发明授权
US5780585A Bacterial nitroreductase for the reduction of CB 1954 and analogues
thereof to a cytotoxic form
失效
用于将CB 1954及其类似物还原成细胞毒性形式的细菌硝基还原酶
- 专利标题： Bacterial nitroreductase for the reduction of CB 1954 and analogues thereof to a cytotoxic form
- 专利标题（中）： 用于将CB 1954及其类似物还原成细胞毒性形式的细菌硝基还原酶
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申请号： US504047申请日： 1995-06-07
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公开(公告)号： US5780585A公开(公告)日： 1998-07-14
- 发明人: Gillian Anlezark , Roger Melton , Roger Sherwood , Thomas Connors , Frank Friedlos , Michael Jarman , Richard Knox , Anthony Mauger , Caroline Joy Springer
- 申请人： Gillian Anlezark , Roger Melton , Roger Sherwood , Thomas Connors , Frank Friedlos , Michael Jarman , Richard Knox , Anthony Mauger , Caroline Joy Springer
- 申请人地址： GB2 London
- 专利权人： Cancer Research Campaign Technology Limited
- 当前专利权人： Cancer Research Campaign Technology Limited
- 当前专利权人地址： GB2 London
- 优先权： GBX9122464 19911023; GBX9122496 19911023
- 主分类号： C12N9/12
- IPC分类号： C12N9/12 ; A61K38/00 ; C07C219/34 ; C07C271/18 ; C07D203/14 ; C07D487/14 ; C07H15/252 ; C07H19/048 ; C07K7/06 ; C12N9/02 ; C12N15/00 ; C12N15/09 ; C12N15/53 ; C12P17/10 ; C12P21/08 ; C12R1/01 ; C12R1/07 ; C12R1/19 ; G01N33/53 ; G01N33/573 ; C07K7/56 ; C07C68/00 ; C07C69/96 ; C07C269/04 ; C07C271/28 ; C07H15/24
摘要：
A prodrug of the formula (I): ##STR1## where R.sup.1 is a group such that the compound R--NH.sub.2 represents actinomycin D, doxorubicin, mitomycin C, or a nitrogen mustard of the formula (IV): ##STR2## a prodrug of the formula (II): ##STR3## where R.sup.1 is a group such that the compound R.sup.2 OH is a phenolic nitrogen mustard; and processes whereby the prodrugs shown above are made in which a prodrug precursor compound is reacted with 4-nitrobenzyl chloroformate under anhydrous conditions.
公开/授权文献
- US4038956A Fluid pressure regulator 公开/授权日：1977-08-02
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