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    Funtionalised metallocenes as anticancer drugs
    2.
    发明申请
    Funtionalised metallocenes as anticancer drugs 审中-公开
    功能金属茂作为抗癌药物

    公开(公告)号：US20060106005A1

    公开(公告)日：2006-05-18

    申请号：US10520477

    申请日：2003-07-04

    申请人： Patrick McGowan ,  Richard Knox

    发明人： Patrick McGowan ,  Richard Knox

    IPC分类号： A61K31/555 ,  C07F17/00

    CPC分类号： C07F17/00

    摘要： The invention provides metallocene compounds of formula 1 for use as medicaments in the treatment of cancer. wherein R1, R2, R3 and R4 represent a combination of H, alkyl, aryl or trimethylsilyl; L represents side chain substituents, at least one of which contains a group which enables the compound to become water-solubilised; X is halo, alkoxy, acetate or H2O; Y is a counter-ion; M is a metal; and n=1 or 2. The invention also provides novel compounds of the formula 1 wherein at least one of the groups L comprises a quaternary tetraalkylammonium group. The compounds have been shown to have significantly greater activity in the treatment of cancer than the compounds known from the prior art.

    摘要翻译： 本发明提供式1的金属茂化合物，用作治疗癌症的药物。 其中R 1，R 2，R 3和R 4代表H，烷基，芳基或 三甲基甲硅烷基 L表示侧链取代基，其中至少一个含有使化合物变得水溶性的基团; X是卤素，烷氧基，乙酸酯或H 2 O; Y是抗衡离子; M是金属; 并且n = 1或2.本发明还提供式1的新化合物，其中基团L中的至少一个包含季铵四烷基铵基团。 已经表明，化合物在治疗癌症方面具有比现有技术已知的化合物显着更大的活性。

    System and method for cathodic protection of a subsea well-assembly
    3.
    发明授权
    System and method for cathodic protection of a subsea well-assembly 有权
    海底井组件阴极保护的系统和方法

    公开(公告)号：US08607878B2

    公开(公告)日：2013-12-17

    申请号：US12974164

    申请日：2010-12-21

    申请人： Richard Knox

    发明人： Richard Knox

    IPC分类号： E21B43/01 ,  C23F13/00

    CPC分类号： E21B41/0007 ,  C23F13/04 ,  C23F2213/21 ,  C23F2213/31 ,  E21B33/0355

    摘要： Disclosed herein is a subsea well assembly; wherein in an example embodiment the subsea well assembly includes an umbilical attached to a power source. The power source can be on a platform. Also included is a connector for connecting the umbilical to a receptacle included with the subsea well assembly and a subsea control module delivering power and control signals to the subsea well assembly. An impressed current protection module is integrated in the subsea control module that receives power from the umbilical.

    摘要翻译： 本文公开了一种海底井组件; 其中在示例性实施例中，海底井组件包括附接到动力源的脐带。 电源可以在平台上。 还包括用于将脐带连接到包括在海底井组件中的插座的连接器以及向海底井组件传送动力和控制信号的海底控制模块。 在海底控制模块中集成了一个外露电流保护模块，从而接收来自脐带的电力。

    LIQUIDAMBAR DERIVED CLEANERS
    6.
    发明申请
    LIQUIDAMBAR DERIVED CLEANERS 审中-公开
    液体衍生清洁剂

    公开(公告)号：US20150335032A1

    公开(公告)日：2015-11-26

    申请号：US14283861

    申请日：2014-05-21

    申请人： G. Richard Knox, JR.

    发明人： G. Richard Knox, JR.

    IPC分类号： A01N65/08 ,  A61K8/97 ,  A61L9/14 ,  A61Q11/00 ,  A61Q5/02 ,  A61Q19/10 ,  A61K36/185 ,  C11D1/00

    CPC分类号： A01N65/08 ,  A61K8/97 ,  A61K8/9789 ,  A61K36/185 ,  A61K2800/10 ,  A61L9/14 ,  A61Q5/02 ,  A61Q11/00 ,  A61Q19/10 ,  C11D1/00 ,  C11D3/382 ,  C11D7/44

    摘要： The present invention is a surfactant(s) for use as a cleaner and freshener as well as methods for the production/use of such surfactants/cleaners/fresheners. The surfactant is produced using and relying upon properties of the Liquidambar tree, particularly the Liquidambar leaf, by creating a liquid solution useful for cleaning and freshening purposes by soaking or steeping the leaves of Liquidambar in a solvent, preferably water. The solutions formed have been found to be effective for general cleaning and freshening purposes including, but not limited to, all known household cleaning/freshening purposes as well as for personal bodily cleaning/freshening purposes including, but not limited to, body washing, hair washing, tooth brushing, mouth washing, and the like. It is non-allergenic, non-toxic, and will cause no adverse environmental effects.

