- 专利标题： Systematic evolution of ligands by exponential enrichment: tissue selex
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申请号： US434001申请日： 1995-05-03
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公开(公告)号： US5712375A公开(公告)日： 1998-01-27
- 发明人: Kirk B. Jensen , Hang Chen , Kevin N. Morris , Andrew Stephens , Larry Gold
- 申请人： Kirk B. Jensen , Hang Chen , Kevin N. Morris , Andrew Stephens , Larry Gold
- 申请人地址： CO Boulder
- 专利权人： NeXstar Pharmaceuticals, Inc.
- 当前专利权人： NeXstar Pharmaceuticals, Inc.
- 当前专利权人地址： CO Boulder
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07B61/00 ; C07H19/06 ; C07H19/10 ; C07H21/00 ; C07K7/22 ; C07K14/00 ; C07K14/16 ; C07K14/72 ; C12N9/12 ; C12N15/10 ; C12N15/115 ; C12Q1/37 ; C12Q1/68 ; C12Q1/70 ; F02B75/02 ; G01N33/53 ; G01N33/531 ; G01N33/532 ; G01N33/535 ; G01N33/569 ; G01N33/68 ; G01N33/76 ; C07K1/14 ; C07H21/04 ; C12P19/34
摘要：
This invention discloses high-affinity oligonucleotide ligands to complex tissue targets, specifically nucleic acid ligands having the ability to bind to complex tissue targets, and the methods for obtaining such ligands. Tissue targets comprise cells, subcellular components, aggregates or cells, collections of cells, and higher ordered structures. Specifically, nucleic acid ligands to red blood cells ghosts, glioblastomas, and lymphomas are described.
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