Kurt Hilpert , Klaus Muller , Ludvik Labler , Gerard Schmid , Thomas B. Tschopp , Hans Peter Wessel , Beat Wirz
发明人： Jean Ackermann , David Banner , Klaus Gubernator , Paul Hadvary , Kurt Hilpert , Klaus Muller , Ludvik Labler , Gerard Schmid , Thomas B. Tschopp , Hans Peter Wessel , Beat Wirz
IPC分类号： A61K31/445 , A61K31/4427 , A61K31/4433 , A61K31/47 , A61K31/535 , A61K31/5375 , A61K31/55 , A61P7/02 , A61P35/00 , C07D20060101 , C07D211/20 , C07D211/22 , C07D211/26 , C07D211/60 , C07D265/30 , C07D265/32 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D267/10
CPC分类号： C07D265/30 , C07D211/22 , C07D211/26 , C07D211/60 , C07D265/32 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , Y10S514/822
摘要： Compounds of the formula ##STR1## wherein L, M, R, T and X are set forth in the description, as well as hydrates or solvates thereof, which inhibit thrombin-induced platelet aggregation and clotting of fibrinogen in plasma, are described. The compounds of formula I are prepared by amidination or, depending on whether L is NH or O, by amide formation or esterification.
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公开(公告)号：US5595999A
公开(公告)日：1997-01-21
申请号：US473060
申请日：1995-06-07
申请人： Jean Ackermann , David Banner , Klaus Gubernator , Paul Hadvary , Kurt Hilpert , Klaus M uller , Ludvik Labler , G erard Schmid , Thomas B. Tschopp , Hans P. Wessel , Beat Wirz
发明人： Jean Ackermann , David Banner , Klaus Gubernator , Paul Hadvary , Kurt Hilpert , Klaus M uller , Ludvik Labler , G erard Schmid , Thomas B. Tschopp , Hans P. Wessel , Beat Wirz
IPC分类号： A61K31/445 , A61K31/4427 , A61K31/4433 , A61K31/47 , A61K31/535 , A61K31/5375 , A61K31/55 , A61P7/02 , A61P35/00 , C07D20060101 , C07D211/20 , C07D211/22 , C07D211/26 , C07D211/60 , C07D265/30 , C07D265/32 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/14 , C07D413/12
CPC分类号： C07D265/30 , C07D211/22 , C07D211/26 , C07D211/60 , C07D265/32 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , Y10S514/822
摘要： Compounds of the formula ##STR1## wherein L, M, R, T and X are set forth in the description, as well as hydrates or solvates thereof, which inhibit thrombin-induced platelet aggregation and clotting of fibrinogen in plasma, are described. The compounds of formula I are prepared by amidination or, depending on whether L is NH or O, by amide formation or esterification.
摘要翻译： 描述了其描述中描述的L，M，R，T和X以及其中抑制凝血酶诱导的血小板聚集和血浆中纤维蛋白原凝血的水合物或溶剂化物的式ⅠA化合物。 式I的化合物通过酰胺化或通过酰胺形成或酯化作用取决于L是NH或O来制备。
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公开(公告)号：US5583133A
公开(公告)日：1996-12-10
申请号：US511428
申请日：1995-08-04
申请人： Jean Ackermann , David Banner , Klaus Gubernator , Paul Hadvary , Kurt Hilpert , Klaus M uller , Ludvik Labler , G erard Schmid , Thomas B. Tschopp , Hans P. Wessel , Beat Wirz
发明人： Jean Ackermann , David Banner , Klaus Gubernator , Paul Hadvary , Kurt Hilpert , Klaus M uller , Ludvik Labler , G erard Schmid , Thomas B. Tschopp , Hans P. Wessel , Beat Wirz
IPC分类号： A61K31/445 , A61K31/4427 , A61K31/4433 , A61K31/47 , A61K31/535 , A61K31/5375 , A61K31/55 , A61P7/02 , A61P35/00 , C07D20060101 , C07D211/20 , C07D211/22 , C07D211/26 , C07D211/60 , C07D265/30 , C07D265/32 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/14 , C07D413/12
CPC分类号： C07D265/30 , C07D211/22 , C07D211/26 , C07D211/60 , C07D265/32 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , Y10S514/822
摘要： Compounds of the formula ##STR1## wherein L, M, R, T and X are set forth in the description, as well as hydrates or solvates thereof, which inhibit thrombin-induced platelet aggregation and clotting of fibrinogen in plasma, are described. The compounds of formula I are prepared by amidination or, depending on whether L is NH or O, by amide formation or esterification.
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