    摘要翻译： 本发明是用作清洁剂和清新剂的表面活性剂以及用于生产/使用这种表面活性剂/清洁剂/清新剂的方法。 使用并依赖于枫香树，特别是枫香叶的性质，通过在溶剂，优选水中浸泡或浸泡Liquidambar的叶子，产生用于清洁和清新目的的液体溶液来制备表面活性剂。 已经发现所形成的溶液对于一般的清洁和清新目的是有效的，包括但不限于所有已知的家用清洁/清新目的以及个人身体清洁/清新目的，包括但不限于身体清洗，头发 洗涤，牙齿刷洗，漱口等。 不过敏，无毒，不会对环境造成不良影响。

    Bacterial nitroreductase gene-prodrug system
    7.
    发明授权
    Bacterial nitroreductase gene-prodrug system 失效
    细菌硝基还原酶基因前体药物系统

    公开(公告)号：US5958682A

    公开(公告)日：1999-09-28

    申请号：US640808

    申请日：1996-07-01

    申请人： Thomas Connors ,  Richard Knox ,  Roger Sherwood

    发明人： Thomas Connors ,  Richard Knox ,  Roger Sherwood

    IPC分类号： C12N15/00 ,  A61K31/265 ,  A61K31/27 ,  A61K31/40 ,  A61K35/76 ,  A61K38/00 ,  A61K38/44 ,  A61K45/00 ,  A61K48/00 ,  A61P35/00 ,  A61P43/00 ,  C07H21/04 ,  C07K14/195 ,  C12N9/02 ,  C12N15/53 ,  C12N5/00

    CPC分类号： C12N9/0036 ,  A61K38/44 ,  A01K2217/05 ,  A61K48/00

    摘要： A system is disclosed which comprises: (i) a viral vector comprising a nucleotide sequence encoding a nitroreductase, which nitroreductase is capable of converting a prodrug into a cytotoxic drug; and (ii) a prodrug capable of being converted into a cytotoxic drug by the nitroreductase encoded by the vector. The disclosed invention also includes methods for killing cancerous and/or non-cancerous cells using the system described above. Included in the invention are methods for killing cells in vitro by introducing a vector encoding a nitroreductase into the cells, and then by providing a prodrug to the cells growing in vitro. Also included are methods in which cancerous and/or non-cancerous cells are killed in vivo in an animal or human by administering the vector and prodrug directly to cells of the animal or human. The invention further includes methods in which cancerous and/or non-cancerous cells are killed in vivo in an animal or human, by introducing a viral vector encoding a nitroreductase into animal or human cells growing in vitro so that the nitroreductase is produced in the cells, administering the cells to an animal or human subject, and then administering a prodrug to the animal or human, where it is converted into a cytotoxic agent in nitroreductase-containing cells of the animal or human.

    摘要翻译： PCT No.PCT / GB94 / 02423 Sec。 371日期：1996年7月1日 102（e）日期1996年7月1日PCT 1994年11月4日PCT PCT。 WO95 / 12678 PCT出版物 日期1995年5月11日公开了一种系统，其包括：（i）包含编码硝基还原酶的核苷酸序列的病毒载体，所述硝基还原酶能够将前药转化为细胞毒性药物; 和（ii）能够通过载体编码的硝基还原酶转化成细胞毒性药物的前药。 所公开的发明还包括使用上述系统杀死癌和/或非癌细胞的方法。 本发明包括通过将编码硝基还原酶的载体引入细胞，然后通过向体外生长的细胞提供前体来在体外杀死细胞的方法。 还包括通过将该载体和前药直接施用于动物或人的细胞，在动物或人体内将癌和/或非癌细胞体内杀死的方法。 本发明还包括通过将编码硝基还原酶的病毒载体引入体外生长的动物或人类细胞中，使动物或人体内杀死癌细胞和/或非癌细胞的方法，使得在细胞中产生硝基还原酶 给动物或人类受试者施用细胞，然后向动物或人施用前体药物，在动物或人类的硝酸还原酶细胞中转化成细胞毒性剂。

    Liquidambar derived cleaners
    9.
    发明授权
    Liquidambar derived cleaners 有权

    公开(公告)号：US10271556B2

    公开(公告)日：2019-04-30

    申请号：US14283861

    申请日：2014-05-21

    申请人： G. Richard Knox, Jr.

    发明人： G. Richard Knox, Jr.

    IPC分类号： A61K36/00 ,  A01N65/08 ,  A61K36/185 ,  A61K8/97 ,  C11D1/00 ,  A61Q11/00 ,  A61Q5/02 ,  A61Q19/10 ,  A61L9/14 ,  C11D3/382 ,  C11D7/44

    摘要： The present invention is a surfactant(s) for use as a cleaner and freshener as well as methods for the production/use of such surfactants/cleaners/fresheners. The surfactant is produced using and relying upon properties of the Liquidambar tree, particularly the Liquidambar leaf, by creating a liquid solution useful for cleaning and freshening purposes by soaking or steeping the leaves of Liquidambar in a solvent, preferably water. The solutions formed have been found to be effective for general cleaning and freshening purposes including, but not limited to, all known household cleaning/freshening purposes as well as for personal bodily cleaning/freshening purposes including, but not limited to, body washing, hair washing, tooth brushing, mouth washing, and the like. It is non-allergenic, non-toxic, and will cause no adverse environmental effects.