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    COMPOUNDS AS APTAMER-DIMERS AND THEIR USES IN DIAGNOSIS AND THERAPY
    1.
    发明申请
    COMPOUNDS AS APTAMER-DIMERS AND THEIR USES IN DIAGNOSIS AND THERAPY 审中-公开
    化合物作为APTAMER-DIMERS及其在诊断和治疗中的用途

    公开(公告)号：US20080207523A1

    公开(公告)日：2008-08-28

    申请号：US11851789

    申请日：2007-09-07

    申请人： Matthias Friebe ,  Andrew Stephens ,  Ananth Srinivasan ,  Maren Hecht

    发明人： Matthias Friebe ,  Andrew Stephens ,  Ananth Srinivasan ,  Maren Hecht

    IPC分类号： A61K38/08 ,  C07K7/06 ,  A61P35/00 ,  C07K1/00

    CPC分类号： C07K14/001 ,  A61K38/00 ,  A61K47/65 ,  A61K51/088 ,  C07K7/02

    摘要： The object of the present invention is solved by compositions of peptide linkers and their use for synthesis and annealing of aptamer oligonucleotides in form of dimers. The present invention in particularly provides said compositions for the use as a diagnostic and/or therapeutic agent.In another preferred embodiment the present invention relates to a kit for preparing a radiopharmaceutical preparation, said kit comprising a vial comprising a quantity of the compound according to the invention.A further preferred embodiment of the present invention relates to methods of producing said compounds, comprising synthesis of said compound in an automated peptide synthesizer.In another preferred embodiment the present invention concerns the use of said compounds according to the present invention for the manufacture of a medicament, preferably for diagnosis or therapy of proliferative diseases.In a further preferred embodiment the present invention concerns methods for treating or diagnosing patients administering or utilizing the compounds according to the present invention.

    摘要翻译： 本发明的目的是通过肽接头的组合物及其用于以二聚体的形式合成和退火适体寡核苷酸的用途来解决的。 本发明特别提供了用作诊断和/或治疗剂的所述组合物。 在另一个优选的实施方案中，本发明涉及一种用于制备放射性药物制剂的试剂盒，所述试剂盒包含一定量的包含本发明化合物的小瓶。 本发明的另一优选实施方案涉及生产所述化合物的方法，包括在自动肽合成仪中合成所述化合物。 在另一个优选的实施方案中，本发明涉及根据本发明的所述化合物在制备药物中的用途，优选用于诊断或治疗增殖性疾病。 在另一优选实施方案中，本发明涉及用于治疗或诊断施用或使用本发明化合物的患者的方法。

    Facsimile distribution manager
    5.
    发明授权
    Facsimile distribution manager 失效
    传真经销经理

    公开(公告)号：US06897971B1

    公开(公告)日：2005-05-24

    申请号：US09328622

    申请日：1999-06-09

    申请人： Keith Alan Marshall ,  Mark Andrew Stephens

    发明人： Keith Alan Marshall ,  Mark Andrew Stephens

    IPC分类号： G06K1/00 ,  H04N1/00 ,  H04N1/32 ,  H04N1/407

    CPC分类号： H04N1/32411 ,  H04N1/32037 ,  H04N1/324 ,  H04N1/32416 ,  H04N1/407

    摘要： A method, apparatus, article of manufacture, and a memory structure for electronically distributing facsimile messages directly to users according to recipient preferences. The method comprises the steps of receiving a message from a transmitting facsimile via a telephone network, automatically parsing the message to extract a recipient direct dial telephone number from the message, receiving a fax payload from the transmitting facsimile in a fax server, determining an e-mail address and at least one recipient fax preference from the direct dial telephone number, processing the fax payload in the fax server according to the recipient fax preference, and directing the processed fax message according to the recipient fax preference. In one embodiment of the present invention, method further comprises the steps of reading a grayscale transform from a memory accessible to the fax server, and applying the grayscale transform to the fax payload. This allows the facsimile to be presented to the user with improved grayscale rendering accuracy. In another embodiment of the present invention, recipient's direct dial telephone number is extracted using the direct inward dial facility of a facsimile card, thus providing a simple straightforward means for determining the identity of the intended recipient. In another embodiment of the present invention, the e-mail address of the intended recipient is obtained from an address lookup facility of a messaging and collaboration application. The apparatus comprises means for performing the foregoing steps, and the article of manufacture comprises a program storage device tangibly embodying instructions for performing these steps.

