发明授权
- 专利标题： Synthesis of compounds with predetermined chirality
- 专利标题（中）： 合成具有预定手性的化合物
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申请号： US216926申请日： 1994-03-23
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公开(公告)号： US5488131A公开(公告)日： 1996-01-30
- 发明人: Andrew G. Myers
- 申请人： Andrew G. Myers
- 专利权人： California Institute of Technology
- 当前专利权人： California Institute of Technology
- 主分类号： C07D521/00
- IPC分类号： C07D521/00 ; B01J31/02 ; C07B53/00 ; C07C29/00 ; C07C29/147 ; C07C31/10 ; C07C31/125 ; C07C33/18 ; C07C33/34 ; C07C45/41 ; C07C45/45 ; C07C45/67 ; C07C47/02 ; C07C47/228 ; C07C49/04 ; C07C49/213 ; C07C49/76 ; C07C49/782 ; C07C51/06 ; C07C53/126 ; C07C57/30 ; C07C227/18 ; C07C227/32 ; C07C231/12 ; C07C231/18 ; C07C233/17 ; C07C233/18 ; C07C233/22 ; C07C235/02 ; C07C235/34 ; C07C237/06 ; C07C237/16 ; C07C271/22 ; C07F7/18 ; C07F9/50 ; C07C271/00 ; C07C233/04
摘要：
A method for synthesizing enantiomerically enriched chemical intermediates with predetermined chirality is described. The method comprises formation of a pseudoephedrine amide, followed by stereoselective alkylation at the alpha carbon. The chiral auxiliary can then be cleaved off, affording chiral end products useful for further transformations. The enantiomeric enrichment of the chiral end products may exceed 98%, and the chiral auxiliary can be recovered. Novel amides of pseudoephedrine used in this method are also disclosed.
公开/授权文献
- US4876132A Method and apparatus for installing automobile glazing 公开/授权日：1989-10-24
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