    摘要翻译： 一种方法，装置，制品和用于根据接收者偏好将传真消息直接电子分发给用户的存储结构。 该方法包括以下步骤：经由电话网络从发送传真接收消息，自动解析消息以从消息中提取接收者直拨电话号码，从传真服务器中的传真传真接收传真有效载荷，确定e 邮件地址和来自直拨电话号码的至少一个收件人传真优先权，根据接收者传真优先处理传真服务器中的传真有效载荷，以及根据接收者传真优先级指示处理的传真消息。 在本发明的一个实施例中，方法还包括从传真服务器可访问的存储器读取灰阶变换以及将灰阶变换应用于传真有效载荷的步骤。 这允许以更好的灰度渲染精度将传真呈现给用户。 在本发明的另一个实施例中，使用传真卡的直接向内拨号设备提取接收者的直拨电话号码，从而提供用于确定预期接收者的身份的简单直接手段。 在本发明的另一个实施例中，从消息和协作应用的地址查找设备获得预期接收者的电子邮件地址。 该装置包括用于执行上述步骤的装置，并且该制品包括有形地体现用于执行这些步骤的指令的程序存储装置。

    Visual indexing of displayable digital documents
    6.
    发明授权
    Visual indexing of displayable digital documents 有权
    可视化索引显示数字文档

    公开(公告)号：US06678699B2

    公开(公告)日：2004-01-13

    申请号：US09973353

    申请日：2001-10-09

    申请人： Mark Andrew Stephens ,  Debra Kathleen Wagner

    发明人： Mark Andrew Stephens ,  Debra Kathleen Wagner

    IPC分类号： G06F1730

    CPC分类号： G06F17/30011 ,  Y10S707/99945 ,  Y10S707/99948

    摘要： A displayable digital document such as a .PDF document is indexed by displaying it on a viewer. A database field is provided in a relational database. A user selects a field in the digital document for indexing using a pointing device and defines a bounding rectangle for this field. Offsets are recorded and compared to other bounding rectangles. Comparisons are recorded in a parameter file for each document. An indexer is run to insert the offsets and other data into the relational database and also store the digital image in the relational database. A query is made of the database and part or all of the digital document is displayed based on the results of the query.

    摘要翻译： 可显示的数字文档，例如.PDF文档，通过在查看器上显示来索引。 关系数据库中提供了一个数据库字段。 用户使用定点设备选择数字文档中的字段进行索引，并定义该字段的边界矩形。 记录偏移量并与其他边界矩形进行比较。 比较记录在每个文档的参数文件中。 运行索引器将偏移量和其他数据插入到关系数据库中，并将数字图像存储在关系数据库中。 查询数据库，并根据查询结果显示部分或全部数字文档。

    Method and apparatus for rendering grayscales at a facsimile presentation device using a calibrated threshold matrix
    7.
    发明授权
    Method and apparatus for rendering grayscales at a facsimile presentation device using a calibrated threshold matrix 有权
    在使用校准的阈值矩阵的传真呈现装置上渲染灰度的方法和装置

    公开(公告)号：US06498661B1

    公开(公告)日：2002-12-24

    申请号：US09277056

    申请日：1999-03-26

    申请人： Craig Duray Brossman ,  Arianne Therese Hinds ,  Nenad Rijavec ,  Mikel J. Stanich ,  Mark Andrew Stephens ,  Raymond Glenn Wardell

    发明人： Craig Duray Brossman ,  Arianne Therese Hinds ,  Nenad Rijavec ,  Mikel J. Stanich ,  Mark Andrew Stephens ,  Raymond Glenn Wardell

    IPC分类号： G06K1502

    CPC分类号： H04N1/4058 ,  H04N1/32 ,  H04N1/4078

    摘要： A method, apparatus, article of manufacture for transmitting data to a facsimile presentation device is disclosed. In one embodiment of the invention, the method comprises the steps of receiving a presentation job comprising input data associable with at least one input grayscale value, retrieving at least one of a plurality of threshold matrices, each threshold matrix selected to control a grayscale rendering characteristic of the facsimile presentation device associated with the threshold matrix, applying the grayscale values to the retrieved threshold matrix to rasterize the input data, and transmitting the rasterized input data to the facsimile presentation device. This invention can be practiced in several embodiments, and permits the user to select the threshold matrix according to the presentation device and/or a selected presentation quality. In another embodiment of the invention, the apparatus comprises a means for receiving a presentation job having input data associable with at least one input grayscale value, means for retrieving at least one of a plurality of threshold matrices, each threshold matrix selected to control a grayscale rendering characteristic of the facsimile presentation device associated with the threshold matrix, means for applying the grayscale values to the retrieved threshold matrix to rasterize the input data, and means for transmitting the rasterized input data to the facsimile presentation device.

    摘要翻译： 公开了一种用于向传真呈现装置发送数据的方法，装置，制品。 在本发明的一个实施例中，该方法包括以下步骤：接收包括与至少一个输入灰度值相关联的输入数据的呈现作业，检索多个阈值矩阵中的至少一个，所选择的每个阈值矩阵以控制灰度渲染特性 与所述阈值矩阵相关联的所述传真呈现设备，将所述灰度值应用于所检索的阈值矩阵，以对所述输入数据进行光栅化，以及将所述光栅化输入数据发送到所述传真呈现设备。 本发明可以在几个实施例中实现，并且允许用户根据呈现设备和/或选择的呈现质量来选择阈值矩阵。 在本发明的另一个实施例中，该装置包括用于接收具有与至少一个输入灰阶值相关联的输入数据的呈现作业的装置，用于检索多个阈值矩阵中的至少一个的装置，所选择的每个阈值矩阵以控制灰度 与阈值矩阵相关联的传真呈现设备的呈现特性，用于将灰度值应用于检索到的阈值矩阵以光栅化输入数据的装置，以及用于将光栅化输入数据发送到传真呈现设备的装置。